DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AGO2 and ago1

DIOPT Version :9

Sequence 1:	NP_730054.1	Gene:	AGO2 / 39683	FlyBaseID:	FBgn0087035	Length:	1217	Species:	Drosophila melanogaster
Sequence 2:	NP_587782.1	Gene:	ago1 / 2539403	PomBaseID:	SPCC736.11	Length:	834	Species:	Schizosaccharomyces pombe

Alignment Length:	853	Identity:	231/853 - (27%)
Similarity:	389/853 - (45%)	Gaps:	106/853 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   411 GTIGKPGQVGINYLDLDLSKMPSVA---YHYDVKIMPERPKKFYRQAFEQFRVDQLGGAV---LA 469
            |.:||...:..|:  ..:..:|:..   ||..|......|:|..:..:....|.|..|:.   ..
pombe    16 GGLGKQITLKANF--FQIISLPNETINQYHVIVGDGSRVPRKQSQLIWNSKEVKQYFGSSWMNSV 78

  Fly   470 YDGKASCYSVDKLPLNSQNPEVTV-TDRNGRTLRYTIEIKETGDSTIDLKSLTTYMNDRIFDKP- 532
            |||::.|:|  |..:.....:|.: ::.:.|.:.::|:    ..|.|:|.:|:.::|.:....|
pombe    79 YDGRSMCWS--KGDIADGTIKVNIGSESHPREIEFSIQ----KSSKINLHTLSQFVNSKYSSDPQ 137

  Fly   533 -MRAMQCVEVVLASPCHNKAIRVGRSFFKMSDPNNRHELDDGYEALVGLYQAFMLGDRP-----F 591
             :.::..::::|.............|||   ...|...|..|.||..|.||:.    ||     .
pombe   138 VLSSIMFLDLLLKKKPSETLFGFMHSFF---TGENGVSLGGGVEAWKGFYQSI----RPNQGFMS 195

  Fly   592 LNVDISHKSFPISMPMIEYLERFSLKAKINNTTNLDYSR-----RFLEPFLRGINVVYTPPQSFQ 651
            :|||||..:|..:..:::.|..::..:.:.:.|..|..|     |||:...:..|.|.|     .
pombe   196 VNVDISSSAFWRNDSLLQILMEYTDCSNVRDLTRFDLKRLSRKFRFLKVTCQHRNNVGT-----D 255

  Fly   652 SAPRVYRVNGLSRAPASSETF----EHDGKKVTIASYF-HSRNYPLKFPQLHCLNVGSSIKSILL 711
            .|.|||.:.|.|...||...|    ..:.:|:::|.|| .:.|..|::|.|.|:.|.:   ..:|
pombe   256 LANRVYSIEGFSSKSASDSFFVRRLNGEEQKISVAEYFLENHNVRLQYPNLPCILVKN---GAML 317

  Fly   712 PIELCSIEEGQALNRKDGATQVANMIKYAATSTNVRKRKIMNLLQYFQHNLDPTISRFGIRIAND 776
            |||.|.:.:||....|..:.|.||||::|......|.::|.:.:.....:.||.::::|::|...
pombe   318 PIEFCFVVKGQRYTAKLNSDQTANMIRFAVQRPFERVQQIDDFVHQMDWDTDPYLTQYGMKIQKK 382

  Fly   777 FIVVSTRVLSPPQVEYHSKRFTMVKNGSWRMDGMKFLEPKPKA--HKCAVLYCDPRSGRKMNYTQ 839
            .:.|..|||..|.:.|.........:|.|.:.|.:||:| |:|  ...||: |. .|.|::....
pombe   383 MLEVPARVLETPSIRYGGDCIERPVSGRWNLRGKRFLDP-PRAPIRSWAVM-CF-TSTRRLPMRG 444

  Fly   840 LNDFGNLIISQGKAVNISLDSDVTYRPFTDDERSLDTIFADLKRSQHDLAIVII----------P 894
            :.:|....:....::.|:.   |..:|        ..::||::.|..:|.|.:.          |
pombe   445 IENFLQTYVQTLTSLGINF---VMKKP--------PVLYADIRGSVEELCITLYKKAEQVGNAPP 498

  Fly   895 QFRI---------SYDTIKQKAELQHGILTQC-IKQFTVERKCNNQTIGNILLKINSKLNGINHK 949
            .:..         .|.:||:......|:.:|| |.:..::.|  .|...|:.:|||.|:.|||..
pombe   499 DYLFFILDKNSPEPYGSIKRVCNTMLGVPSQCAISKHILQSK--PQYCANLGMKINVKVGGINCS 561

  Fly   950 I--KDDP--RLPMMKNTMYIGADVTHPSPDQREIPSVVGVAASHDPYGASYNMQYRLQRGALEEI 1010
            :  |.:|  .:|    |:.:|.||.||......: |:..:.||.|..|..|....|.|....|.|
pombe   562 LIPKSNPLGNVP----TLILGGDVYHPGVGATGV-SIASIVASVDLNGCKYTAVSRSQPRHQEVI 621

  Fly  1011 EDMFSITLEHLRVYKEYRNAYPDHIIYYRDGVSDGQFPKIKNEELRCIKQACDKVGCK--PKICC 1073
            |.|..|.:..|:.::......|..|||:|||.|:|||..:.|:||..||:||..:..|  |||..
pombe   622 EGMKDIVVYLLQGFRAMTKQQPQRIIYFRDGTSEGQFLSVINDELSQIKEACHSLSPKYNPKILV 686

  Fly  1074 VIVVKRHHTRFF----PSGDVTTSNKFNNVDPGTVVDRTIVHPNEMQFFMVSHQAIQGTAKPTRY 1134
            ....||||.|||    ..||     :..|..|||::::.:.||.:..|:::||.::||.:.|..|
pombe   687 CTTQKRHHARFFIKNKSDGD-----RNGNPLPGTIIEKHVTHPYQYDFYLISHPSLQGVSVPVHY 746

  Fly  1135 NVIENTGNLDIDLLQQLTYNLCHMFPRCNRSVSYPAPAYLAHLVAARGRVY-LTGTNRFLDLKKE 1198
            .|:.:...:..|..|.|.||||:::.|...:||...|.|.||||:...|.. :|..:.|::..:.
pombe   747 TVLHDEIQMPPDQFQTLCYNLCYVYARATSAVSLVPPVYYAHLVSNLARYQDVTADDTFVETSEA 811

  Fly  1199 YAKRTIVP 1206
            ...:.:.|
pombe   812 SMDQEVKP 819

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AGO2	NP_730054.1	PLN03202	411..1180	CDD:215631	227/824 (28%)
		ArgoN	411..543	CDD:293095	28/140 (20%)
		ArgoL1	554..601	CDD:285861	18/51 (35%)
		PAZ	605..719	CDD:239207	34/123 (28%)
		Piwi_ago-like	764..1186	CDD:240015	134/454 (30%)
ago1	NP_587782.1	PLN03202	4..833	CDD:215631	231/853 (27%)
		ArgoN	12..149	CDD:293095	28/140 (20%)
		ArgoL1	163..207	CDD:285861	19/50 (38%)
		PAZ_argonaute_like	210..325	CDD:239212	34/122 (28%)
		Piwi_ago-like	370..796	CDD:240015	133/451 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1041
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG58336
OrthoFinder	1	1.000	-	-		FOG0000468
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22891
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.920