Protein Alignment PolD1 and POLE

DIOPT Version :10

• Sequence 1: NP_524099.2
• Gene: PolD1 / 39746
• FlyBaseID: FBgn0263600
• Length: 1092
• Species: Drosophila melanogaster
• Sequence 2: XP_011533097.1
• Gene: POLE / 5426
• HGNCID: 9177
• Length: 2298
• Species: Homo sapiens
• Alignment Length: 1298
• Identity: 238/1298 - (18%)
• Similarity: 412/1298 - (31%)
• Gaps: 482/1298 - (37%)

  Fly     3 GKRKFNGTSNGHAKKPRNPDDDEEMGFEAELAAFENSEDMDQ-TLLMGDGPENQTTSERWSRP-- 64
            |:|:.:..::|.|.:     ||......:.|...|.|:..|: .|..|        .||...|
Human     7 GRRRADPGADGEASR-----DDGATSSVSALKRLERSQWTDKMDLRFG--------FERLKEPGE 58

  Fly    65 --------PPPELDPSKHNLEFQQLDVENYLGQPLPGMPGAQIGPVPVVRMFGVTMEGNSVCCHV 121
                    .|.|:           ||.:..||.              .|..:.:..:|:.....:
Human    59 KTGWLINMHPTEI-----------LDEDKRLGS--------------AVDYYFIQDDGSRFKVAL 98

  Fly   122 HGFCPYFYIEAPSQFEEHHCEK-LQKALDQKVIADIRNNKDNVQEAVLMVELV--EKLNIHGYNG 183
             .:.|||||..     ...||: :...|.:|           .|..:..||.|  |.|::..:..
Human    99 -PYKPYFYIAT-----RKGCEREVSSFLSKK-----------FQGKIAKVETVPKEDLDLPNHLV 146

  Fly   184 DKKQRYIKISV-------------------------TLPRFVAAASRLLKK-----------EVI 212
            ..|:.||::|.                         ....:.|..|.:|::           :.|
Human   147 GLKRNYIRLSFHTVEDLVKVRKEISPAVKKNREQDHASDAYTALLSSVLQRGGVITDEEETSKKI 211

  Fly   213 MSEID-FQDCRAFENNIDFDIRFMVDTDVVGCNWIELPMGHWRIRNSHSKPLPESRCQIEVDVAF 276
            ..::| ..|.|  |.::.:.||..:|        :::.:.||..........|     :|:....
Human   212 ADQLDNIVDMR--EYDVPYHIRLSID--------LKIHVAHWYNVRYRGNAFP-----VEITRRD 261

  Fly   277 DRFISHEPEGEWSKVAPFRILSFDIECAGRKGIFPEAKIDPVIQIANMVIRQG----EREPFIRN 337
            |.....:|.          :|:||||.......||:|:.|.::.|:.|:..||    .||....:
Human   262 DLVERPDPV----------VLAFDIETTKLPLKFPDAETDQIMMISYMIDGQGYLITNREIVSED 316

  Fly   338 V----FTLNE------CAPIIGSQVLCHDKETQMLDKWSAFVREVDPDILTGYNINNFDFPYLLN 392
            :    ||...      |       |.....|..::.:|...|:|..|.|:..||.:.||:|::..
Human   317 IEDFEFTPKPEYEGPFC-------VFNEPDEAHLIQRWFEHVQETKPTIMVTYNGDFFDWPFVEA 374

  Fly   393 RAAHLKVRNFEYLGRIKNIRSVIKEQMLQSKQMGRRENQYVNFEGR--VPFDLLFVLLRDYKL-- 453
            |||               :..:..:|     ::|.:::....::..  :..|.|..:.||..|
Human   375 RAA---------------VHGLSMQQ-----EIGFQKDSQGEYKAPQCIHMDCLRWVKRDSYLPV 419

  Fly   454 RSYTLNA-----VSYHFLQEQKEDVHHSIITDLQNGDEQTRRRLAMYCLKDAYLPLRLLEKLMAI 513
            .|:.|.|     :.|..::...||:       .:...||. :.||.|.:.||.....|   .|..
Human   420 GSHNLKAAAKAKLGYDPVELDPEDM-------CRMATEQP-QTLATYSVSDAVATYYL---YMKY 473

  Fly   514 VNYMEMARVTGVPLE--SLLTRGQQIKVLSQLLRKAKTKGFIMPS--------YTSQG---SDEQ 565
            |:....|..|.:|:|  .:|.:|......:.|:.:|.....|.|:        .|..|   ..|.
Human   474 VHPFIFALCTIIPMEPDEVLRKGSGTLCEALLMVQAFHANIIFPNKQEQEFNKLTDDGHVLDSET 538

  Fly   566 YEGATVIEPKRGYY-----------------------------------------------ADPI 583
            |.|..|...:.|.:                                               .|.|
Human   539 YVGGHVEALESGVFRSDIPCRFRMNPAAFDFLLQRVEKTLRHALEEEEKVPVEQVTNFEEVCDEI 603

  Fly   584 ST-------------------LDFASLYPSIMMAHNLCYTTLVLGGT------------------ 611
            .:                   ||..::||:|::.:.|..:.:|...|
Human   604 KSKLASLKDVPSRIECPLIYHLDVGAMYPNIILTNRLQPSAMVDEATCAACDFNKPGANCQRKMA 668

  Fly   612 ------------REKLRQQENLQDDQ----VERTPANNYF-------VKSEVRRGL--------- 644
                        .|..|.|..|:.::    ....||..:.       .|.|.||..
Human   669 WQWRGEFMPASRSEYHRIQHQLESEKFPPLFPEGPARAFHELSREEQAKYEKRRLADYCRKAYKK 733

  Fly   645 --LPEILESLLAARKRAKNDLKVET---------------DPFKRK------------------- 673
              :.::.|.|....:| :|...|:|               ..:|:|
Human   734 IHITKVEERLTTICQR-ENSFYVDTVRAFRDRRYEFKGLHKVWKKKLSAAVEVGDAAEVKRCKNM 797

  Fly   674 --VLDGRQLALKISANSVYGFTGAQVGKLPCLEISGSVTAYGRTMIEMTKNEVES---------- 726
              :.|..|||.|...||.||:...:..:...:|::|.|...|..:|...:..:|.
Human   798 EVLYDSLQLAHKCILNSFYGYVMRKGARWYSMEMAGIVCFTGANIITQARELIEQIGRPLELDTD 862

  Fly   727 --HYTQANGYENNAV------------VIYGDTDSVMVNFGVK---TLERSMELGREAAELVSSK 774
              .....|.:..|.|            :.|   ...|:|..||   |.::..||...::....::
Human   863 GIWCVLPNSFPENFVFKTTNVKKPKVTISY---PGAMLNIMVKEGFTNDQYQELAEPSSLTYVTR 924

  Fly   775 FVHPIKLEFEKVYYPYLLI-----------NKKRYAGLYFTRPDTYDKMDCKGIETVRRDNSPLV 828
            ..:.|   |.:|..|||.:           .|||||  .|....:..::  ||.|..||....|:
Human   925 SENSI---FFEVDGPYLAMILPASKEEGKKLKKRYA--VFNEDGSLAEL--KGFEVKRRGELQLI 982

  Fly   829 ANLMNSCLQKLL----IERDPDGAVAYVKQVIADLLCNRI------DISHLV-----ITKELAKT 878
            ....:|..:..|    :| :..|:||.|.....|:|.::.      ::..|:     ::::|  .
Human   983 KIFQSSVFEAFLKGSTLE-EVYGSVAKVADYWLDVLYSKAANMPDSELFELISENRSMSRKL--E 1044

  Fly   879 DYA-AKQAHVELAAKMKKRDPGTAPKLGDRV--------PYVICAAAKNTPAYQKAEDPLYVLEN 934
            ||. .|...:..|.::       |..|||::        .|:|....:.:|..::| .||.:.:.
Human  1045 DYGEQKSTSISTAKRL-------AEFLGDQMVKDAGLSCRYIISRKPEGSPVTERA-IPLAIFQA 1101

  Fly   935 SVPI-----------------------DATYYLE----------------QQLSKPLLRIFEP 958
            ...:                       |..||:|                ||:..|:.|:..|
Human  1102 EPTVRKHFLRKWLKSSSLQDFDIRAILDWDYYIERLGSAIQKIITIPAALQQVKNPVPRVKHP 1164

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PolD1	NP_524099.2	PTZ00166	48..1092	CDD:240301	227/1252 (18%)
POLE	XP_011533097.1	DNA_polB_epsilon_exo	268..471	CDD:99822	55/250 (22%)
		POLBc_epsilon	531..1153	CDD:99918	107/643 (17%)
		DUF1744	1538..1925	CDD:462493