DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LHX1 and zfh1

DIOPT Version :9

Sequence 1:	NP_005559.2	Gene:	LHX1 / 3975	HGNCID:	6593	Length:	406	Species:	Homo sapiens
Sequence 2:	NP_733401.3	Gene:	zfh1 / 43650	FlyBaseID:	FBgn0004606	Length:	1206	Species:	Drosophila melanogaster

Alignment Length:	333	Identity:	81/333 - (24%)
Similarity:	112/333 - (33%)	Gaps:	127/333 - (38%)

- Green bases have known domain annotations that are detailed below.

Human    83 VFHLNCFTCMMCNKQLSTGEELYIIDENKFVC---KEDYLSNSSVAKENSLHSATTGSDPSLSPD 144
            |.|.....|..|:||.:...||  :...|.:|   ||:...:....:..|.         :|:..
  Fly   622 VEHAADLRCSRCSKQFNHPTEL--VQHEKVLCGLIKEELEQHFQQQQATSF---------ALASA 675

Human   145 SQDPSQDDAKDSESANVSDKEAGSNENDDQNLGAKRRGPRTTIKAKQLETLKAAFAATPKPTRHI 209
            |::..:|:..|.|            |...|..|.::...||.|..:|.:.||..::...:|:|..
  Fly   676 SEEDEEDEEMDVE------------EEPRQESGERKVRVRTAINEEQQQQLKQHYSLNARPSRDE 728

Human   210 REQLAQETGLNMRVIQVWFQNRRSKERRMKQL---SALGARRHAFFRSPRRMRPLVDRLEPGELI 271
            ...:|....|:.||:||||||.||:||:|:..   .|.||.
  Fly   729 FRMIAARLQLDPRVVQVWFQNNRSRERKMQSFQNNQAAGAA------------------------ 769

Human   272 PNGPFSFYGDYQSEYYGPGGNYDFFPQGPPSSQA-----QTPVDL-----PFVP---SSGPSGTP 323
                                     |..|..|||     ..|:||     |..|   ||.|...|
  Fly   770 -------------------------PPMPIDSQASLTREDQPLDLSVKRDPLTPKSESSPPYIAP 809

Human   324 LGGLEHPLPGHHPSSEA---------QRF-TDILAHPPGDSPSPEPSLPGPLHSMSAEVFG---- 374
                        ||.||         ::| |.....|...|||          |.:|..||
  Fly   810 ------------PSGEALNPEAINLSRKFSTSASMSPASISPS----------SAAALYFGAAPP 852

Human   375 PSPPFSSL 382
            ||||.|.|
  Fly   853 PSPPNSQL 860

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LHX1	NP_005559.2	LIM1_Lhx1_Lhx5	4..55	CDD:188753
		LIM2_Lhx1_Lhx5	63..118	CDD:188761	12/37 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	128..187		11/58 (19%)
		Homeobox	183..236	CDD:278475	20/52 (38%)
		An_peroxidase_like	<291..>382	CDD:265428	33/117 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	293..374		26/103 (25%)
zfh1	NP_733401.3	C2H2 Zn finger	291..311	CDD:275368
		C2H2 Zn finger	326..346	CDD:275368
		zf-C2H2	355..377	CDD:278523
		C2H2 Zn finger	357..377	CDD:275368
		zf-H2C2_2	369..391	CDD:290200
		Homeobox	703..755	CDD:278475	20/51 (39%)
		C2H2 Zn finger	969..989	CDD:275368
		zf-H2C2_2	981..1006	CDD:290200
		COG5048	992..>1045	CDD:227381
		C2H2 Zn finger	997..1017	CDD:275368
		zf-H2C2_2	1009..1034	CDD:290200
		C2H2 Zn finger	1025..1042	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910