Protein Alignment CG7579 and GALNT18

DIOPT Version :10

• Sequence 1: NP_648799.1
• Gene: CG7579 / 39714
• FlyBaseID: FBgn0036528
• Length: 498
• Species: Drosophila melanogaster
• Sequence 2: NP_940918.2
• Gene: GALNT18 / 374378
• HGNCID: 30488
• Length: 607
• Species: Homo sapiens
• Alignment Length: 514
• Identity: 155/514 - (30%)
• Similarity: 248/514 - (48%)
• Gaps: 72/514 - (14%)

  Fly    12 QNEKYQYNAWLSERIPLKRTLEDYRDPQCLKINYSSEKTVTVSIVIAIQQEHPHTLLRGIYSVIT 76
            |.:.|.|||:||:|:||.|.|.|.|...|..::: .:....||||.....|....|||.|:|.:.
Human   116 QFQYYGYNAYLSDRLPLDRPLPDLRPSGCRNLSF-PDSLPEVSIVFIFVNEALSVLLRSIHSAME 179

  Fly    77 QTSPYLLKEIVLVHDGHPDLDL-------IRHIHHKLPIVIQLEMES-SKGIIHARLTGAGVATG 133
            :|.|:|||||:||.|...:.:|       :..::.:.|..|::...| .:|:|.:|::|...||.
Human   180 RTPPHLLKEIILVDDNSSNEELKEKLTEYVDKVNSQKPGFIKVVRHSKQEGLIRSRVSGWRAATA 244

  Fly   134 DILVFLNGHMEVTRGWLPPLLEPILLNNQTVTEPIVDAISRESFAYRKLVEPEQLA---FDWQLD 195
            .::...:.|:|...||..|:|..|..|.:.:..|..|.|..::|.    :|...||   |||:|.
Human   245 PVVALFDAHVEFNVGWAEPVLTRIKENRKRIISPSFDNIKYDNFE----IEEYPLAAQGFDWELW 305

  Fly   196 HIFLPLDQHSW---NSLPKPYPSSQLEGRVFAIDRKWFWHLGGWDEGLRDYGGDALELSLKVWQC 257
            ..:|...:..|   || ..|..|..|.| .|.:||::|..:|..|||:..|||:.:||.::||||
Human   306 CRYLNPPKAWWKLENS-TAPIRSPALIG-CFIVDRQYFQEIGLLDEGMEVYGGENVELGIRVWQC 368

  Fly   258 GGLILAVPCSRVGIIYKRDELEAQMAPNRNPSLQVQKNFKRVVDVWLDEYKLHFY-RYN-PK--- 317
            ||.:..:||||:..|.:     |......:.:..|::|..||.:||:||:|.|.| .:| |:
Human   369 GGSVEVLPCSRIAHIER-----AHKPYTEDLTAHVRRNALRVAEVWMDEFKSHVYMAWNIPQEDS 428

  Fly   318 ---LRNLTAESLDKPRDLRRRLNCKSFEWYRSQVAPQIRNHFLHAGLTNYPIGKIMPFVAPHFCL 379
               :.::||.     :.||::|.||:|.||...|.|::|   :::.:..|  |.:...:....||
Human   429 GIDIGDITAR-----KALRKQLQCKTFRWYLVSVYPEMR---MYSDIIAY--GVLQNSLKTDLCL 483

  Fly   380 SIKG----GFPVIRKCHSTNFEDWTLTSRCQLKHG----------NMCLDVDYKNNVRATKCT-K 429
            . :|    ..|::..||....::...||..|:..|          |.|| ||..:..|..:|: .
Human   484 D-QGPDTENVPIMYICHGMTPQNVYYTSSQQIHVGILSPTVDDDDNRCL-VDVNSRPRLIECSYA 546

  Fly   430 KLSKNPWHYNYQHSSFVSN--GNKCLQIDVNK-----VGLILSACDSDVTEQRWMFTKV 481
            |..:...|:.:.....:.|  ..:||::..|.     ..|:|..|..    |.|..|.|
Human   547 KAKRMKLHWQFSQGGPIQNRKSKRCLELQENSDLEFGFQLVLQKCSG----QHWSITNV 601

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG7579	NP_648799.1	pp-GalNAc-T	54..349	CDD:133004	104/316 (33%)
		beta-trefoil_Ricin_Pgant8-like	364..479	CDD:467339	30/136 (22%)
GALNT18	NP_940918.2	Catalytic subdomain A	153..267		36/113 (32%)
		pp-GalNAc-T	157..458	CDD:133004	104/316 (33%)
		Catalytic subdomain B	324..385		28/61 (46%)
		beta-trefoil_Ricin_GALNT18	461..602	CDD:467353	33/152 (22%)