DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LHX1 and tup

DIOPT Version :9

Sequence 1:	NP_005559.2	Gene:	LHX1 / 3975	HGNCID:	6593	Length:	406	Species:	Homo sapiens
Sequence 2:	NP_001286068.1	Gene:	tup / 35147	FlyBaseID:	FBgn0003896	Length:	534	Species:	Drosophila melanogaster

Alignment Length:	467	Identity:	144/467 - (30%)
Similarity:	205/467 - (43%)	Gaps:	102/467 - (21%)

- Green bases have known domain annotations that are detailed below.

Human     3 HCAGCKRPILDRFLLNVL-DRAWHVKCVQCCECKCNLTEK--CFSREGKLYCKNDFFRCFGTKCA 64
            ||.||...|.|:::|.|. |..||..|::|.||:..|.|.  ||.|:||.|||.|:.|.|||||.
  Fly    53 HCVGCGGQIHDQYILRVAPDLEWHAACLKCQECRQFLDESCTCFVRDGKTYCKRDYVRLFGTKCD 117

Human    65 GCAQGISPSDLVRRARSKVFHLNCFTCMMCNKQLSTGEELYIIDENKFVCKEDY----------L 119
            .|....|.:|.|.||::|:||:.||.|..|.:||..|:|..:.|.....||||:          |
  Fly   118 KCGNSFSKNDFVMRAKTKIFHIECFRCSACARQLLPGDEFALRDAGALYCKEDHDVLEKSSQSSL 182

Human   120 SNSSVAKENSLHSATTGSDPSLSPDSQDPSQDDAKDSESANVSDKEAGSNENDDQNLGAKR-RGP 183
            ::|||...|:: |::..::.:||.::.        .||..::||  :||.....:::..|| .||
  Fly   183 TSSSVESNNNI-SSSNNNNTNLSNNNH--------SSELGSMSD--SGSESGSHKSIRDKRPSGP 236

Human   184 --------RTTIKAKQLETLKAAFAATPKPTRHIREQLAQETGLNMRVIQVWFQNRRSKERR--- 237
                    ||.:..|||.||:..:.|.|:|...::|||.:.|.|:.|||:|||||:|.|:::
  Fly   237 SDGKPTRVRTVLNEKQLHTLRTCYNANPRPDALMKEQLVEMTSLSPRVIRVWFQNKRCKDKKKTI 301

Human   238 -----MKQ----------------LSALGARRHAFFRSPRRMRPL-VDRLEP-----------GE 269
                 |:|                :.|....||   .||..::.| |...:|           .:
  Fly   302 QMKLQMQQEKEGRKLGYGAMQGIPMIASSPVRH---DSPLNLQGLDVQTYQPPWKALSDFALHAD 363

Human   270 LIPNGPFSFYGDYQSEYYGPGGNYD-----FFPQGPPSSQAQTPVDLPFVPSSG----------- 318
            |..||..:.:.....:.......||     ..|..|.|..||.|......|..|
  Fly   364 LDSNGAINTHTPAFQQLVNQMHGYDLNGMPILPPHPHSHPAQGPPHQHPPPPGGPHNHQNQQPNQ 428

Human   319 -PSGTPL--GGLEHPLPGHHPSSEAQRFTD-ILAHPPGDSPSPEPSLPGPLHSMSAEVFGPSPPF 379
             |.|:.|  |...|    |||.|     || .:.:...|..|.....|....|.||.....|||
  Fly   429 QPGGSSLDSGITSH----HHPDS-----TDSYVTYLESDDKSKLALTPSSSSSASAGTSISSPP- 483

Human   380 SSLSVNGGASYG 391
            |.:...||.:.|
  Fly   484 SGVGAGGGGAVG 495

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LHX1	NP_005559.2	LIM1_Lhx1_Lhx5	4..55	CDD:188753	24/53 (45%)
		LIM2_Lhx1_Lhx5	63..118	CDD:188761	22/54 (41%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	128..187		16/67 (24%)
		Homeobox	183..236	CDD:278475	26/60 (43%)
		An_peroxidase_like	<291..>382	CDD:265428	31/110 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	293..374		27/100 (27%)
tup	NP_001286068.1	LIM1_Isl	54..108	CDD:188752	24/53 (45%)
		LIM2_Isl	116..171	CDD:188760	22/54 (41%)
		HOX	241..297	CDD:197696	25/55 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910