DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AGO2 and AGO2

DIOPT Version :9

Sequence 1:	NP_730054.1	Gene:	AGO2 / 39683	FlyBaseID:	FBgn0087035	Length:	1217	Species:	Drosophila melanogaster
Sequence 2:	NP_174413.2	Gene:	AGO2 / 840016	AraportID:	AT1G31280	Length:	1014	Species:	Arabidopsis thaliana

Alignment Length:	1054	Identity:	300/1054 - (28%)
Similarity:	463/1054 - (43%)	Gaps:	183/1054 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   247 QEGGYQQRPPGQQQGGHQQGRQGQEG-GYQQRPPGQQQGGHEQGR-QGQEGGYQQRPSGQQQGGH 309
            :.|||        :||...|| |:.| ||     |...||.|||| :|..||.|.|..|.::||
plant     2 ERGGY--------RGGRGDGR-GRGGRGY-----GGGGGGGEQGRDRGYGGGEQGRGRGSERGG- 51

  Fly   310 QQGRQGQEGGYQQRPSGQQQGGHQQGRQGQEGGYQQRPSGQ----------QQGGHQQGRQGQEG 364
              |.:||..|.||....|.|.|...|..|:.....|:|..|          ...|...|..|: |
plant    52 --GNRGQGRGEQQDFRSQSQRGPPPGHGGRGTTQFQQPRPQVAPQPSQAPASYAGSVGGVAGR-G 113

  Fly   365 GYQQRPPGQQPNQTQSQGQYQSRGPPQQQQAAPLPLPP--QPAGSIKRGTIGKPGQVG------- 420
            .:.::|  |.|:.:.|.....:......:.|..:.|.|  |.|.|.::..:.:|.:.|
plant   114 AWGRKP--QVPSDSASPSTSTTVVSEPVRVAEVMNLKPSVQVATSDRKEPMKRPDRGGVVAVRRV 176

  Fly   421 ---INYLDLDLSKMPSVAYHYDVKIMPERP-KKFYRQAFEQFRV---------DQLGGAVLAYDG 472
               :|:..::.:. .||..||||:|..|.| ||..|  ||...|         |:...|:.||||
plant   177 NLYVNHYKVNFNP-ESVIRHYDVEIKGEIPTKKVSR--FELAMVRDKVFTDNPDEFPLAMTAYDG 238

  Fly   473 KASCYSVDKLPLNSQNPEVTVTDR-NGRTLRYTIEIKETGDSTIDLKSLTTYMNDRIFDKPMRAM 536
            :.:.:|..:||..|...|...|:. .||:  ||..||:.  :.:.|..|..||..|....|...:
plant   239 QKNIFSAVELPTGSYKVEYPKTEEMRGRS--YTFTIKQV--NVLKLGDLKEYMTGRSSFNPRDVL 299

  Fly   537 QCVEVVLASPCHNKAIRVGRSFF-KMSDPNN------------RHELDDGYEALVGLYQAFMLGD 588
            |.::||:........|.||:||| :.::|:.            ||.|....:.|
plant   300 QGMDVVMKEHPSKCMITVGKSFFTRETEPDEDFRFGVIAAKGYRHTLKPTAQGL----------- 353

  Fly   589 RPFLNVDISHKSFPISMPMIEYLERFSLKAKINNTTNLDYSRRFLEPFLRGINVVYTPPQSFQSA 653
              .|.:|.|..:|..:|.:|||     ||...|.:....:.||.:|..|.|:.|.....::.|..
plant   354 --SLCLDYSVLAFRKAMSVIEY-----LKLYFNWSDMRQFRRRDVEEELIGLKVTVNHRKNKQKL 411

  Fly   654 PRVYRVNGLSRAPASSETF---EHDG----KKVTIASYF---HSRNYPLKFPQLHCLNVGSSIKS 708
            ..|    |||........|   :.:|    :|.:|..||   :.|:...|  .:.||::|.:.:.
plant   412 TIV----GLSMQNTKDIKFDLIDQEGNEPPRKTSIVEYFRIKYGRHIVHK--DIPCLDLGKNGRQ 470

  Fly   709 ILLPIELCSIEEGQALNRKDGATQVANMIKYAATSTNVRKRKIMNLLQYFQHNLD--------PT 765
            ..:|:|.|.:.||| :..||      |:.|.:|..  ::|..::| .|..|.|:|        |:
plant   471 NFVPMEFCDLVEGQ-IYPKD------NLDKDSALW--LKKLSLVN-PQQRQRNIDKMIKARNGPS 525

  Fly   766 ----ISRFGIRIANDFIVVSTRVLSPPQVEYHSKRFTMVKNGSWRMDGMKFLEPKPKAHK----- 821
                |..||:::..:...|..|||..|.::. ::|..:|:.           ||.|:.:.
plant   526 GGEIIGNFGLKVDTNMTPVEGRVLKAPSLKL-AERGRVVRE-----------EPNPRQNNQWNLM 578

  Fly   822 ------------CAVLYCDPRSGRKMNYTQLNDFGNLIISQGKAVNISLDSDVTYRPFTDDERSL 874
                        .|||  |..:..:.| ...|||.:.:|.:...:.:.:::.:.|:....:..|.
plant   579 KKGVTRGSIVKHWAVL--DFTASERFN-KMPNDFVDNLIDRCWRLGMQMEAPIVYKTSRMETLSN 640

  Fly   875 DTIFADLKRSQHDLA----------IVIIPQFR--ISYDTIKQKAELQHGILTQCIKQFTVERKC 927
            .....:|.||..|.|          :|:....|  ..|.|:|..||.:.|::|||...... .|.
plant   641 GNAIEELLRSVIDEASRKHGGARPTLVLCAMSRKDDGYKTLKWIAETKLGLVTQCFLTGPA-TKG 704

  Fly   928 NNQTIGNILLKINSKLNGINHKIKDDPRLPMMK---NTMYIGADVTHPSPDQREIPSVVGVAASH 989
            .:|...|:.||:|:|:.|.|.::.|  .....|   ..|:|||||.||:...:..||:|.|..:.
plant   705 GDQYRANLALKMNAKVGGSNVELMD--TFSFFKKEDEVMFIGADVNHPAARDKMSPSIVAVVGTL 767

  Fly   990 D-PYGASYNMQYRLQRGALEEIEDMFSITLEHLRVYKEYRNAYPDHIIYYRDGVSDGQFPKIKNE 1053
            : |....|..:...|....|||:......||.::.:.:.....|:.|:.:||||||.||..:.|.
plant   768 NWPEANRYAARVIAQPHRKEEIQGFGDACLELVKAHVQATGKRPNKIVIFRDGVSDAQFDMVLNV 832

  Fly  1054 ELRCIKQACDKVGCKPKICCVIVVKRHHTRFFPSGDVTTSNKFNNVDPGTVVDRTIVHPNEMQFF 1118
            ||..:|...:|.|..|||..::..|||.|||||:.:...|:| .||..|||||..::||.|..|:
plant   833 ELLDVKLTFEKNGYNPKITVIVAQKRHQTRFFPATNNDGSDK-GNVPSGTVVDTKVIHPYEYDFY 896

  Fly  1119 MVSHQAIQGTAKPTRYNVIENTGNLDIDLLQQLTYNLCHMFPRCNRSVSYPAPAYLAHLVAARGR 1183
            :.||....||:|||.|..:.:......|.:|:|.:.:|..|.||.:.||...|.|.|.:||.|||
plant   897 LCSHHGGIGTSKPTHYYTLWDELGFTSDQVQKLIFEMCFTFTRCTKPVSLVPPVYYADMVAFRGR 961

  Fly  1184 VYLTGTNRFLDLKK 1197
            :|...::|..:.|:
plant   962 MYHEASSREKNFKQ 975

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AGO2	NP_730054.1	PLN03202	411..1180	CDD:215631	239/857 (28%)
		ArgoN	411..543	CDD:293095	44/152 (29%)
		ArgoL1	554..601	CDD:285861	13/59 (22%)
		PAZ	605..719	CDD:239207	32/123 (26%)
		Piwi_ago-like	764..1186	CDD:240015	137/458 (30%)
AGO2	NP_174413.2	PLN03202	137..957	CDD:215631	252/907 (28%)
		ArgoN	164..306	CDD:293095	45/162 (28%)
		ArgoL1	317..366	CDD:285861	12/60 (20%)
		PAZ	383..488	CDD:280352	30/114 (26%)
		Piwi_ago-like	528..963	CDD:240015	136/458 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1041
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D159407at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22891
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	6	5.880