DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment LHX1 and toy

DIOPT Version :9

Sequence 1:	NP_005559.2	Gene:	LHX1 / 3975	HGNCID:	6593	Length:	406	Species:	Homo sapiens
Sequence 2:	NP_001368990.1	Gene:	toy / 43833	FlyBaseID:	FBgn0019650	Length:	655	Species:	Drosophila melanogaster

Alignment Length:	296	Identity:	79/296 - (26%)
Similarity:	122/296 - (41%)	Gaps:	53/296 - (17%)

- Green bases have known domain annotations that are detailed below.

Human   118 YLSNSSVAKENSLHSATTGSDP-SLSPD-------------SQDPSQDDAKDSESANVSDKEAGS 168
            |.||::.|......:|:..:.| :||..             |.:.|..::.||.|...|:..:..
  Fly   187 YPSNTTTAHLTLPPAASVVTSPANLSGQADRDDVQKRELQFSVEVSHTNSHDSTSDGNSEHNSSG 251

Human   169 NENDDQNLGAKRR--GPRTTIKAKQLETLKAAFAATPKPTRHIREQLAQETGLNMRVIQVWFQNR 231
            :|:....|..||:  ..||:...:|:::|:..|..|..|....||:||.:.||....|||||.||
  Fly   252 DEDSQMRLRLKRKLQRNRTSFSNEQIDSLEKEFERTHYPDVFARERLADKIGLPEARIQVWFSNR 316

Human   232 RSKERRMKQLSALGARRHAFFRSPRRMRPLVD---RLEPGELIPNGPFSFYGDYQSEYYGPGGNY 293
            |:|.||.:::           |:.||....||   |..... .|:|..:......|....||...
  Fly   317 RAKWRREEKM-----------RTQRRSADTVDGSGRTSTAN-NPSGTTASSSVATSNNSTPGIVN 369

Human   294 DFFPQGPPSSQAQTPVDLPFVPSSGPSGTPLGGLEHPLPGHHPSSEAQRFTDILAHPPGDSPSPE 358
            ........:|.|.....|| ..|:||  |.|||            ||.     ..|...:||..:
  Fly   370 SAINVAERTSSALVSNSLP-EASNGP--TVLGG------------EAN-----TTHTSSESPPLQ 414

Human   359 PSLPG-PLHSMSAEVFGPSP-PFSSLSVNGGASYGN 392
            |:.|. ||:|....::...| |.::::.|..:|.|:
  Fly   415 PAAPRLPLNSGFNTMYSSIPQPIATMAENYNSSLGS 450

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LHX1	NP_005559.2	LIM1_Lhx1_Lhx5	4..55	CDD:188753
		LIM2_Lhx1_Lhx5	63..118	CDD:188761	79/296 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	128..187		16/74 (22%)
		Homeobox	183..236	CDD:278475	22/52 (42%)
		An_peroxidase_like	<291..>382	CDD:265428	23/92 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	293..374		21/81 (26%)
toy	NP_001368990.1	PAX	29..153	CDD:128645
		COG5576	<253..368	CDD:227863	39/126 (31%)
		Homeobox	269..322	CDD:395001	22/52 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910