Protein Alignment AGO2 and ago1

DIOPT Version :10

• Sequence 1: NP_730054.1
• Gene: AGO2 / 39683
• FlyBaseID: FBgn0087035
• Length: 1217
• Species: Drosophila melanogaster
• Sequence 2: NP_587782.1
• Gene: ago1 / 2539403
• PomBaseID: SPCC736.11
• Length: 834
• Species: Schizosaccharomyces pombe
• Alignment Length: 853
• Identity: 231/853 - (27%)
• Similarity: 389/853 - (45%)
• Gaps: 106/853 - (12%)

  Fly   411 GTIGKPGQVGINYLDLDLSKMPSVA---YHYDVKIMPERPKKFYRQAFEQFRVDQLGGAV---LA 469
            |.:||...:..|:  ..:..:|:..   ||..|......|:|..:..:....|.|..|:.   ..
pombe    16 GGLGKQITLKANF--FQIISLPNETINQYHVIVGDGSRVPRKQSQLIWNSKEVKQYFGSSWMNSV 78

  Fly   470 YDGKASCYSVDKLPLNSQNPEVTV-TDRNGRTLRYTIEIKETGDSTIDLKSLTTYMNDRIFDKP- 532
            |||::.|:|  |..:.....:|.: ::.:.|.:.::|:    ..|.|:|.:|:.::|.:....|
pombe    79 YDGRSMCWS--KGDIADGTIKVNIGSESHPREIEFSIQ----KSSKINLHTLSQFVNSKYSSDPQ 137

  Fly   533 -MRAMQCVEVVLASPCHNKAIRVGRSFFKMSDPNNRHELDDGYEALVGLYQAFMLGDRP-----F 591
             :.::..::::|.............|||   ...|...|..|.||..|.||:.    ||     .
pombe   138 VLSSIMFLDLLLKKKPSETLFGFMHSFF---TGENGVSLGGGVEAWKGFYQSI----RPNQGFMS 195

  Fly   592 LNVDISHKSFPISMPMIEYLERFSLKAKINNTTNLDYSR-----RFLEPFLRGINVVYTPPQSFQ 651
            :|||||..:|..:..:::.|..::..:.:.:.|..|..|     |||:...:..|.|.|     .
pombe   196 VNVDISSSAFWRNDSLLQILMEYTDCSNVRDLTRFDLKRLSRKFRFLKVTCQHRNNVGT-----D 255

  Fly   652 SAPRVYRVNGLSRAPASSETF----EHDGKKVTIASYF-HSRNYPLKFPQLHCLNVGSSIKSILL 711
            .|.|||.:.|.|...||...|    ..:.:|:::|.|| .:.|..|::|.|.|:.|.:   ..:|
pombe   256 LANRVYSIEGFSSKSASDSFFVRRLNGEEQKISVAEYFLENHNVRLQYPNLPCILVKN---GAML 317

  Fly   712 PIELCSIEEGQALNRKDGATQVANMIKYAATSTNVRKRKIMNLLQYFQHNLDPTISRFGIRIAND 776
            |||.|.:.:||....|..:.|.||||::|......|.::|.:.:.....:.||.::::|::|...
pombe   318 PIEFCFVVKGQRYTAKLNSDQTANMIRFAVQRPFERVQQIDDFVHQMDWDTDPYLTQYGMKIQKK 382

  Fly   777 FIVVSTRVLSPPQVEYHSKRFTMVKNGSWRMDGMKFLEPKPKA--HKCAVLYCDPRSGRKMNYTQ 839
            .:.|..|||..|.:.|.........:|.|.:.|.:||:| |:|  ...||: |. .|.|::....
pombe   383 MLEVPARVLETPSIRYGGDCIERPVSGRWNLRGKRFLDP-PRAPIRSWAVM-CF-TSTRRLPMRG 444

  Fly   840 LNDFGNLIISQGKAVNISLDSDVTYRPFTDDERSLDTIFADLKRSQHDLAIVII----------P 894
            :.:|....:....::.|:.   |..:|        ..::||::.|..:|.|.:.          |
pombe   445 IENFLQTYVQTLTSLGINF---VMKKP--------PVLYADIRGSVEELCITLYKKAEQVGNAPP 498

  Fly   895 QFRI---------SYDTIKQKAELQHGILTQC-IKQFTVERKCNNQTIGNILLKINSKLNGINHK 949
            .:..         .|.:||:......|:.:|| |.:..::.|  .|...|:.:|||.|:.|||..
pombe   499 DYLFFILDKNSPEPYGSIKRVCNTMLGVPSQCAISKHILQSK--PQYCANLGMKINVKVGGINCS 561

  Fly   950 I--KDDP--RLPMMKNTMYIGADVTHPSPDQREIPSVVGVAASHDPYGASYNMQYRLQRGALEEI 1010
            :  |.:|  .:|    |:.:|.||.||......: |:..:.||.|..|..|....|.|....|.|
pombe   562 LIPKSNPLGNVP----TLILGGDVYHPGVGATGV-SIASIVASVDLNGCKYTAVSRSQPRHQEVI 621

  Fly  1011 EDMFSITLEHLRVYKEYRNAYPDHIIYYRDGVSDGQFPKIKNEELRCIKQACDKVGCK--PKICC 1073
            |.|..|.:..|:.::......|..|||:|||.|:|||..:.|:||..||:||..:..|  |||..
pombe   622 EGMKDIVVYLLQGFRAMTKQQPQRIIYFRDGTSEGQFLSVINDELSQIKEACHSLSPKYNPKILV 686

  Fly  1074 VIVVKRHHTRFF----PSGDVTTSNKFNNVDPGTVVDRTIVHPNEMQFFMVSHQAIQGTAKPTRY 1134
            ....||||.|||    ..||     :..|..|||::::.:.||.:..|:::||.::||.:.|..|
pombe   687 CTTQKRHHARFFIKNKSDGD-----RNGNPLPGTIIEKHVTHPYQYDFYLISHPSLQGVSVPVHY 746

  Fly  1135 NVIENTGNLDIDLLQQLTYNLCHMFPRCNRSVSYPAPAYLAHLVAARGRVY-LTGTNRFLDLKKE 1198
            .|:.:...:..|..|.|.||||:::.|...:||...|.|.||||:...|.. :|..:.|::..:.
pombe   747 TVLHDEIQMPPDQFQTLCYNLCYVYARATSAVSLVPPVYYAHLVSNLARYQDVTADDTFVETSEA 811

  Fly  1199 YAKRTIVP 1206
            ...:.:.|
pombe   812 SMDQEVKP 819

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AGO2	NP_730054.1	ArgoN	471..543	CDD:465134	14/74 (19%)
		ArgoL1	554..601	CDD:462567	18/51 (35%)
		PAZ	605..719	CDD:239207	34/123 (28%)
		Piwi_ago-like	764..1186	CDD:240015	134/454 (30%)
ago1	NP_587782.1	ArgoN	20..149	CDD:465134	26/136 (19%)
		ArgoL1	163..207	CDD:462567	19/50 (38%)
		PAZ_argonaute_like	210..325	CDD:239212	34/122 (28%)
		Piwi_ago-like	370..796	CDD:240015	133/451 (29%)