Protein Alignment PolD1 and rev3

DIOPT Version :10

• Sequence 1: NP_524099.2
• Gene: PolD1 / 39746
• FlyBaseID: FBgn0263600
• Length: 1092
• Species: Drosophila melanogaster
• Sequence 2: NP_594068.1
• Gene: rev3 / 2543358
• PomBaseID: SPAC688.10
• Length: 1480
• Species: Schizosaccharomyces pombe
• Alignment Length: 1503
• Identity: 317/1503 - (21%)
• Similarity: 529/1503 - (35%)
• Gaps: 537/1503 - (35%)

  Fly    85 NYLGQPLPGMPGAQIGPVPVVRMFGVTMEGNSVCCHVHGFCPYFYIEAPSQFEEHHCE------K 143
            :::|:.|| ....::..|||:|:||:..|..:|||.:|...||.|:|..|..|....|      :
pombe    20 DFVGKDLP-TANEELTTVPVIRVFGLNEEAETVCCFIHNVFPYIYVEYSSFAETLDLEVPDFLSQ 83

  Fly   144 LQKALDQKVIADIRNNKDNVQEAVLMVELVEKLNIHGYNGDKKQRYIKISVTLPRFVAAASRLLK 208
            ||.:::..:....|.|.:..:.||..|:||:.:..:||: ...|:::||.:..|:.......|.:
pombe    84 LQTSINYALALAARANPETYKPAVQSVQLVKGIPFYGYS-FCFQKFLKICLFSPKNRDRLVDLFR 147

  Fly   209 KEVIMSEIDFQDCRAFENNIDFDIRFMVDTDVVGCNWIEL------------------------- 248
            :..|::::    .:.:|:::.:.::||||.::.||..|:|
pombe   148 QGAILNKV----IQVYESHLPYLLQFMVDHNLYGCAPIDLDDSIIKRDDLLSFCNVEVHVSPNAI 208

  Fly   249 ----------------------------------------------------------------- 248
                                                                             
pombe   209 LNACWLSERNIHTDLYETHASSPNSLLVTSLAEIWKSEASRRNLTSSDETNSFSKLHQSQFGLKE 273

  Fly   249 -----PMG--HWR--------IRN-------SHS--------KPLPE------------------ 265
                 |..  ||:        ::|       |.|        .|.||
pombe   274 ESSHEPRSSQHWKNEVAMKDLLKNLIKSKLESSSDVNTPLIFDPWPELPTIYSAIHTKDYVRPSQ 338

  Fly   266 ---SRCQIEV----------------------------------------DVAFDRFISHEPEGE 287
               |..||.|                                        |..||.|...||..:
pombe   339 NDISVSQISVDEKICTSYESLPKIQLEQNTAPVIESSFEQLDSELERILGDTLFDSFPYVEPNVD 403

  Fly   288 WSK----------------------------------VAPF--------------RILSF----- 299
            .||                                  :.||              |.:.|
pombe   404 RSKFPKSPLNSSQEVTIHSSQDRQSPPSSPLKDVPSQINPFSPSLRLKGGSPITKREIEFCRDLP 468

  Fly   300 -----------DIECAGRK---------------------------------------------- 307
                       |...||::
pombe   469 NRPTSSEPNQGDTRKAGKRLKYSRNLDDYHICTQIPEDYSPKFLSQHESFVYKQQPPSTDDLYGT 533

  Fly   308 -------------------------------------GI----FPE----------AKIDPV--- 318
                                                 |:    .||          .:::|:
pombe   534 MKKLKIPFSIPTNVHYSSEKDIPSYSQEYLGKSHYPIGVSSRYLPEFQSDGSVSEKVRLNPLKLS 598

  Fly   319 -----------------IQIANMVIRQG-----------------EREPFIRNVFTLNECAPIIG 349
                             :.::|:..::.                 .::|:        .|..|:.
pombe   599 NFHGERTWQYIKPAPLAVDLSNLESKEAVSEEIQSPQRLSRSKVFRKDPY--------SCVRILA 655

  Fly   350 SQVLC-----------------------HDKETQMLDKWSAFV---------------------- 369
            .::.|                       .|..:.|:|:....|
pombe   656 LELFCCSHGGLTPDPTKDSIECCFWAYQEDVNSSMIDRVGFIVVDKSASNSSFGRSFPSCTVLVV 720

  Fly   370 --------------REVDPDILTGYNINNFDFPYLLNRAAHLKVRNFEY-----LGRIKNIRSVI 415
                          |::||.|:.||.::|..:.||:.||::    .|.|     |.|:|
pombe   721 NSELELINEVIGLNRQLDPTIVCGYEVHNSSWGYLIERASY----RFNYDLPEQLSRLK------ 775

  Fly   416 KEQMLQSKQMGRRENQY-------VNFEGRVPFDLLFVLLRDYKLRSYTLNAVSYHFLQEQKEDV 473
               ........::||.:       :|..||...::..:|..:..|.:|:|..|..:..::|....
pombe   776 ---CTSKANFAKKENAWKYTTTSSINIVGRHVLNIWRILRGEVNLLNYSLENVVLNIFKKQTPYY 837

  Fly   474 HHSIITDL-QNGDEQTRRRLAMYCLKDAYLPLRLLEKLMAIVNYMEMARVTGVPLESLLTRGQQI 537
            :.:....| |:.....::.|..|.|......|.:|.....:....|.||:.|:...|:::||.|.
pombe   838 NQADKVHLWQSSRFHEKQILLNYMLNRTRYCLEILSACAIVTKIREQARIIGIDFMSVISRGSQF 902

  Fly   538 KVLSQLLRKAKTKGFIMPSYTSQGSDEQ--YEG-ATVIEPKRGYYADPISTLDFASLYPSIMMAH 599
            ||.|.:.|.||.:.:|.||.:::...||  .|. ..|:|||...|.:|:..|||.||||||::|:
pombe   903 KVESIMFRIAKPENYIFPSPSAKQVAEQNALEALPLVMEPKSDLYNNPVVVLDFQSLYPSIIIAY 967

  Fly   600 NLCYTTL-----VLGGTREKL--------RQQENLQDDQVERTPANNYFVKSEVRRGLLPEILES 651
            ||||:|.     ::.| :.||        ....||..:.|..:|....:||..||:.||.::||.
pombe   968 NLCYSTCLGPVKIVNG-KVKLGFMFHSSNPNIVNLIKNDVYISPNGYAYVKENVRKSLLAKMLEE 1031

  Fly   652 LLAARKRAKNDLKVETDPFKRKVLDGRQLALKISANSVYGFTGAQV-GKLPCLEISGSVTAYGRT 715
            |:..|...|..:|.....:..|||:.||||||:.||..||:|.|.. |::||.||:.::...||
pombe  1032 LIETRNMVKRGMKDCDSDYVNKVLNSRQLALKLIANVTYGYTSASFSGRMPCSEIADTIVETGR- 1095

  Fly   716 MIEMTKNEVESHYTQANGYEN-----NAVVIYGDTDSVMVNFGVKTLERSMELGREAAELVSSKF 775
                   |:.|:..:   |.|     :|.|:||||||:.|.....|.|::.::|::.|..::|:|
pombe  1096 -------EILSYSLE---YINTLDFCHAKVVYGDTDSLFVELPGATKEQAFDIGQQLANNITSRF 1150

  Fly   776 VHPIKLEFEKVYYPYLLINKKRYAGLYFTRPDTYDKM-DCKGIETVRRDNSPLVANLMNSCLQKL 839
            ..||:|:|||:|:|..|:.||||.|..|........: :.|||||||||.:|:...|:..||:.|
pombe  1151 PSPIRLKFEKIYFPCFLLAKKRYVGFKFESVSQKAPIFEAKGIETVRRDGTPVQQQLLRRCLEIL 1215

  Fly   840 LIERDPDGAVAYVKQVIADLLCNRIDISHLVITKELAKTDY---AAKQAHVELAAKMKKRDPGTA 901
            ...:|........:.|...::...:.:.....:||:....|   :.......:|.::..:||...
pombe  1216 FKTKDLSTVKKEFQNVCYQIMSGNVPVMDFCFSKEVRLEKYKELSTAPPGAVMARRLMTKDPRRE 1280

  Fly   902 PKLGDRVPYVICAAAKNTPAYQKAEDPLYVLENSV-PIDATYYLEQQLSKPLLRIFEPILGDNAE 965
            |:.|:||||:|.|||..|....::..|...|.:|. .:|..||:...|..||.| |..:||.:|:
pombe  1281 PQYGERVPYLIIAAAPGTTLANRSVAPEEFLSSSFSQLDINYYINNSLIPPLDR-FLNLLGASAQ 1344

  Fly   966 SILLKGEHTRTRTVVTSKVGG------LAGFMTKK--TSCLGCK-SLMPKGYEQACLCPHCEPRM 1021
            |...:....||...:|..|.|      |..|:.:|  :|||... .::|.....  ||..|....
pombe  1345 SWYHEMPKPRTSLKLTETVKGGIQKKTLDTFLMEKLCSSCLKNNIEIIPDKINS--LCSDCLKNP 1407

  Fly  1022 SELYQKEVGAKRELEETFSRLWTECQRCQE-SLHEEVICSNRDCPIFYMRQKVRMDLDNQEKRVL 1085
            .....|.|.......:..|.|:..|:.|.: |..:.|:|.:..|.::|.|.|.......|.:.:.
pombe  1408 CATISKAVTQHNAYNKKLSLLFDICRGCSKLSSSDPVLCKSNSCKVYYDRAKTENYAKVQAEMLT 1472

  Fly  1086 R-FGLAEW 1092
            : .|..:|
pombe  1473 KTLGSLDW 1480

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PolD1	NP_524099.2	PTZ00166	48..1092	CDD:240301	316/1501 (21%)
rev3	NP_594068.1	PTZ00166	36..>210	CDD:240301	44/178 (25%)
		DNA_polB_zeta_exo	648..873	CDD:99821	40/245 (16%)
		POLBc_zeta	899..1344	CDD:99917	156/457 (34%)
		zf-C4pol	1381..1457	CDD:464119	18/77 (23%)