Protein Alignment PolD1 and PolA1

DIOPT Version :10

• Sequence 1: NP_524099.2
• Gene: PolD1 / 39746
• FlyBaseID: FBgn0263600
• Length: 1092
• Species: Drosophila melanogaster
• Sequence 2: NP_536736.2
• Gene: PolA1 / 42553
• FlyBaseID: FBgn0259113
• Length: 1488
• Species: Drosophila melanogaster
• Alignment Length: 1251
• Identity: 276/1251 - (22%)
• Similarity: 486/1251 - (38%)
• Gaps: 286/1251 - (22%)

  Fly    16 KKPRNPDDDEEMGFEAELAAFENSEDMDQTLLMGDGPENQTTSERWSRPPPPELD-PSKHNL--- 76
            |...:|..|.||.|.. |...||..|:::|.......:.:|.:|:.|:....|.. |.|...
  Fly   255 KATEDPFSDNEMDFSC-LDDDENQFDVEKTQQTEKVSQTKTAAEKTSQSKVAEKSAPKKETTGSP 318

  Fly    77 -EFQQLDVENYLG----------------------------------------QPLPGMPGAQIG 100
             |.:..|:...|.                                        .|:. |||.
  Fly   319 KESESEDISRLLNNWESICQMDDDFEKSVLTTEQDSTISSDQQLRFWYWEAYEDPVK-MPGE--- 379

  Fly   101 PVPVVRMFGVTMEGNSVCCHVHGFCPYFYIEAPSQFEEHHCEKLQKALDQKV-IADIRNNKDNVQ 164
                |.:||.|.:|.|||..|.......|: .|.||......|  :...||| :|||....|:..
  Fly   380 ----VFLFGRTADGKSVCLRVQNINRVLYL-LPRQFLLDPISK--EPTKQKVTVADIYKEFDSEV 437

  Fly   165 EAVLMVEL----------------------VEKLNIHGYNGDKKQRYIKISVTLPRFVAAASRLL 207
            ...|.:|.                      .:.|.:| |:|.|         .||...|.
  Fly   438 ANQLKLEFFRSRKVTKSFAHHAIGIEVPQSCDYLEVH-YDGKK---------PLPNLSAD----- 487

  Fly   208 KKEVIMSEIDFQDCRAFENNIDFDIRFMVDTDVVGCNWIELPMGHWRIRNSHSKPLPESRCQIEV 272
            ||...::.|......|.|       ||::|..:.|..|::       :......|.|.|.|..||
  Fly   488 KKYNSIAHIFGATTNALE-------RFLLDRKIKGPCWLQ-------VTGFKVSPTPMSWCNTEV 538

  Fly   273 DVAFDRFIS-HEPEGEWSKVAPFRILSFDIECAGRKGIFPEAKIDPVIQIANM------VIRQGE 330
            .:...:.:. .:.:|:.:...|..:||.::    |..:.|:...:.:..|:.:      :.|...
  Fly   539 TLTEPKNVELVQDKGKPAPPPPLTLLSLNV----RTSMNPKTSRNEICMISMLTHNRFHIDRPAP 599

  Fly   331 REPFIRNVFTLN-------------ECAPIIGSQVLCHDKETQMLDKWSAFVREVDPDILTGYNI 382
            :..|.|::..|.             |.|....:.|..||.|..:|..:.|..:::|.|::..::.
  Fly   600 QPAFNRHMCALTRPAVVSWPLDLNFEMAKYKSTTVHKHDSERALLSWFLAQYQKIDADLIVTFDS 664

  Fly   383 NNFDFPYLLNRAAHLKVRNFEYLGRIKNIRSVIKEQMLQSKQMGRRENQYVNFEGRVPFDLLFVL 447
            .:.....:.::...||:..:..:||::           .|:..|:|..::  |.||:..|:....
  Fly   665 MDCQLNVITDQIVALKIPQWSRMGRLR-----------LSQSFGKRLLEH--FVGRMVCDVKRSA 716

  Fly   448 LRDYKLRSYTLNAVSYHFL---QEQKEDVHHSIITDLQNGDEQTRRRLAMYCLKDAYLPLRLLEK 509
            ....:.|||.|..:....|   :.::.:|:...:.::....|...:.:::....::|| |||:.:
  Fly   717 EECIRARSYDLQTLCKQVLKLKESERMEVNADDLLEMYEKGESITKLISLTMQDNSYL-LRLMCE 780

  Fly   510 LMAIVNYMEMARVTGVPLESLLTRGQQIKVLSQLLRKAKTKGFIMP--------------SYTSQ 560
            |..:...:::..:.|..:...|..|:..:....||.....|.:|:|              ..|..
  Fly   781 LNIMPLALQITNICGNTMTRTLQGGRSERNEFLLLHAFHEKNYIVPDKKPVSKRSGAGDTDATLS 845

  Fly   561 GSD--------EQYEGATVIEPKRGYYADPISTLDFASLYPSIMMAHNLCYTTLVLGGTREKLRQ 617
            |:|        ..|.|..|:||.||.|...:..:||.||||||:..:|:|:||:
  Fly   846 GADATMQTKKKAAYAGGLVLEPMRGLYEKYVLLMDFNSLYPSIIQEYNICFTTV----------- 899

  Fly   618 QENLQDDQVERTPANNYFVKSEVRRGLLPEILESLLAARKRAKNDLKV-ETDPFKRKVLDGRQLA 681
            |:.:..|::...|      .|:...|:||..|:.|:.:||..|..:.. :..|..:.....||:|
  Fly   900 QQPVDADELPTLP------DSKTEPGILPLQLKRLVESRKEVKKLMAAPDLSPELQMQYHIRQMA 958

  Fly   682 LKISANSVYGFTGAQVGKLPCLEISGSVTAYGRTMIEMTKNEVESHYTQANGYENNAVVIYGDTD 746
            ||::|||:||..|....:.....::..||..||.::..|:..|:         :.|..|:|||||
  Fly   959 LKLTANSMYGCLGFAHSRFFAQHLAALVTHKGREILTNTQQLVQ---------KMNYDVVYGDTD 1014

  Fly   747 SVMVNFGVKTLERSMELGREAAELVSSKFVHPIKLEFEKVYYPYLLINKKRYAGLYFTRPDTYD- 810
            |:|:|..:...::..::|....:.| :|....::|:.:.|:...||:.||:||.:..::....:
  Fly  1015 SLMINTNITDYDQVYKIGHNIKQSV-NKLYKQLELDIDGVFGCLLLLKKKKYAAIKLSKDSKGNL 1078

  Fly   811 --KMDCKGIETVRRDNSPLVANLMNSCLQKLL----IERDPDGAVAYVKQVIADLLCNRIDISHL 869
              :.:.||::.||||.|.|...:..:.|.::|    :|...|...|.::::...:....:.:...
  Fly  1079 RREQEHKGLDIVRRDWSQLAVMVGKAVLDEVLSEKPLEEKLDAVHAQLEKIKTQIAEGVVPLPLF 1143

  Fly   870 VITKELAKT--DYA--AKQAHVELAAKMKKRDPGTAPKLGDRVPYVICAAAKNTPAYQKAE--DP 928
            ||||:|.:|  :||  |...||::|.:| .|:.....|.||.|.||||.......|.|:|.  |.
  Fly  1144 VITKQLTRTPQEYANSASLPHVQVALRM-NRERNRRYKKGDMVDYVICLDGTTNAAMQRAYHLDE 1207

  Fly   929 LYVLEN-SVPIDATYYLEQQLSKPLLRIFEPILGDNAESIL---------LKGEHTRTRTVVTSK 983
            |...|: .:.:|..|||..|:...:.|:.|.:.|.:|..|.         .:....||:...|.:
  Fly  1208 LKTSEDKKLQLDTNYYLGHQIHPVVTRMVEVLEGTDASRIAECLGMDPTKFRQNAQRTQRENTEQ 1272

  Fly   984 VGGLAGFMTK----------KTSCLGCKS--LMPKGYE-----------QACLCPHCEPR----M 1021
            ..|.:...|.          :..|:.||:  ||...|.           |.|....|:..    :
  Fly  1273 SEGESLLKTTLQLYRLCEPFRFQCVTCKTEQLMASAYRPGPSNSHIAVLQQCAKSECQTAPIQYL 1337

  Fly  1022 SELYQKEVGAKRELEETFSRLWTECQRCQESLHEEVICSNRDC---------------PI----- 1066
            :.:..:...:.|:..:.|.:.|             ::|.:.||               |:
  Fly  1338 ASVRNQLQLSMRQYVQRFYKNW-------------LVCDHPDCNFNTRTHSLRKKSHRPLCQKCR 1389

  Fly  1067 --FYMRQKVRMDLDNQ 1080
              ..:||....||.||
  Fly  1390 SGSLLRQYTERDLYNQ 1405

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PolD1	NP_524099.2	PTZ00166	48..1092	CDD:240301	265/1219 (22%)
PolA1	NP_536736.2	pol2	52..1237	CDD:273159	245/1068 (23%)
		zf-DNA_Pol	1286..1459	CDD:462651	22/133 (17%)