DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment LHX1 and Mlp84B

DIOPT Version :9

Sequence 1:	NP_005559.2	Gene:	LHX1 / 3975	HGNCID:	6593	Length:	406	Species:	Homo sapiens
Sequence 2:	NP_001303418.1	Gene:	Mlp84B / 40849	FlyBaseID:	FBgn0014863	Length:	495	Species:	Drosophila melanogaster

Alignment Length:	381	Identity:	71/381 - (18%)
Similarity:	107/381 - (28%)	Gaps:	180/381 - (47%)

- Green bases have known domain annotations that are detailed below.

Human    22 RAWHVKCVQCCECKCNLTE--KCFSREGKLYCKNDFFRCFGTKCAGCAQG--------------- 69
            |:||.:|.:|..||..|..  .|.:.:..:|||..:.:.||.|..|..||
  Fly   138 RSWHKECFKCGTCKKGLDSILCCEAPDKNIYCKGCYAKKFGPKGYGYGQGGGALQSDCYAHDDGA 202

Human    70 -------------ISPSD-------LVRRARSKV-----FHLNCFTCMMCNKQLST--------- 100
                         ..|.:       :|..|..|:     :|..||.|..|:|.|.:
  Fly   203 PQIRAAIDVDKIQARPGEGCPRCGGVVYAAEQKLSKGREWHKKCFNCKDCHKTLDSINASDGPDR 267

Human   101 ------------GEELYIIDENKFVCKEDYLSNSSVAKENSLHSATTGSDPSLSPDSQDPSQDDA 153
                        |...|     .|.|...:|....:.::.     .:.:.|..:||:   :...|
  Fly   268 DVYCRTCYGKKWGPHGY-----GFACGSGFLQTDGLTEDQ-----ISANRPFYNPDT---TSIKA 319

Human   154 KDSESANVSDKEAGSNENDDQNLGAKRRGPRTTIKAKQLETLKAAFAATPKPTRHIREQLAQETG 218
            :|.|                   |..|.|             .|.|||        .:||::.
  Fly   320 RDGE-------------------GCPRCG-------------GAVFAA--------EQQLSKG-- 342

Human   219 LNMRVIQVWFQ---NRRSKERRMKQLSALGARRHAFFRSPRRMRPLVDRLEPGELIPNGPF---S 277
                  :||.:   |.....|.:..:.|...                         |:|..   :
  Fly   343 ------KVWHKKCYNCADCHRPLDSVLACDG-------------------------PDGDIHCRA 376

Human   278 FYGDYQSEYYGPGG-NYDFFPQGPPSSQAQTPVDLPFVPSSG------PSGTPLGG 326
            .||    :.:||.| .|...|              ..|.:||      |.|.||.|
  Fly   377 CYG----KLFGPKGFGYGHAP--------------TLVSTSGESTIQFPDGRPLAG 414

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LHX1	NP_005559.2	LIM1_Lhx1_Lhx5	4..55	CDD:188753	12/34 (35%)
		LIM2_Lhx1_Lhx5	63..118	CDD:188761	18/115 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	128..187		9/58 (16%)
		Homeobox	183..236	CDD:278475	9/55 (16%)
		An_peroxidase_like	<291..>382	CDD:265428	11/43 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	293..374		10/40 (25%)
Mlp84B	NP_001303418.1	LIM1_MLP84B_like	11..64	CDD:188788
		LIM_CRP_like	120..173	CDD:188712	12/34 (35%)
		LIM_CRP_like	222..275	CDD:188712	10/52 (19%)
		LIM_CRP_like	325..378	CDD:188712	15/106 (14%)
		LIM_CRP_like	421..474	CDD:188712
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910