DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment LHX1 and vvl

DIOPT Version :9

Sequence 1:	NP_005559.2	Gene:	LHX1 / 3975	HGNCID:	6593	Length:	406	Species:	Homo sapiens
Sequence 2:	NP_001303384.1	Gene:	vvl / 38752	FlyBaseID:	FBgn0086680	Length:	742	Species:	Drosophila melanogaster

Alignment Length:	299	Identity:	69/299 - (23%)
Similarity:	103/299 - (34%)	Gaps:	67/299 - (22%)

- Green bases have known domain annotations that are detailed below.

Human   111 KFVCKEDYLSNSSVAKENSLHSATTGSDPSLSPDSQDPSQDDAKDSESANVSDKEAGSNENDDQN 175
            |.:||...|....:.:.:|    ||||..|:                     ||.|..
  Fly   269 KNMCKLKPLLQKWLEEADS----TTGSPTSI---------------------DKIAAQ------- 301

Human   176 LGAKRRGPRTTIKAKQLETLKAAFAATPKPTRHIREQLAQETGLNMRVIQVWFQNRRSKERRMKQ 240
             |.||: .||:|:......|:..|...|||:......||....|...|::|||.|||.||:||..
  Fly   302 -GRKRK-KRTSIEVSVKGALEQHFHKQPKPSAQEITSLADSLQLEKEVVRVWFCNRRQKEKRMTP 364

Human   241 LSALGARRHAFFRSPRRMRPLVDRLEPGELIPNGPFSFYGDYQSEYYGPGGNYD-------FFPQ 298
            .:.||.             .::|.:.||.:...|    |..:...:..|.|.:.       ..||
  Fly   365 PNTLGG-------------DMMDGMPPGHMHHGG----YHPHHDMHGSPMGTHSHSHSPPMLSPQ 412

Human   299 GPPSS-------QAQTPVDLPFVPSSGPSGTP--LGGLEHPLPGHHPSSEAQRFTDILAHPPGDS 354
            ...||       .|. ..::....|:..:.||  |..|...........:.|............:
  Fly   413 NMQSSAVAAHQLAAHXQSEIQESNSAAAASTPASLNSLSQQQQQQQQQQQQQHQQQQQHQQQQHT 477

Human   355 PSPEPSLPGPLHSMSAEVFGPSPPFSSLSVNGGASYGNH 393
            |:...|..|...:|:::|..|..|..|.|....|:..|:
  Fly   478 PNTPSSSAGSSATMTSQVMSPQSPLGSSSAGNQANNNNN 516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LHX1	NP_005559.2	LIM1_Lhx1_Lhx5	4..55	CDD:188753
		LIM2_Lhx1_Lhx5	63..118	CDD:188761	3/6 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	128..187		14/58 (24%)
		Homeobox	183..236	CDD:278475	19/52 (37%)
		An_peroxidase_like	<291..>382	CDD:265428	19/106 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	293..374		16/96 (17%)
vvl	NP_001303384.1	POU	212..286	CDD:197673	4/16 (25%)
vvl	NP_001303384.1	Homeobox	307..360	CDD:278475	19/52 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910