Protein Alignment Hip14 and AKR1

DIOPT Version :10

• Sequence 1: NP_001261910.1
• Gene: Hip14 / 39747
• FlyBaseID: FBgn0259824
• Length: 655
• Species: Drosophila melanogaster
• Sequence 2: NP_010550.1
• Gene: AKR1 / 851857
• SGDID: S000002672
• Length: 764
• Species: Saccharomyces cerevisiae
• Alignment Length: 576
• Identity: 165/576 - (28%)
• Similarity: 255/576 - (44%)
• Gaps: 121/576 - (21%)

  Fly    52 ATQYGAIARVRELVESG-WDVNQ--PDSETVTLLHWAAINNRRDIIRYFLEKGATVDAVGGELNA 113
            |.|.|.:|.|:|::... .:||.  ..:|.:|.||||:||||..::.:.:.:||.|:|..|.|:|
Yeast    80 ACQRGDLATVKEMIHGKLLEVNNDGDSTEHITGLHWASINNRLSVVDFLVSQGADVNARAGALHA 144

  Fly   114 TPLHWATRQGHLGAVVLLMAAGADPRIRDAEGCSCIHIAAQFAHTALVAY----FIAKG-VDPDL 173
            ||||||.|.|::..|..|:..||||.:.|.:|.:.:|::...::..||.|    .::|| :|.|.
Yeast   145 TPLHWAARYGYVYIVDFLLKHGADPTMTDDQGFNLLHLSVNSSNIMLVLYVLFNVVSKGLLDIDC 209

  Fly   174 QDRGGMTALMWAAWKVCALDPVRLLLTLGANPAMVDYTHGNTALHWAILARNATAISTLVLKSKA 238
            :|..|.|:|:|||::..:| .|..||..||:..:.| |.|.|.|||..:......:..|:
Yeast   210 RDPKGRTSLLWAAYQGDSL-TVAELLKFGASIKIAD-TEGFTPLHWGTVKGQPHVLKYLI----- 267

  Fly   239 SLDVPNLRGETPLSMLESQTGAIWIGAKVMDRVKEAALTSQQRRSLLSKLR----------HDKR 293
                              |.||.:.  :..|..|:....:|:..::.| ||          |...
Yeast   268 ------------------QDGADFF--QKTDTGKDCFAIAQEMNTVYS-LREALTHSGFDYHGYP 311

  Fly   294 LRWW------SMVACPFTAFYLAGIVFT----VNTLY-IIKFFLL------GCLYSIFHTIGKAL 341
            ::.|      :.:....|.|...||.|.    :|.|: ||..|||      |....:..:.|:
Yeast   312 IKKWFKKSQHAKLVTFITPFLFLGIAFALFSHINPLFVIIVLFLLAIATNKGLNKFVLPSYGR-- 374

  Fly   342 FDEHLMALL--PL--SVYLATKAWFYVTWLM------YIDDAVS------FTATVCFLISSLLLW 390
            ...|.:.||  ||  .|:..|..|..:.|..      :.|:..:      ...:|.:|...|::.
Yeast   375 MGVHNVTLLRSPLLSGVFFGTLLWVTIVWFFKVMPRTFSDEQYTNILMLVILVSVFYLFGQLVIM 439

  Fly   391 VCFLKSWKGDPGII--RPTREQRFKTIIELSERGGIGFEPASFCSGCLVRRPIRSKHCSVCDRCV 453
                     |||.:  ....|...:||..|.|.|  .|:..:||....:|:|:|||...:.:..|
Yeast   440 ---------DPGCLPEETDHENVRQTISNLLEIG--KFDTKNFCIETWIRKPLRSKFSPLNNAVV 493

  Fly   454 ARFDHHCPWVGNCIGLKNHSYFMGFLWMLLIMCAWMLYGGSKYYVNQCNVRFDDFLGA----MRA 514
            |||||:|||:.|.:|||||..|:.|:        .::..|...::..|...||:...|    .:.
Yeast   494 ARFDHYCPWIFNDVGLKNHKAFIFFI--------TLMESGIFTFLALCLEYFDELEDAHEDTSQK 550

  Fly   515 IGNC--------------DAWVGWVMGNALLHMSWVILLTICQTYQVICLGMTTNE 556
            .|.|              |.:|..::..|||...||..|...|.:| ||.|||..|
Yeast   551 NGKCFILGASDLCSGLIYDRFVFLILLWALLQSIWVASLIFVQAFQ-ICKGMTNTE 605

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hip14	NP_001261910.1	ANKYR	<52..246	CDD:440430	70/201 (35%)
		ANK repeat	77..108	CDD:293786	14/30 (47%)
		ANK repeat	110..142	CDD:293786	16/31 (52%)
		ANK repeat	144..175	CDD:293786	9/35 (26%)
		ANK repeat	177..209	CDD:293786	12/31 (39%)
		ANK repeat	212..244	CDD:293786	6/31 (19%)
		DHHC	426..559	CDD:396215	48/149 (32%)
AKR1	NP_010550.1	ANKYR	31..300	CDD:440430	79/247 (32%)
		ANK repeat	75..101	CDD:293786	6/20 (30%)
		ANK repeat	103..140	CDD:293786	14/36 (39%)
		ANK repeat	142..173	CDD:293786	16/30 (53%)
		ANK repeat	213..244	CDD:293786	12/31 (39%)
		ANK repeat	246..271	CDD:293786	7/47 (15%)
		COG5273	363..725	CDD:227598	72/265 (27%)