Protein Alignment Hip14 and zdhhc13

DIOPT Version :10

• Sequence 1: NP_001261910.1
• Gene: Hip14 / 39747
• FlyBaseID: FBgn0259824
• Length: 655
• Species: Drosophila melanogaster
• Sequence 2: NP_001008650.2
• Gene: zdhhc13 / 494107
• ZFINID: ZDB-GENE-041212-79
• Length: 645
• Species: Danio rerio
• Alignment Length: 611
• Identity: 216/611 - (35%)
• Similarity: 334/611 - (54%)
• Gaps: 53/611 - (8%)

  Fly    12 GSCVPGTGQQPDNERQSALIAQQPPTAPVEPDYSGFDIVKATQYGAIARVRELVESGWDVNQPDS 76
            |..|||. ..|         .|||..:....|.|.:||:||||:||:.|.:||||:|:||.|||.
Zfish    49 GQLVPGP-MDP---------TQQPRKSSHPEDSSSWDIIKATQFGALERCKELVEAGYDVRQPDK 103

  Fly    77 ETVTLLHWAAINNRRDIIRYFLEKGATVDAVGGELNATPLHWATRQGHLGAVVLLMAAGADPRIR 141
            |.||||||||||||.||::|::.|||.:|.:||:||:||||||.|||||..|:.||..||||.:.
Zfish   104 ENVTLLHWAAINNRADIVKYYISKGAVIDQLGGDLNSTPLHWAIRQGHLSMVIQLMRYGADPSLA 168

  Fly   142 DAEGCSCIHIAAQFAHTALVAYFIAKGVDPDLQDRGGMTALMWAAWKVCALDPVRLLLTLGANPA 206
            |.||...:|:|..|.:..:.||.:|||.:.||.|..|.|.||.||.|:...:|...|:...|:..
Zfish   169 DGEGYRGLHLAVLFQNMPIAAYLMAKGQEVDLPDLNGQTPLMLAAQKIIGPEPTNFLIKCNASVN 233

  Fly   207 MVDYTHGNTALHWAILARNATAISTLVLKSKASLDVPNLRGETPLSMLESQTGAIWI---GAKVM 268
            .||..:.|:.||.|:||.|..::. ::|::.||:|:.|..|.|.:.:.:.....:.|   .....
Zfish   234 AVDKVNRNSPLHCAVLAGNVDSVH-ILLEAGASVDMQNDNGHTAIDLAQQVHSPLLIHMLSVVKT 297

  Fly   269 DRVK--EAALTSQQRRSLLSKLRHDKRLRWWSMVACPFTAFYLA-----GIVFTVNT-LYIIKFF 325
            :|:|  .|.|      .||::.:           .|..:.|.:.     |.:..:.| .:::|..
Zfish   298 ERIKANSACL------KLLNRYK-----------VCLQSVFSVVVVGAFGAILDMRTESWLLKGI 345

  Fly   326 LLGCLYSIFHTIGKALFDEHLMALLPLSVYLATKAWFYVTW-LMYIDDAVSFTATVCFLISSLLL 389
            ||.|:.::.:...:.|....:.:|:|.:..:|:..|..||| |.::.|..|....:.|.::...:
Zfish   346 LLACIMAVINLASRQLATVAVRSLIPSTGLIASVFWMVVTWVLWFLPDEPSAAVQMLFTVNITAV 410

  Fly   390 WVCFLKSWKGDPGIIRPTREQRFKTIIELSERGGIGFEPASFCSGCLVRRPIRSKHCSVCDRCVA 454
            ...:::|.:.|||.::.|.|::.|.|:.|:|.|.:  :|..||:.|::|:|:|:.||..|:.|||
Zfish   411 LYYYIRSCRTDPGHVKATEEEKKKNIVVLAEAGCL--DPRIFCTSCMMRKPMRANHCFSCNACVA 473

  Fly   455 RFDHHCPWVGNCIGLKNHSYFMGFLWMLLIMCAWMLYGGSKYYVNQCNVRFDD--FLGAMRAIGN 517
            :.|||..|:..|||.:||.:|:.||..|..:|.||.||...|:...|.:.:.:  ..||:.|:..
Zfish   474 KQDHHSIWINGCIGARNHPFFVLFLVALNFLCIWMFYGSITYWSRHCPLHYSEEGIWGALTALMG 538

  Fly   518 CDAWVGWVMGNALLHMSWVILLTICQTYQVICLGMTTNERMNRGRYRHFQAK------GGHSPFT 576
            |..|:.:|......|.:|..:|.:.|.||:..||:||:||.|   ..|.|.|      ...:||.
Zfish   539 CSPWLLYVFCFVFFHTTWASILLVLQLYQIAFLGLTTSERAN---LMHRQRKLPQAVSLRQNPFN 600

  Fly   577 RGPIQNLVDFLECSCFGLVQPKRVDW 602
            .|.::|||:|.:....||.:|..:||
Zfish   601 HGVVKNLVNFFQWRFCGLCKPMVLDW 626

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hip14	NP_001261910.1	ANKYR	<52..246	CDD:440430	96/193 (50%)
		ANK repeat	77..108	CDD:293786	20/30 (67%)
		ANK repeat	110..142	CDD:293786	20/31 (65%)
		ANK repeat	144..175	CDD:293786	12/30 (40%)
		ANK repeat	177..209	CDD:293786	10/31 (32%)
		ANK repeat	212..244	CDD:293786	11/31 (35%)
		DHHC	426..559	CDD:396215	51/134 (38%)
zdhhc13	NP_001008650.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..73		9/33 (27%)
		ANKYR	75..292	CDD:440430	102/217 (47%)
		ANK repeat	76..102	CDD:293786	16/25 (64%)
		ANK repeat	104..135	CDD:293786	20/30 (67%)
		ANK 1. /evidence=ECO:0000255	104..133		19/28 (68%)
		ANK repeat	137..169	CDD:293786	20/31 (65%)
		ANK 2. /evidence=ECO:0000255	138..167		20/28 (71%)
		ANK 3. /evidence=ECO:0000255	171..200		10/28 (36%)
		ANK repeat	176..202	CDD:293786	10/25 (40%)
		ANK repeat	204..236	CDD:293786	10/31 (32%)
		ANK 4. /evidence=ECO:0000255	204..234		10/29 (34%)
		ANK repeat	239..270	CDD:293786	11/31 (35%)
		ANK 5. /evidence=ECO:0000255	239..268		10/29 (34%)
		DHHC	450..580	CDD:396215	50/129 (39%)