DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment LHX1 and Pph13

DIOPT Version :9

Sequence 1:	NP_005559.2	Gene:	LHX1 / 3975	HGNCID:	6593	Length:	406	Species:	Homo sapiens
Sequence 2:	NP_477330.1	Gene:	Pph13 / 33239	FlyBaseID:	FBgn0023489	Length:	357	Species:	Drosophila melanogaster

Alignment Length:	242	Identity:	60/242 - (24%)
Similarity:	82/242 - (33%)	Gaps:	83/242 - (34%)

- Green bases have known domain annotations that are detailed below.

Human   172 DDQNLGAKRRGPRTTIKAKQLETLKAAFAATPKPTRHIREQLAQETGLNMRVIQVWFQNRRSKER 236
            |...:..|:|..|||....||:.|:.||..|..|....||:||....|....:||||||||:|.|
  Fly     2 DKGTMKRKQRRYRTTFNTLQLQELERAFQRTHYPDVFFREELAVRIDLTEARVQVWFQNRRAKWR 66

Human   237 RMKQLSALGARRHAFFRSPRRMRPLVDRLEPGELIPNGPFSFYGDYQ------------SEYYGP 289
            :.:::..||                                  |||:            |...|.
  Fly    67 KQEKIGGLG----------------------------------GDYKEGALDLDVSYDDSAVLGQ 97

Human   290 -----GGNYDFFPQGPPSSQAQTPVDLPFVPSSG---PS---------------GTPLG--GLEH 329
                 ||.....|..||.|......:|.....:|   ||               |...|  ||..
  Fly    98 LDSALGGGGTLLPDTPPQSSNSLDNELKASYGTGAMSPSRLSPNIFLNLNIDHLGLERGGSGLSM 162

Human   330 PLPGHHPSSEAQRFTDILAHPPGDSPS------PEPSLPGPLHSMSA 370
            ....:.|.::||      .||..||.:      |:.....|:|:.|:
  Fly   163 EWSTYPPQTQAQ------THPQMDSDNQLQQHPPQQHASDPIHAGSS 203

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LHX1	NP_005559.2	LIM1_Lhx1_Lhx5	4..55	CDD:188753
		LIM2_Lhx1_Lhx5	63..118	CDD:188761
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	128..187		5/14 (36%)
		Homeobox	183..236	CDD:278475	24/52 (46%)
		An_peroxidase_like	<291..>382	CDD:265428	24/106 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	293..374		23/104 (22%)
Pph13	NP_477330.1	Homeobox	14..66	CDD:278475	24/51 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910