DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment elg1 and rfc1

DIOPT Version :9

Sequence 1:	NP_996103.1	Gene:	elg1 / 39770	FlyBaseID:	FBgn0036574	Length:	1162	Species:	Drosophila melanogaster
Sequence 2:	NP_001082960.2	Gene:	rfc1 / 100037336	ZFINID:	ZDB-GENE-070410-99	Length:	1147	Species:	Danio rerio

Alignment Length:	1235	Identity:	262/1235 - (21%)
Similarity:	438/1235 - (35%)	Gaps:	323/1235 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 TTASPPGTPSKNAATD--------PVEPTSPFVLRAP-----PSAKSK--LILQNMEEVLNSVKQ 66
            |:..|....:.|.:|.        ..:.:.|.| ::|     ||.|.|  :|:.:..|....||.
Zfish     8 TSTKPVAQKASNGSTSTSTDEEQKKKQKSRPKV-KSPKSDEKPSGKRKKRVIVDSDSEEEKKVKT 71

  Fly    67 KHREKHKRKREEKRRAALM---EDQKSTTEEVKANAKEKPQPLREKSSQENGLKNGRRRSSPLK- 127
            |...|......||:.....   .|...|.|.:|     ||:|      :|||...|::.|...|
Zfish    72 KKSTKETSIPTEKKHPVTYVSDSDSDGTFETLK-----KPKP------KENGTAKGKKESDSGKA 125

  Fly   128 -------SSTPVADNQSIMKHFAKAGKPENVGVSP-VSTAKPKP-TTNVFEFMMNARNRSLGVNE 183
                   |.:|| .:.|.:|...|:.:|.   ||| |:...||. .|:|..|.
Zfish   126 KQVKVSSSKSPV-KSPSTVKGGVKSSQPT---VSPKVAPTPPKQMPTSVMAFF------------ 174

  Fly   184 GGAESPADQEIGSEAATPTTKRKLLLQEWNERKGGAKRRLADEARGEFIELQMEQRAKRLRKMLT 248
             |:.|....| ....|:.:||||..|:        ....|:|||..:  ||||:: .|.|.|.:.
Zfish   175 -GSSSVQRSE-KKMVASSSTKRKAPLE--------TDESLSDEAIAK--ELQMDE-DKELEKQIH 226

  Fly   249 KTD--AKEVTAPSSAPTDPTVKRLRGRPRSRRISSMD---AQNQIVES--KPPVVKAKDQDPGTE 306
            ..:  |:.:.....||.          |:..|:.|:.   :.:|.:.|  ||    .||..|.|.
Zfish   227 DDEEFARTLAMLDDAPL----------PKKARVDSISPSKSSSQAIASDIKP----KKDLSPKTS 277

  Fly   307 EL-----LSKLSSPTKKRDSLLGYFPKVESPKELAEKVI-IAIETPPME-TPKRRTLRRKSQQET 364
            .:     |:::....::||.        :..|:..||.| |:.:..|:. |...|....|:...:
Zfish   278 PVKTSSKLAQMKRRQEERDE--------QGKKDKGEKQIKISPKKEPISPTSSERAATPKTASAS 334

  Fly   365 PIVAESTPSSRPRRSCVGKARYDYDLETSPGKQQKAKP-----QKADESVEIIDLDNSNPAATPK 424
            ..:|:|...|.|:...|..       :|||.|.:...|     ::|:.|.....|:...|.|...
Zfish   335 AGMAKSRNLSTPKSESVPS-------KTSPTKPENTSPDDLEKKRANSSAYRSYLNREGPRALGS 392

  Fly   425 KLAPLFVRQLPKPSPDPSVLKARQAFLQSGVPDKIRQEQIRQKNFDQMY----------EDSYEV 479
            |         ..|..:.:.|:. ..|:.:||.:.:.:::  .|:..:.|          :.:|.|
Zfish   393 K---------DIPQGEENCLEG-CVFVLTGVLESMERDE--AKSLIERYGGKVTGNVSRKTTYLV 445

  Fly   480 FPRLAHIG----CESFGSKNGPLDIPFALRAEEEYSEVTKALPANKRRAKASSITSCLPADFTSS 540
            ..|.:.:.    .||||:|         :..|:|..::.:..|..|.:.:.::     .|:..||
Zfish   446 LGRDSGVSKTEKAESFGTK---------IINEDELLDLIRTKPGKKSKYEIAA-----EAENKSS 496

  Fly   541 KTLNKFNYATLPQLENKRGFVKLWKNDFDRFPTFKCYNQMREKYRHFSAIDSAQDTQQMGESLVV 605
            ||          :..:.||  |:..:.....|.....|: |......|...||..:...|.|...
Zfish   497 KT----------RTPDSRG--KVASSAKKATPQGPSPNK-RSSSGGKSKPGSASKSGARGASCSE 548

  Fly   606 TRRTRRSMEQNMAQNEEEAKP-PPSAPNGE---LLFTEKYKPLLFEQVLVNLTPVQ-------EL 659
            .::: .|.:|.     :.|.| ..|||..:   ||:.:||:|    :.|.||...|       :|
Zfish   549 VKKS-LSFDQT-----KTASPVSHSAPENDGSSLLWVDKYRP----RSLKNLIGQQGDQSCANKL 603

  Fly   660 REFLSSW----SGNGGSNRNSQGMDDTFDMSNDSASMGSSSNTMVLVGPSSSGKTNAVFTLANDM 720
            ..:|.||    |||..:.....|   .|...:|    ||.....:|.||...|||.....:..::
Zfish   604 LRWLQSWHKHHSGNAKAPAPKFG---KFGSKDD----GSGFKAALLSGPPGVGKTTTAALVCEEL 661

  Fly   721 NFNVLEINAGMKRTGKKLIQELQEATQSHQIRKDGKAGGGSSQQLLQKLQKSGLKAKAAAVEPPS 785
            .::.:|:||...|:...|.:.:.|:..:..|:   ....|:||.:..
Zfish   662 GYSYVEMNASCTRSKNSLKEVIAESLNNTSIK---NFYTGASQTVSS------------------ 705

  Fly   786 EVRKSLILIEDADILFDNLDAGFTDAIYTLAASSKRPVIVVATDPNCAHLQRLMQQNI-IHFQAP 849
               |.::::::.|.:..|.|.|....:..|...||.|:|.:..|.|...::.|..... :.||.|
Zfish   706 ---KHVLIMDEVDGMAGNEDRGGIQEMIGLIKQSKIPIICMCNDRNHQKIRSLANYCYDLRFQRP 767

  Fly   850 NALNISRFLAVLSLMENCPIELDELISVYLYNQQNLRKTLMELQFYIQSGGDSTRDRTGGGIKSP 914
            ....|...:..::..|...|....|..|.|.:.|::|:.|..|..:.......|.|:......:.
Zfish   768 RVEQIKGAMMSIAFKEGLKIPPPALNEVILASNQDIRQVLHNLSMWSAKDKVMTYDQAKADANNA 832

  Fly   915 TK-----------------TSNSRLATVDGSRIHQRFFEFFTSPQNVQYRIPFPVDFSLLRLNLP 962
            .|                 ...:.::.:|.|.:   ||.                |:|     |.
Zfish   833 KKDMKLGPFDVCRKVFALGEETAHMSLIDKSDL---FFH----------------DYS-----LA 873

  Fly   963 DLMASSAMLKEQQAAGGGSRTAAKRKSRSPKKAWLSSATGQKSDGHSSSLATLASFYDNISVASL 1027
            .|......|..:.||.||:.                          .|.|..|:...|:|....|
Zfish   874 PLFVQENYLHVRPAAAGGNL--------------------------KSHLVLLSKTADSICDGDL 912

  Fly  1028 MDSDCSDRLQWHLSEEIGHLLVEQALQTGLATKE------CPYNLFDKPVQRFS----------- 1075
            :|.....:..|       .||..||:...:...|      ..:..|...:.:||
Zfish   913 VDRQIRSKQTW-------SLLPTQAIYASVLPGELMRGYMSQFPNFPSWLGKFSSSGKHSRIIQE 970

  Fly  1076 ICQHLGNGVLRSDSAKSLDFEPALRSICRSEKERAGLERKSSRF-----YHYLRNHTVNVTSFTT 1135
            :..|:....|.|..|.:||:.|.|||......:..|.|..:...     |..::....|:...:|
Zfish   971 LASHMSLKTLSSKEAVNLDYLPYLRSAVLKPLQSLGSEGANQSVKLMDDYDIIKEDVDNMMEIST 1035

Fly 1136 1135
Zfish 1036 1035

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
elg1	NP_996103.1	Selenoprotein_S	<57..129	CDD:284376	20/82 (24%)
elg1	NP_996103.1	P-loop_NTPase	699..828	CDD:304359	26/128 (20%)
rfc1	NP_001082960.2	BRCT	405..476	CDD:237994	15/82 (18%)
		PRK04195	576..1131	CDD:235250	110/552 (20%)
		AAA	641..768	CDD:278434	31/150 (21%)
		RFC1	907..1060	CDD:285691	27/136 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5275
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900