Protein Alignment AGO2 and alg-4

DIOPT Version :10

• Sequence 1: NP_730054.1
• Gene: AGO2 / 39683
• FlyBaseID: FBgn0087035
• Length: 1217
• Species: Drosophila melanogaster
• Sequence 2: NP_499191.1
• Gene: alg-4 / 176400
• WormBaseID: WBGene00006449
• Length: 1040
• Species: Caenorhabditis elegans
• Alignment Length: 1055
• Identity: 266/1055 - (25%)
• Similarity: 428/1055 - (40%)
• Gaps: 253/1055 - (23%)

  Fly   369 RPPGQQPNQTQSQGQYQSRGPPQ--------------QQQAAPLPLPPQPAGSIKR-------GT 412
            ||...|.:...|.|   |..|||              .:..:||.|......:::.       ||
 Worm    33 RPASGQASPLTSNG---SLSPPQYADDQGSVSYNLDSPRDLSPLLLSELACLNMREVVARPGLGT 94

  Fly   413 IGKPGQVGINYLDLDLS--KMPSVAYHYDV------------------KIMPERPKKFYRQAFEQ 457
            ||:...|..|:..:||.  ||..:.||.::                  |.:.:.|..|:.:
 Worm    95 IGRQIPVKSNFFAMDLKNPKMVVIQYHVEIHHPGCRKLDKDEMRIIFWKAVSDHPNIFHNK---- 155

  Fly   458 FRVDQLGGAVLAYDGKASCYSVDKLPLNSQNPEVTV-------TDRNGRTLRYTIEIKETGDSTI 515
                    ..|||||....|:|.:|........|.:       .|...|| |..|.|:..|...:
 Worm   156 --------FALAYDGAHQLYTVARLEFPDDQGSVRLDCEASLPKDNRDRT-RCAISIQNVGPVLL 211

  Fly   516 DL-KSLTTYMNDRIFDKPMRAMQCVEVVL------------------ASPCHNKAIRVGRSFFKM 561
            :: ::.|..:::|:    :..:|.::::.                  .|.|:......|::.
 Worm   212 EMQRTRTNNLDERV----LTPIQILDIICRQSLTCPLLKNSANFYTWKSSCYRIPTAAGQAL--- 269

  Fly   562 SDPNNRHELDDGYEALVGLYQAFMLGD--RPFLNVDISHKSF-----PISMPMIEYLERFSLKAK 619
                   :|:.|.|...|.:.:..:..  ||.||:|::|.:|     .:...|.:.|...:.|..
 Worm   270 -------DLEGGKEMWTGFFSSAHIASNYRPLLNIDVAHTAFYKTRITVLQFMCDVLNERTSKPN 327

  Fly   620 INN-----------------------------------------------TTNLD---------- 627
            .||                                               |..:|
 Worm   328 RNNPRGPGGPGGPGGYRGGRGGGRGGSYGNFGNRGPPGANVRDDFGGNGLTFTMDTLSRDTQLSS 392

  Fly   628 YSRRFLEPFLRG--INVVYTPPQSFQSAPRVYRVNGLSRAPASSETF---EHDGKKV--TIASYF 685
            :..|.....:||  |...:.|     :|.|||:||.| :.||....|   :.:|::|  ::|.||
 Worm   393 FETRIFGDAIRGMKIRAAHRP-----NAIRVYKVNSL-QLPADKLMFQGIDEEGRQVVCSVADYF 451

  Fly   686 HSRNYPLKFPQLHCLNVGSSIKSILLPIELCSIEEGQALNRKDGATQVANMIKYAATSTNVRKRK 750
            ..:..|||:|:|.||:||...::|.||:|.|.|:..|..|:|....|.:.:||.||.....|:.:
 Worm   452 SEKYGPLKYPKLPCLHVGPPTRNIFLPMEHCLIDSPQKYNKKMSEKQTSAIIKAAAVDATQREDR 516

  Fly   751 IMNLLQYFQHNLDPTISRFGIRIANDFIVVSTRVLSPPQVEYHSKR-----FTMVKNGSWRMDGM 810
            |..|........||.:..||:.:::..|..:.||:.||.:.:....     ....|:|||.||..
 Worm   517 IKQLAAQASFGTDPFLKEFGVAVSSQMIQTTARVIQPPPIMFGGNNRSVNPVVFPKDGSWTMDNQ 581

  Fly   811 KFLEPKPKAHKCAVLYCDPRSGRKMNYTQLNDFGNLIISQGKAVNISL---DSDVTYRPFTDDER 872
            ....|........:...|||     :.|.|..|...:..:..|:.::.   ...|.|....:|..
 Worm   582 TLYMPATCRSYSMIALVDPR-----DQTSLQTFCQSLTMKATAMGMNFPRWPDLVKYGRSKEDVC 641

  Fly   873 SLDTIFADLKRSQHDL--AIVIIPQFRIS--YDTIKQKAELQHGILTQCIKQFTVERKCNNQTIG 933
            :|.|..||..|..:.:  .|:::.|.:.|  |.|:|:::::.|||::||:....|.|. ...|..
 Worm   642 TLFTEIADEYRVTNTVCDCIIVVLQSKNSDIYMTVKEQSDIVHGIMSQCVLMKNVSRP-TPATCA 705

  Fly   934 NILLKINSKLNGINHKIKDDP---RLPMMKNTMYIGADVTHPSPDQ--REIPSVVGVAASHDPYG 993
            ||:||:|.|:.|||.:|..|.   :..:.:.||.:|.|||||:..:  ..:|||..:.|:.|...
 Worm   706 NIVLKLNMKMGGINSRIVADKITNKYLVDQPTMVVGIDVTHPTQAEMRMNMPSVAAIVANVDLLP 770

  Fly   994 ASYNMQYRLQRGALEEIEDMFSITLEHLRVYKEYRNAYPDHIIYYRDGVSDGQFPKIKNEELRCI 1058
            .||....::|:...|.:..:.....|.:..:..:....|..||.||||||:|||.::..||::.|
 Worm   771 QSYGANVKVQKKCRESVVYLLDAIRERIITFYRHTKQKPARIIVYRDGVSEGQFSEVLREEIQSI 835

  Fly  1059 KQACDKVG--CKPKICCVIVVKRHHTRFFPSGDVTTSNKFNNVDPGTVVDRTIVHPNEMQFFMVS 1121
            :.||..:.  .:|.|..::|.||||.|.|.........|..||.|||.||..||.|....|::.|
 Worm   836 RTACLAIAEDFRPPITYIVVQKRHHARIFCKYQNDMVGKAKNVPPGTTVDTGIVSPEGFDFYLCS 900

  Fly  1122 HQAIQGTAKPTRYNVIENTGNLDIDLLQQLTYNLCHMFPRCNRSVSYPAPAYLAHLVAARGRVYL 1186
            |..:|||::|.||:|:.:......|.:|.:||.:||.:.||.||||.|.|.|.|.|||.|.|.::
 Worm   901 HYGVQGTSRPARYHVLLDECKFTADEIQSITYGMCHTYGRCTRSVSIPTPVYYADLVATRARCHV 965

  Fly  1187 ----------------------------TGTNRFLDLKKEYAKR--------------------- 1202
                                        ||:.:.   ||.||..
 Worm   966 KRKLGLADNNDCDTNSRSSTLASLLNVRTGSGKG---KKSYAPSVDDESYSLSDATSDQILQDCV 1027

  Fly  1203 TIVPEFMKKNPMYFV 1217
            ::..:|  |:.|||:
 Worm  1028 SVATDF--KSRMYFI 1040

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AGO2	NP_730054.1	ArgoN	471..543	CDD:465134	16/79 (20%)
		ArgoL1	554..601	CDD:462567	11/48 (23%)
		PAZ	605..719	CDD:239207	41/177 (23%)
		Piwi_ago-like	764..1186	CDD:240015	141/440 (32%)
alg-4	NP_499191.1	ArgoN	154..235	CDD:465134	19/97 (20%)
		ArgoL1	262..306	CDD:462567	12/53 (23%)
		PAZ_argonaute_like	374..484	CDD:239212	36/115 (31%)
		Piwi_ago-like	530..964	CDD:240015	141/439 (32%)