DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment LHX1 and tin

DIOPT Version :9

Sequence 1:	NP_005559.2	Gene:	LHX1 / 3975	HGNCID:	6593	Length:	406	Species:	Homo sapiens
Sequence 2:	NP_524433.1	Gene:	tin / 42536	FlyBaseID:	FBgn0004110	Length:	416	Species:	Drosophila melanogaster

Alignment Length:	220	Identity:	54/220 - (24%)
Similarity:	82/220 - (37%)	Gaps:	50/220 - (22%)

- Green bases have known domain annotations that are detailed below.

Human   112 FVCKEDYLSNSSVAKENSLHSAT--------------TGSDPSLSPDSQDPSQDDAKDSESANVS 162
            :|.....|..:|.|:.:||.:.|              |.|:.| |..|...|.:.||..:::.|:
  Fly   209 YVTPSPTLDLNSSAEVDSLQAPTQKLCVNPLSQRLMETASNSS-SLRSIYGSDEGAKKKDNSQVT 272

Human   163 DKEA-------GSNENDDQNLGA----KRRGPRTTIKAKQLETLKAAFAATPKPTRHIREQLAQE 216
            ...:       ..|.|...|.|:    .:|.||......|:..|:..|......|...||.:||:
  Fly   273 SSRSELRKNSISGNSNPGSNSGSTKPRMKRKPRVLFSQAQVLELECRFRLKKYLTGAEREIIAQK 337

Human   217 TGLNMRVIQVWFQNRRSKERRMKQLSALGARRHAFFRSPRRMRPLVDRLEPGELIPNGPFSFYGD 281
            ..|:...:::||||||.|.:| ..:...|..:|...:|    .||.   .|..|.|
  Fly   338 LNLSATQVKIWFQNRRYKSKR-GDIDCEGIAKHLKLKS----EPLD---SPTSLPP--------- 385

Human   282 YQSEYYGPGGNYDFFPQGPPSSQAQ 306
                   |..|:..:|.....||.|
  Fly   386 -------PIPNHVMWPPTMQQSQQQ 403

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LHX1	NP_005559.2	LIM1_Lhx1_Lhx5	4..55	CDD:188753
		LIM2_Lhx1_Lhx5	63..118	CDD:188761	1/5 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	128..187		19/83 (23%)
		Homeobox	183..236	CDD:278475	18/52 (35%)
		An_peroxidase_like	<291..>382	CDD:265428	5/16 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	293..374		4/14 (29%)
tin	NP_524433.1	HOX	301..357	CDD:197696	19/55 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910