DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment LHX1 and inv

DIOPT Version :9

Sequence 1:	NP_005559.2	Gene:	LHX1 / 3975	HGNCID:	6593	Length:	406	Species:	Homo sapiens
Sequence 2:	NP_523699.3	Gene:	inv / 36239	FlyBaseID:	FBgn0001269	Length:	576	Species:	Drosophila melanogaster

Alignment Length:	189	Identity:	42/189 - (22%)
Similarity:	68/189 - (35%)	Gaps:	51/189 - (26%)

- Green bases have known domain annotations that are detailed below.

Human   113 VCKEDYLSNSSVAKENSLHSA-----------------TTGSDPSLSPDSQDP------------ 148
            :|.....|||:....::.:::                 .||:......||..|
  Fly   361 ICSNSNDSNSTATSSSTTNTSGAPVDLVKSPPPAAGAGATGASGKSGEDSGTPIVWPAWVYCTRY 425

Human   149 -----------SQDDAKDSESANVSDKEAGSNENDDQNLGA---KRRGPRTTIKAKQLETLKAAF 199
                       ::...|.:.|::.:....|..|..:...|.   :.:.|||.....||..||..|
  Fly   426 SDRPSSGRSPRARKPKKPATSSSAAGGGGGGVEKGEAADGGGVPEDKRPRTAFSGTQLARLKHEF 490

Human   200 AATPKPTRHIREQLAQETGLNMRVIQVWFQNRRSKERRMK--------QLSALGARRHA 250
            ......|...|:||:.|.|||...|::||||:|:|.::..        ||.|.|...|:
  Fly   491 NENRYLTEKRRQQLSGELGLNEAQIKIWFQNKRAKLKKSSGTKNPLALQLMAQGLYNHS 549

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LHX1	NP_005559.2	LIM1_Lhx1_Lhx5	4..55	CDD:188753
		LIM2_Lhx1_Lhx5	63..118	CDD:188761	1/4 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	128..187		13/101 (13%)
		Homeobox	183..236	CDD:278475	23/52 (44%)
		An_peroxidase_like	<291..>382	CDD:265428
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	293..374
inv	NP_523699.3	Homeobox	474..527	CDD:278475	23/52 (44%)
inv	NP_523699.3	Engrail_1_C_sig	529..554	CDD:287495	5/21 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910