Protein Alignment PolD1 and Pole

DIOPT Version :10

• Sequence 1: NP_524099.2
• Gene: PolD1 / 39746
• FlyBaseID: FBgn0263600
• Length: 1092
• Species: Drosophila melanogaster
• Sequence 2: NP_001100622.2
• Gene: Pole / 304573
• RGDID: 1594540
• Length: 2283
• Species: Rattus norvegicus
• Alignment Length: 1201
• Identity: 222/1201 - (18%)
• Similarity: 382/1201 - (31%)
• Gaps: 446/1201 - (37%)

  Fly   126 PYFYIEAPSQFEEHHCEKLQKALDQKVIADIRNNKDNVQEAVLMVELVEKLNIHGYNGDKKQRYI 190
            |||||.|....:......|.|....|:.     ..:||.:        |.|::..:....|:.||
  Rat   102 PYFYIAARKGCDREVSSFLSKKFQGKIA-----KLENVPK--------EDLDLPNHLVGLKRSYI 153

  Fly   191 KIS--------------------------------VTLPRFVAAASRLLKKEVIMSEIDFQ---- 219
            |:|                                ..|...:...|.:..:|....:|..|
  Rat   154 KLSFHTVEDLVKVRKEISPAVKKNREQDHASDEYTTMLSSILQGGSLITDEEETSKKIADQLDNI 218

  Fly   220 -DCRAFENNIDFDIRFMVDTDVVGCNWIELPMGHW---RIRNSHSKPLPESRCQIEVDVAFDRFI 280
             |.|  |.::.:.||..:|        :.:.:.||   |.|.:          ...|::|....:
  Rat   219 VDMR--EYDVPYHIRLSID--------LRIHVAHWYNVRFRGN----------AFPVEIARRDDL 263

  Fly   281 SHEPEGEWSKVAPFRILSFDIECAGRKGIFPEAKIDPVIQIANMVIRQG----EREPFIRNV--- 338
            ...|:       |. :|:||||.......||:|:.|.::.|:.|:..||    .||....::
  Rat   264 VERPD-------PV-VLAFDIETTKLPLKFPDAETDQIMMISYMIDGQGYLITNREIVSEDIEDF 320

  Fly   339 -FTLNE------CAPIIGSQVLCHDKETQMLDKWSAFVREVDPDILTGYNINNFDFPYLLNRAAH 396
             ||...      |       |.....|..::.:|...::|..|.|:..||.:.||:|::..|||.
  Rat   321 EFTPKPEYEGPFC-------VFNEPDEVHLIQRWFEHIQETKPTIMVTYNGDFFDWPFVEARAAI 378

  Fly   397 LKVRNFEYLGRIKNIRSVIKEQMLQSKQMGRRENQYVNFEGRVPFDLLFVLLRDYKL--RSYTLN 459
            ..:..::.:|..|:.:...|....                  :..|.|..:.||..|  .|:.|.
  Rat   379 HGLSMYQEIGFQKDSQGEYKAPQC------------------IHMDCLRWVKRDSYLPVGSHNLK 425

  Fly   460 A-----VSYHFLQEQKEDVHHSIITDLQNGDEQTRRRLAMYCLKDAYLPLRLLEKLMAIVNYMEM 519
            |     :.|..::...||:       .:...||. :.||.|.:.||.....|   .|..|:....
  Rat   426 AAAKAKLGYDPVELDPEDM-------CRMATEQP-QTLATYSVSDAVATYYL---YMKYVHPFIF 479

  Fly   520 ARVTGVPLE--SLLTRGQQIKVLSQLLRKAKTKGFIMPSYTSQGSD-----------EQYEGATV 571
            |..|.:|:|  .:|.:|......:.|:.:|.....|.|:...|..:           |.|.|..|
  Rat   480 ALCTIIPMEPDEVLRKGSGTLCEALLMVQAFHANIIFPNKQEQEFNKLTDDGHVLDAETYVGGHV 544

  Fly   572 IEPKRGYY-----------------------------------------------ADPIST---- 585
            ...:.|.:                                               .:.|.|
  Rat   545 EALESGVFRSDIPCRFRMNPAAFDFLLQRVEKTMRHAIEEEEKVPVEQATNFQEVCEQIKTKLTS 609

  Fly   586 ---------------LDFASLYPSIMMAHNLCYTTLVLGGT------------------------ 611
                           ||..::||:|::.:.|..:.:|...|
  Rat   610 LKDVPNRIECPLIYHLDVGAMYPNIILTNRLQPSAIVDEATCAACDFNKPGATCQRKMAWQWRGE 674

  Fly   612 ------REKLRQQENLQDDQ----VERTPANNYF-------VKSEVRRGL-----------LPEI 648
                  .|..|.|..|:.::    ....||..:.       .|.|.||..           :.::
  Rat   675 FMPASRSEYHRIQHQLESEKFPPLFPEGPARAFHELSREEQAKYEKRRLADYCRKAYKKIHMTKV 739

  Fly   649 LESLLAARKRAKNDLKVET---------------DPFKRK---------------------VLDG 677
            .|.|....:| :|...|:|               ..:|:|                     :.|.
  Rat   740 EERLTTICQR-ENSFYVDTVRAFRDRRYEFKGLHKVWKKKLSAAVEVGDASEVKRCKNMEILYDS 803

  Fly   678 RQLALKISANSVYGFTGAQVGKLPCLEISGSVTAYGRTMIEMTKNEVES------------HYTQ 730
            .|||.|...||.||:...:..:...:|::|.|...|..:|...:..:|.            ....
  Rat   804 LQLAHKCILNSFYGYVMRKGARWYSMEMAGIVCFTGANIITQARELIEQIGRPLELDTDGIWCVL 868

  Fly   731 ANGYENNAVVIYGDTDSV------------MVNFGVK---TLERSMELGREAAELVSSKFVHPIK 780
            .|.:..|.|:   .|.:|            |:|..||   |..:..||...::....::..:.|
  Rat   869 PNSFPENFVI---KTTNVKKPKLTISYPGAMLNIMVKEGFTNHQYQELTEPSSLTYVTRSENSI- 929

  Fly   781 LEFEKVYYPYLLI-----------NKKRYAGLYFTRPDTYDKMDCKGIETVRRDNSPLVANLMNS 834
              |.:|..|||.:           .|||||  .|....:..::  ||.|..||....|:....:|
  Rat   930 --FFEVDGPYLAMILPASKEEGKKLKKRYA--VFNEDGSLAEL--KGFEVKRRGELQLIKIFQSS 988

  Fly   835 CLQKLL----IERDPDGAVAYVKQVIADLLCNRI------DISHLV-----ITKELAKTDYA-AK 883
            ..:..|    :| :...:||.|.....|:|.::.      ::..|:     ::::|  .||. .|
  Rat   989 VFEAFLKGSTLE-EVYASVAKVADYWLDVLYSKAANMPDSELFELISENRSMSRKL--EDYGEQK 1050

  Fly   884 QAHVELAAKMKKRDPGTAPKLGDRV--------PYVICAAAKNTPAYQKAEDPLYVLENSVPI-- 938
            ...:..|.::       |..|||::        .|:|....:.:|..::| .||.:.:....:
  Rat  1051 STSISTAKRL-------AEFLGDQMVKDAGLSCRYIISRKPEGSPVTERA-IPLAIFQAEPTVRK 1107

  Fly   939 ---------------------DATYYLE----------------QQLSKPLLRIFEP------IL 960
                                 |..||:|                ||:..|:.|:..|      :|
  Rat  1108 HFLRKWLKSSSLQDFDIRTILDWDYYIERLGSAIQKIITIPAALQQVKNPVPRVKHPDWLHKKLL 1172

  Fly   961 GDN--------AESILLKGEHTRTRTVVTSK 983
            ..|        :|..:|:|:    |.:|.::
  Rat  1173 EKNDIYKQKKISELFVLEGK----RQIVMAQ 1199

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PolD1	NP_524099.2	PTZ00166	48..1092	CDD:240301	222/1201 (18%)
Pole	NP_001100622.2	DNA_polB_epsilon_exo	268..471	CDD:99822	55/246 (22%)
		POLBc_epsilon	531..1153	CDD:99918	106/643 (16%)
		DUF1744	1525..1924	CDD:462493