DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment LHX1 and Zyx

DIOPT Version :9

Sequence 1:	NP_005559.2	Gene:	LHX1 / 3975	HGNCID:	6593	Length:	406	Species:	Homo sapiens
Sequence 2:	NP_652015.1	Gene:	Zyx / 317824	FlyBaseID:	FBgn0011642	Length:	585	Species:	Drosophila melanogaster

Alignment Length:	151	Identity:	44/151 - (29%)
Similarity:	70/151 - (46%)	Gaps:	26/151 - (17%)

- Green bases have known domain annotations that are detailed below.

Human     4 CAGCKRPIL-DRFLLNVLDRAWHVKCVQCCECKCNLTEKCF-SREGKLYCKNDFFRCFGTKCAGC 66
            |..|...:| :......:|:.:|:.|..|.:|:.||..|.| :.:||.||:.|:.:.. .||:.|
  Fly   388 CVKCNSRVLGESSGCTAMDQIYHIFCFTCTDCQINLQGKPFYALDGKPYCEYDYLQTL-EKCSVC 451

Human    67 AQGISPSDLVRRARSKVFHLNCFTCMMCNKQL--------STGEELYIID-ENKF-----VCKED 117
            .:.|  .:.:.||..|.:|..||||::|.|.|        :|.:...|.| ..||     |||:.
  Fly   452 MEPI--LERILRATGKPYHPQCFTCVVCGKSLDGLLFTVDATNQNYCITDFHKKFAPRCCVCKQP 514

Human   118 YLSNSS-------VAKENSLH 131
            .:.:..       ||.:.|.|
  Fly   515 IMPDPGQEETIRVVALDRSFH 535

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LHX1	NP_005559.2	LIM1_Lhx1_Lhx5	4..55	CDD:188753	16/52 (31%)
		LIM2_Lhx1_Lhx5	63..118	CDD:188761	22/68 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	128..187		2/4 (50%)
		Homeobox	183..236	CDD:278475
		An_peroxidase_like	<291..>382	CDD:265428
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	293..374
Zyx	NP_652015.1	LIM1_LPP	388..441	CDD:188737	16/52 (31%)
		LIM2_LPP	448..507	CDD:188740	19/60 (32%)
		LIM3_LPP	508..575	CDD:188821	7/28 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910