Protein Alignment PolD1 and rev3l

DIOPT Version :10

• Sequence 1: NP_524099.2
• Gene: PolD1 / 39746
• FlyBaseID: FBgn0263600
• Length: 1092
• Species: Drosophila melanogaster
• Sequence 2: XP_068071713.1
• Gene: rev3l / 569100
• ZFINID: ZDB-GENE-050302-55
• Length: 2964
• Species: Danio rerio
• Alignment Length: 1195
• Identity: 313/1195 - (26%)
• Similarity: 492/1195 - (41%)
• Gaps: 270/1195 - (22%)

  Fly    11 SNGHAKKPRNPDDDEE---------MGFEAELAAFENS--------EDMDQTLLMGD----GPEN 54
            |..|.|:|....:.:.         :.|....||..:|        :|:|:|   .|    .|.|
Zfish  1898 SENHDKRPEKNSESQHNSRNDFCSPIHFSPVKAASSDSSPSSVKCVQDIDKT---KDCRITSPPN 1959

  Fly    55 QTTSERW-SRPPPPELDPSKHNLE--FQQLDVENYLGQPL-----------PGMPGAQ------- 98
            ......| ..|...|.|..|.||.  .|.|.::..|.:.|           |...|.:
Zfish  1960 SPEISTWQDSPDEVEQDEDKENLTGGLQPLSMDQNLNETLLENAESKDHLSPSFFGIKGLVSDVR 2024

  Fly    99 ----IGPVPVVRMFGVTMEGNSVCCHVHGFCPYFYIEAPSQFEEHHCEKLQKALDQKVIADIRNN 159
                :...||.|......|.:|        |      :|.:.|:..|.      .|::......|
Zfish  2025 CSHLLHSTPVQRRNSTDDEASS--------C------SPVRHEDTECR------SQRLHQRSNKN 2069

  Fly   160 KDNVQEAVLMVELVEKLNIHGYNGDKKQRYIKISVTLPRFVAAASRLLKKEVIMSEIDFQDCRAF 224
            |:.::..:|..::..:|               |::.:|          |||  .|:|:..   :|
Zfish  2070 KNALRRVLLSTQVKNQL---------------INMNVP----------KKE--NSQIEGP---SF 2104

  Fly   225 ENNIDFDIRFMVDTDVVGCNWIELPMGHWRIRNSHSKPLPESRCQIEVDVAFDRFISHEPEGEWS 289
            .|:..|.:..                          :.|.|::.            .||
Zfish  2105 CNSYGFKVSM--------------------------QNLQEAKA------------LHE------ 2125

  Fly   290 KVAPFRILSFDIECAGRKGIFPEAKIDP--------------------------VIQIANMVIRQ 328
             |....::|.::....|:.:.|:.:.||                          ||...:....|
Zfish  2126 -VQHLTLMSMELHARTRRNLEPDPEFDPICALFYCLSSDVLLHDSGTTRIEGAIVIDKESCTSAQ 2189

  Fly   329 GERE--PFIRNVFTLNECAPIIGSQV--LCHDKETQMLDKWSAFVREVDPDILTGYNINNFDFPY 389
            ..|.  ||      |..|. :.|..|  .|.:||  :.::.|..:|:.|||||.||.:....:.|
Zfish  2190 ASRSSTPF------LFRCG-VTGLPVTYTCDEKE--LFEEVSNIIRKYDPDILVGYEVQMHSWGY 2245

  Fly   390 LLNRAAHLKVRNFEYLGRIKNIRSVIKEQMLQSKQMGRRENQYVNFEGRVPFDLLFVLLRDYKLR 454
            ||.||:.|.|...:.|.|:.. .|.....:.:..:.|......::..||:..::..::..:..|.
Zfish  2246 LLQRASTLGVNLCQQLSRVPG-DSQQNHFIPEKDEYGAETMTEIHITGRIILNIWRIMKTEAALN 2309

  Fly   455 SYTLNAVSYHFLQEQKEDVHHSIITDLQNGDEQTRRRLAMYCLKDAYL-----PLRLLEKLMAIV 514
            :||...|::|.|.::.....|..::|..:      ..|..:.:.|.|:     .::||::...|.
Zfish  2310 NYTFENVAFHLLHQRYPLYSHRTLSDWFD------THLHRWKVMDHYVSRVCGTVQLLQQQDIIG 2368

  Fly   515 NYMEMARVTGVPLESLLTRGQQIKVLSQLLRKAKTKGFIMPSYTSQGSDEQYEG---ATVIEPKR 576
            ...|:|||.|:....:||||.|.:|.|.:||.||...:|..:.::|...:|...   ..|:||:.
Zfish  2369 RTSELARVFGIQFYHVLTRGSQYRVESMMLRVAKPMNYIPVTPSTQQRAQQRAAQCIPLVMEPES 2433

  Fly   577 GYYADPISTLDFASLYPSIMMAHNLCYTTLVLG-----GTREK-------LRQQEN----LQDDQ 625
            .:|::.:..|||.||||||::|:|.||:| .||     ||.::       ||...:    |::|
Zfish  2434 RFYSNSVIVLDFQSLYPSIVIAYNYCYST-CLGHIENLGTYDEFKFGCASLRVPPDLLYQLRND- 2496

  Fly   626 VERTPANNYFVKSEVRRGLLPEILESLLAARKRAKNDLKV-ETDPFKRKVLDGRQLALKISANSV 689
            :..:|....||||.||||:||.:||.:|..|...|..:|. ..|....::||.|||.||:.||..
Zfish  2497 ITVSPNGVAFVKSSVRRGVLPRMLEEILKTRIMVKQSMKAYRNDKALSRLLDARQLGLKLIANVT 2561

  Fly   690 YGFTGAQV-GKLPCLEISGSVTAYGRTMIEMTKNEVESHYTQANGYENNAVVIYGDTDSVMVNFG 753
            :|:|.|.. |::||:|:..|:....|..:|.....|..  |:..|    |.|:||||||:.|...
Zfish  2562 FGYTSANFSGRMPCVEVGDSIVHKARETLERAIKMVND--TKKWG----ARVVYGDTDSMFVLLK 2620

  Fly   754 VKTLERSMELGREAAELVSSKFVHPIKLEFEKVYYPYLLINKKRYAGLYFTRPDTYDKM-DCKGI 817
            ..|.|::.::|.|.||.|::....||||:|||||.|.:|..||||.|..:...|..:.: |.|||
Zfish  2621 GATKEQAFKIGNEIAEAVTATNPKPIKLKFEKVYLPCILQTKKRYVGYMYESVDQENPVFDAKGI 2685

  Fly   818 ETVRRDNSPLVANLMNSCLQKLLIERDPDGAVAYVKQVIADLLCNRIDISHLVITKELAKTDYAA 882
            ||||||..|.|:.::...|:.|...||......||::....::..:..:..|...||     |..
Zfish  2686 ETVRRDGCPGVSKILERSLKLLFESRDISQVKQYVQRQCVKVVEGKASMQDLTFAKE-----YRG 2745

  Fly   883 KQAH--------VELAAKMKKRDPGTAPKLGDRVPYVICAAAKNTPAYQKAEDPLYVLEN-SVPI 938
            ..::        :||..:|...|....|::|:||||||...:...|..|....||.||:: |:.:
Zfish  2746 SGSYRPGACVPALELTRRMMAFDRRLEPRVGERVPYVIVYGSPGVPLIQLVRRPLEVLQDPSLRL 2810

  Fly   939 DATYYLEQQLSKPLLRIFEPILGDNAESILLKGEHTRTRTVVTSKVGGLAGFMTKKTSCLGCKSL 1003
            :||||:.:|:..||.|||. ::|.:..|...:....:.....||...|..|  |||.:.
Zfish  2811 NATYYITKQILPPLARIFN-LIGVDVFSWYHELPRVQRAWSFTSSGRGEEG--TKKGTI------ 2866

  Fly  1004 MPKGYEQACLCPHCEPRMSELYQKEVGAKRELE--------ETFSRLWTE--------CQRCQES 1052
              ..|.....||.|:    ||.|..|.|:...|        ....|||..        |:.|..|
Zfish  2867 --SQYFTTLHCPVCD----ELTQLGVCARCRAEPQCVAVHLHQDLRLWESQQDQLLKICRSCSGS 2925

  Fly  1053 LHEEVICSNRDCPIFYMRQKVRMDL 1077
            ...:|.|.:.||||.|...:|..:|
Zfish  2926 AERQVPCVSLDCPILYKLSRVNRNL 2950

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PolD1	NP_524099.2	PTZ00166	48..1092	CDD:240301	302/1141 (26%)
rev3l	XP_068071713.1	PTZ00166	31..>193	CDD:240301
		DUF4683	729..1110	CDD:464832
		REV3L_RBD	1721..1743	CDD:412083
		DNA_polB_zeta_exo	2127..2361	CDD:99821	51/249 (20%)
		POLBc_zeta	2388..2836	CDD:99917	162/461 (35%)
		zf-C4pol	2875..2942	CDD:464119	21/70 (30%)