DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment LHX1 and ap

DIOPT Version :9

Sequence 1:	NP_005559.2	Gene:	LHX1 / 3975	HGNCID:	6593	Length:	406	Species:	Homo sapiens
Sequence 2:	NP_724428.1	Gene:	ap / 35509	FlyBaseID:	FBgn0267978	Length:	469	Species:	Drosophila melanogaster

Alignment Length:	288	Identity:	103/288 - (35%)
Similarity:	148/288 - (51%)	Gaps:	63/288 - (21%)

- Green bases have known domain annotations that are detailed below.

Human     4 CAGCKRPILDRFLLNVLDRAWHVKCVQCCECKCNLTEK--CFSREGKLYCKNDFFRCFGT-KCAG 65
            |:||.|.|.|||.|:.:::.||..|:||..|:..|..:  |:||:|.:|||||::..||| :|:.
  Fly   148 CSGCGRQIQDRFYLSAVEKRWHASCLQCYACRQPLERESSCYSRDGNIYCKNDYYSFFGTRRCSR 212

Human    66 CAQGISPSDLVRRARSKVFHLNCFTCMMCNKQLSTGEELYIIDENKFVCKEDYLSNSSVAKENSL 130
            |...||.::||.|||:.|||:|||.|.:|:..|:.|::..|||. ...|:..|    |:|:|...
  Fly   213 CLASISSNELVMRARNLVFHVNCFCCTVCHTPLTKGDQYGIIDA-LIYCRTHY----SIAREGDT 272

Human   131 ----------HSATTGS--DPSLSPDSQDPSQD------------------------------DA 153
                      :||..||  :.|.||.| |||:.                              ..
  Fly   273 ASSSMSATYPYSAQFGSPHNDSSSPHS-DPSRSIVPTGIFVPASHVINGLPQPARQKGRPRKRKP 336

Human   154 KDSE--SANVS------DKEAGSNENDDQNLGAKRRGPRTTIKAKQLETLKAAFAATPKPTRHIR 210
            ||.|  :||:.      |...||:.:.    .::.:..||:.|..||.|:|:.||....|.....
  Fly   337 KDIEAFTANIDLNTEYVDFGRGSHLSS----SSRTKRMRTSFKHHQLRTMKSYFAINHNPDAKDL 397

Human   211 EQLAQETGLNMRVIQVWFQNRRSKERRM 238
            :||:|:|||..||:||||||.|:|.|||
  Fly   398 KQLSQKTGLPKRVLQVWFQNARAKWRRM 425

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LHX1	NP_005559.2	LIM1_Lhx1_Lhx5	4..55	CDD:188753	24/52 (46%)
		LIM2_Lhx1_Lhx5	63..118	CDD:188761	23/54 (43%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	128..187		21/108 (19%)
		Homeobox	183..236	CDD:278475	26/52 (50%)
		An_peroxidase_like	<291..>382	CDD:265428
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	293..374
ap	NP_724428.1	LIM1_Lhx2_Lhx9	148..201	CDD:188755	24/52 (46%)
		LIM2_Lhx2_Lhx9	206..264	CDD:188763	25/58 (43%)
		Homeobox	371..424	CDD:395001	26/52 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910