Protein Alignment AGO2 and rde-1

DIOPT Version :10

• Sequence 1: NP_730054.1
• Gene: AGO2 / 39683
• FlyBaseID: FBgn0087035
• Length: 1217
• Species: Drosophila melanogaster
• Sequence 2: NP_741611.1
• Gene: rde-1 / 179393
• WormBaseID: WBGene00004323
• Length: 1020
• Species: Caenorhabditis elegans
• Alignment Length: 1049
• Identity: 221/1049 - (21%)
• Similarity: 382/1049 - (36%)
• Gaps: 258/1049 - (24%)

  Fly   381 QGQYQSRGPPQQQQAAPLPLPPQPAGSIKRGTIGKPGQVGINYLDLDLSKMPSVAYHYDVKI--- 442
            :|.|:....|:.:..|      :|.|........|...:.:|:............|.|:||:
 Worm    10 KGFYRHSLDPEMKWLA------RPTGKCDGKFYEKKVLLLVNWFKFSSKIYDREYYEYEVKMTKE 68

  Fly   443 -----------------MPERPKKFYRQAFEQFRVDQLGGAVLAYDGKASCYSVDKLPLNSQNPE 490
                             :|:|.|.|::....:.:..........:|.|.:.|||.:  ||:...:
 Worm    69 VLNRKPGKPFPKKTEIPIPDRAKLFWQHLRHEKKQTDFILEDYVFDEKDTVYSVCR--LNTVTSK 131

  Fly   491 VTVTDRNGRTLRYTIEIKETGDSTIDLKSLTTYM--------------NDRIFDKPMRAMQCVEV 541
            :.|::   :.::...|.|:..|  ::.|.|.|.:              |....::..|:.:.::.
 Worm   132 MLVSE---KVVKKDSEKKDEKD--LEKKILYTMILTYRKKFHLNFSRENPEKDEEANRSYKFLKN 191

  Fly   542 VLASPC---------------------HNKAIRVGRSFFKMSDPNNRH---ELDDGYEALVGLYQ 582
            |:....                     :|..:||..||   .|||...   |:....||..|:|.
 Worm   192 VMTQKVRYAPFVNEEIKVQFAKNFVYDNNSILRVPESF---HDPNRFEQSLEVAPRIEAWFGIYI 253

  Fly   583 AF--MLGDRPFLNVDISHKSF---PISMPMIEYL------------ERFSLKAKI--NNTTNLDY 628
            ..  :....|.||..|..|.|   | .|.:::||            .|..||.|:  ...|....
 Worm   254 GIKELFDGEPVLNFAIVDKLFYNAP-KMSLLDYLLLIVDPQSCNDDVRKDLKTKLMAGKMTIRQA 317

  Fly   629 SRRFLEPFLRGINV----VYTPPQS------------FQSAPRVYRVNGLSRAPASSETFEHDGK 677
            :|..:...|..:.:    |:....|            .:....||:|.|.|....:::.::
 Worm   318 ARPRIRQLLENLKLKCAEVWDNEMSRLTERHLTFLDLCEENSLVYKVTGKSDRGRNAKKYD---- 378

  Fly   678 KVTIASYFHSRNYPLKFPQLHCLNVGSSIKSILLPIELCSIEE--GQALNRKDGATQVANMIKYA 740
             .|:...:......::||.|..:.|.|..|...:|:|...:.|  .:..||.|...| ...:|.|
 Worm   379 -TTLFKIYEENKKFIEFPHLPLVKVKSGAKEYAVPMEHLEVHEKPQRYKNRIDLVMQ-DKFLKRA 441

  Fly   741 ATSTNVRKRKIMNLLQYFQHNLDPT--ISRFGIRIANDFIVVSTRVLSPPQV---EYHSKRFTMV 800
            ....:..|...:.:|:....:.:..  :.|||:......|....:||..|.:   .....:.|.|
 Worm   442 TRKPHDYKENTLKMLKELDFSSEELNFVERFGLCSKLQMIECPGKVLKEPMLVNSVNEQIKMTPV 506

  Fly   801 KNGSWRMDGMKFLEPKPKAHKCAVLYCDPRSGRKMNYTQLNDFGNLIISQGKAVNI--SLDSDVT 863
            ..|...    |.|...|:...|..::.       :|.|.    ||..:.:...|..  .|.....
 Worm   507 IRGFQE----KQLNVVPEKELCCAVFV-------VNETA----GNPCLEENDVVKFYTELIGGCK 556

  Fly   864 YRPF---TDDERSLDTIFADLKRSQHD-----------------------------------LAI 890
            :|..   .::.|...:|..|..::::.                                   |..
 Worm   557 FRGIRIGANENRGAQSIMYDATKNEYAFYKNCTLNTGIGRFEIAATEAKNMFERLPDKEQKVLMF 621

  Fly   891 VIIPQFRI-SYDTIKQKAELQHGILTQCIKQFTVER--------KCNNQTIGNILLKINSKLNGI 946
            :||.:.:: :|..:|...:...|:..|.|...||.:        |.:.:....|.||||:||.||
 Worm   622 IIISKRQLNAYGFVKHYCDHTIGVANQHITSETVTKALASLRHEKGSKRIFYQIALKINAKLGGI 686

  Fly   947 NHKI----------KDDPRLPMMKNTMYIGADVTHPSPDQREIPSVVGVAASHDPYGASYNMQYR 1001
            |.::          ::..|...|..|||:|.|||||:.......|:..|.||.:|.|..|.....
 Worm   687 NQELDWSEIAEISPEEKERRKTMPLTMYVGIDVTHPTSYSGIDYSIAAVVASINPGGTIYRNMIV 751

  Fly  1002 LQ-------------RGALEEIEDMFSITLEHLRVYKEYR-NAYPDHIIYYRDGVSDGQFPKIKN 1052
            .|             |...:.:|..|   ::.||.:.|.. |..|.||:.|||||||.:..::.:
 Worm   752 TQEECRPGERAVAHGRERTDILEAKF---VKLLREFAENNDNRAPAHIVVYRDGVSDSEMLRVSH 813

  Fly  1053 EELRCIKQAC-------DKVGCKPKICCVIVVKRHHTRFF---------------PS-------- 1087
            :|||.:|...       |....:||...:::.|||:||..               |:
 Worm   814 DELRSLKSEVKQFMSERDGEDPEPKYTFIVIQKRHNTRLLRRMEKDKPVVNKDLTPAETDVAVAA 878

  Fly  1088 -----GDVTTSNKFNNVDP--GTVVDRTIVHPNEMQFFMVSHQAIQGTAKPTRYNVIENTGNLDI 1145
                 .|:..|.:...|:|  ||.||:.||...:..||:.||..:.||::|..|.|:.:...:..
 Worm   879 VKQWEEDMKESKETGIVNPSSGTTVDKLIVSKYKFDFFLASHHGVLGTSRPGHYTVMYDDKGMSQ 943

  Fly  1146 DLLQQLTYNLCHMFPRCNRSVSYPAPAYLAHLVAARGR-VYLTGTNRFLDLKKEYAK---RTIVP 1206
            |.:.::||.|..:..||.:.:|.|.|.:.|||...:.: :|.|....::.   :||:   |..:.
 Worm   944 DEVYKMTYGLAFLSARCRKPISLPVPVHYAHLSCEKAKELYRTYKEHYIG---DYAQPRTRHEME 1005

  Fly  1207 EFMKKNPMY 1215
            .|::.|..|
 Worm  1006 HFLQTNVKY 1014

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AGO2	NP_730054.1	ArgoN	471..543	CDD:465134	16/85 (19%)
		ArgoL1	554..601	CDD:462567	16/51 (31%)
		PAZ	605..719	CDD:239207	26/143 (18%)
		Piwi_ago-like	764..1186	CDD:240015	125/537 (23%)
rde-1	NP_741611.1	PAZ_argonaute_like	280..419	CDD:239212	26/143 (18%)
		Piwi_ago-like	467..982	CDD:240015	125/532 (23%)