Protein Alignment PolD1 and pole-1

DIOPT Version :10

• Sequence 1: NP_524099.2
• Gene: PolD1 / 39746
• FlyBaseID: FBgn0263600
• Length: 1092
• Species: Drosophila melanogaster
• Sequence 2: NP_493616.1
• Gene: pole-1 / 173368
• WormBaseID: WBGene00009368
• Length: 2144
• Species: Caenorhabditis elegans
• Alignment Length: 1167
• Identity: 222/1167 - (19%)
• Similarity: 385/1167 - (32%)
• Gaps: 443/1167 - (37%)

  Fly   124 FCPYFYIEAPSQFE-----------------EH----------HCEKLQKA-------------- 147
            |.|||||.....||                 ||          |...|:|.
 Worm    88 FRPYFYIATLDGFEFQVSSYLSKKYGAQTAVEHMDREDLDLKDHLSGLKKTYIKLSFTSTVELIK 152

  Fly   148 LDQKVIADIRNNKDNVQEAVLMVELVEKLNIHGYNGDKKQRYIKISVTLPRFVAAASRLLKKEVI 212
            :.::::..:|.|.|.:::.....:.:.: |:.|..||.|.:.                 |..:::
 Worm   153 IRKELMPLVRKNTDRIKKESAYADYLAR-NLSGKGGDSKDQQ-----------------LNGDIL 199

  Fly   213 MSEIDFQDCRAFENNIDFDIRFMVDTDVVGCNWIELP-MGHWRIRNSHSKPLPESRCQIEVDVAF 276
            ...:|.:     |.::.|.:|..:|..:....|.::. :|..|:.....|.||
 Worm   200 NQIVDIR-----EYDVPFHMRVSIDEKIFVGLWYDVKGIGPNRVPTIKRKDLP------------ 247

  Fly   277 DRFISHEPEGEWSKVAPFRILSFDIECAGRKGIFPEAKIDPVIQIANMVIRQG----EREPFIR- 336
               :.|         |..::|:||||.......||:.:.|.::.|:.||..:|    .||....
 Worm   248 ---LFH---------AKPKVLAFDIETTKLPLKFPDRESDEIMMISYMVDGRGFLIINREIVSAD 300

  Fly   337 -NVFTLNECAPIIGSQVLCHDK-ETQMLDKWSAFVREVDPDILTGYNINNFDFPYLLNRAAHLKV 399
             |.|.....|..||...:.::| |..::.|:.....:|.|:|:..||.:.||:|::..||   |:
 Worm   301 INAFEYTPKAEYIGEFTVWNEKDEAALIRKFFDHFLQVRPNIVVTYNGDFFDWPFVEARA---KI 362

  Fly   400 RNF--------------EYLGR--------------------IKNIRSVIKEQMLQSKQMGRREN 430
            |.|              ||..|                    .:|:::|.|.::
 Worm   363 RGFNMEREIGFSKDSADEYKSRNCIHMDAFRWVKRDSYLPVGSQNLKAVTKAKL----------- 416

  Fly   431 QYVNFEGRVPFDLLFVLLRD--YKLRSYTL-NAVSYHFLQEQ----------------KEDV--- 473
            :|...|  |..:|:..:.|:  .:|.:|:: :|||.::|..:                .:||
 Worm   417 RYDPVE--VEPELMCKMAREQPQQLANYSVSDAVSTYYLYMKYVHQFIFALCTIIPLGADDVLRK 479

  Fly   474 ---------------HHSII-TDLQNGDEQTRRRLAMYCLKDAYLPLRLLEKLMAIVNYMEMARV 522
                           |::|: .:...|.|:||      ..||.:    .:|....:..::|....
 Worm   480 GSGTLCEALLMVEAFHNNIVFPNKYTGPEETR------FSKDGH----RVESETYVGGHVEALEA 534

  Fly   523 ----TGVPLESLLTRGQQIKVLSQL-------LRKAKTKGFIMPSYTSQGSDEQ-------YEG- 568
                ..:|.:..|:    :..|.||       |||...:.|.:........|||       ::|
 Worm   535 GVFRADIPAKFRLS----VPALEQLKSEIQETLRKELAREFEVTLDQVVDFDEQCAEVQDAFDGM 595

  Fly   569 ---ATVIEPKRGYYADPISTLDFASLYPSIMMAHNL----------------------CYTTL-- 606
               .|.:|..|.|:      ||..::||:|::.:.|                      |..|:
 Worm   596 INVPTRLENPRIYH------LDVGAMYPNIILTNRLQPCAMVTEEICMGCSYNKPDAECKRTMAW 654

  Fly   607 --------VLGGTREKLRQQ----------------ENLQDDQVE---------RTPANNYFVKS 638
                    ...|..:::.||                |..:.:.:|         |.....:..:.
 Worm   655 EWRGELTPATRGEYQQIMQQLEAESFGKPPKHFHMLERSEREAIEMKRIKDYSRRVYGKTHLTRL 719

  Fly   639 EVRRGLLPE-----ILESLLAARKR-------------------AKNDLKVETDPFKRKVL-DGR 678
            |:|...:.:     .:|::.|.|.|                   |.|||...|......|| :..
 Worm   720 EMRETTICQRENHFYVETVKAFRDRRYEYKDMLKKAKGRFDQAQATNDLATMTTSKLEMVLYESL 784

  Fly   679 QLALKISANSVYGFTGAQVGKLPCLEISGSVTAYGRTMIEMTKNEVESHYTQANGYENNAVVIYG 743
            |||.|...||.||:...:..:...:|::|.|...|..:|...:..||...|.          :..
 Worm   785 QLAHKCILNSFYGYVMRKGSRWFSMEMAGIVCHTGANIIREARKLVEQIGTP----------LEL 839

  Fly   744 DTDSVM----------VNFGVKTLERSMEL----GREAAELVSSKFVHPIKLEFEK--------- 785
            |||.:.          |.|.:|..:||...    |.....||...|.:......||
 Worm   840 DTDGIWCLIPASFPENVTFKLKNHKRSSVTVSYPGAMLNALVYEGFTNHQYHTLEKDGSYSKSSE 904

  Fly   786 --VYY----PYLLI-----------NKKRYAGLYFTRPDTYDKMDCKGIETVRRDNSPLVANLMN 833
              :|:    ||..:           .|||||  .|....:..:|  ||.|..||....::.: ..
 Worm   905 NSIYFEVDGPYQCMILPASKEEGKKLKKRYA--VFNLDGSLAEM--KGFELKRRGELNIIKH-FQ 964

  Fly   834 SCLQKLLIERDPDGAV---AYVKQVIADLLCNRIDISHL------------VITKELAKT----D 879
            .|:.|..:    :|..   .| |.|.|| ..:.:||.|.            :|::..:.:    |
 Worm   965 GCVFKTFL----NGKTLEETY-KAVAAD-ADHWLDILHSHGADLTDEELFDLISENRSMSRKLED 1023

  Fly   880 YAA-KQAHVELAAKMKK-------RDPGTAPKLGDRVPYVICAAAKNTPAYQKAEDPLYVLENSV 936
            |.| |...:..|.::.:       :|.|.|      ..::|.......|..::| .|:.:.::..
 Worm  1024 YGAQKSTSISTAKRLAEFLGDDMVKDAGLA------CMFIISKHPIGAPVTERA-IPVAIFKSDA 1081

  Fly   937 PI------------------------DATYYLE----------------QQLSKPLLRIFEP 958
            .:                        |..||||                |.:|.|:.|:..|
 Worm  1082 KVRSHYIRKWTKQVDFNEDTDIRDMLDWDYYLERFGSCIQKIITIPAALQGISNPVPRVPHP 1143

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PolD1	NP_524099.2	PTZ00166	48..1092	CDD:240301	222/1167 (19%)
pole-1	NP_493616.1	DNA_polB_epsilon_exo	253..455	CDD:99822	52/217 (24%)
		POLBc_epsilon	516..1132	CDD:99918	120/657 (18%)
		DUF1744	1468..1869	CDD:462493