Protein Alignment AGO2 and ppw-1

DIOPT Version :10

• Sequence 1: NP_730054.1
• Gene: AGO2 / 39683
• FlyBaseID: FBgn0087035
• Length: 1217
• Species: Drosophila melanogaster
• Sequence 2: NP_491323.2
• Gene: ppw-1 / 172013
• WormBaseID: WBGene00004093
• Length: 887
• Species: Caenorhabditis elegans
• Alignment Length: 925
• Identity: 220/925 - (23%)
• Similarity: 370/925 - (40%)
• Gaps: 190/925 - (20%)

  Fly   377 QTQSQGQYQSRGP--PQQQQAAPLPLPPQPAGSIKRGT-----------IGKPGQ------VGIN 422
            :.|.:..:.|..|  |..|:....||..:...:::|||           ..||.|      |.:|
 Worm     2 EKQLEAMFVSDRPAAPAAQKLGTAPLAAKKTRNVERGTKVNIDTNIRKLTIKPNQPIYKYAVQVN 66

  Fly   423 YL---------DLDLSKMPSVAYHYDVKIMPERPKKFYRQAFEQFRVDQLGGAVLAYDGKASCYS 478
            |:         .:::||.......:|..  ..|.:|.|.:|.:::...:.||... ||.:||.|:
 Worm    67 YVFRKPDGTEATIEMSKSAKKGTEHDND--KTRCQKVYNEAIKRYDELKTGGPFF-YDRQASLYT 128

  Fly   479 VDKLPLNSQNPEVTVTDR-----NGRTLRYTI-EIKETGDSTIDLKSLTTYMNDRIFDKPMRAMQ 537
            :.|  |.:::....|||:     |.:..::.: ::.::..||.:....||.......||.:  ::
 Worm   129 LTK--LKNESISFVVTDKICKRQNFKEAQFVLKKVDQSFQSTSNDVIRTTNSCPANADKTL--LE 189

  Fly   538 CVEVVLASPC-HNK-AIRVGRSFFKMSDPNNRHELDDGYE--ALVGLYQAFMLG----------- 587
            .:.::::.|. .|| .|.||.....:.||.   .:|..|:  |...||..  :|
 Worm   190 AMNIIVSGPAFENKNVITVGACVHYLIDPT---VVDVAYKEYAEGQLYSG--VGASKSVKTLEGT 249

  Fly   588 DRP----FLNVDISHKSF-PISMPMIEYLERF-----SLKAKINNTTNLDYSRRFLEPFLRGINV 642
            |:.    |:..::....| |...|::|.|:.|     :|||      |...::|..:.|: |::|
 Worm   250 DKKVPSLFMTTEMKTTLFHPDYAPLVELLQTFRGFSTTLKA------NSPAAQRIEKAFV-GLDV 307

  Fly   643 VYTPPQSFQSAPRVYRVN-GLS-----------RAPASSETFEHDGKK---VTIASYFHSR-NYP 691
            |..           |.|: ||.           ...|....||.:...   ..:..||..: ...
 Worm   308 VLN-----------YGVHKGLGEDGVVMKIRRFHTSAKETCFEVEKSTREFTNVFDYFKKKYGIT 361

  Fly   692 LKFPQLHCLNVGSSIKSILLPIE---LC---SIEEGQALNRKDGATQVANMIKYAATSTNVRKR- 749
            ||:|.|..:........|..|.|   ||   ::...|.:|.:.     |:|||.:|...::||.
 Worm   362 LKYPDLFTIEAKGKQGKIHFPAEVLLLCPNQTVTNDQMINNEQ-----ADMIKMSAAQPHIRKTT 421

  Fly   750 --KIMNLLQYFQHNLDPTISRFGIRIANDFIVVSTRVLSPPQVEYHSKRFTMVKNGSWRMDGMKF 812
              .|:..:....:|:      :|.....|.:.:...||..|::.:...:...:.|...|.
 Worm   422 TDTIVRNVGLASNNI------YGFIKVEDPVNLEGMVLPKPKIAFAGNQLADLANPKSRF----- 475

  Fly   813 LEPKPKAHKCAVLYCDPRSGRK--MNYTQLNDFGNL-------IISQG-KAVNISLDSDVTYRPF 867
                |.....|..|.|.:...|  :.:.|..:...|       :::.| |..|.::...:
 Worm   476 ----PTDFNRAGQYYDAKELTKWELVFVQNEEVQGLAKQLADEMVNNGMKCSNPTMSFII----- 531

  Fly   868 TDDERSLDTIFADLKRSQHDLAIVIIPQFRISYDTIKQKAELQHGILTQCIKQFTVERKCNN-QT 931
               ...|:.||...|.:...|...:: :.|.:|....:..|.::.:|||.|:..|.|:.... ||
 Worm   532 ---RGDLEPIFKKAKAAGTQLLFFVV-KSRYNYHQQIKALEQKYDVLTQEIRAETAEKVFRQPQT 592

  Fly   932 IGNILLKINSKLNGINHKIKDDP-RLPMMKNTMYIGADVTHPSPDQREIPSVVGVAAS----HDP 991
            ..||:.|.|.||.|:|:.|..:. ..|   |.:.:|...:.......:.|..||.||:    |..
 Worm   593 RLNIINKTNMKLGGLNYAIGSEAFNKP---NRLIVGFVTSQRVGGNPDYPISVGFAANMLKHHQK 654

  Fly   992 YGASYNMQYRLQRGALEEIEDMFSITLEH--LRVYK---EYRNAYPDHIIYYRDGVSDGQFPKIK 1051
            :...|...:|        ..|:|...::.  |.::|   |.|.. ||.|:.|.:|||:|||..|.
 Worm   655 FAGGYVYVHR--------DRDVFGSIIKDTLLAIFKTCTEQRGR-PDDILLYFNGVSEGQFSMIN 710

  Fly  1052 NEELRCIKQAC---DKVGC---KPKICCVIVVKRHHTRFFPSGDVTTSNKFNNVDPGTVVDRTIV 1110
            .|....:|:||   .|.|.   :|.|..:...|.|:.|.:.|    ...:..|::||||||.|||
 Worm   711 EEFSARVKEACMAFQKEGTPPFRPHITIIASSKAHNERLYKS----DKGRIVNLEPGTVVDHTIV 771

  Fly  1111 HPNEMQFFMVSHQAIQGTAKPTRYNVIENT--GNLDIDL--LQQLTYNLCHMFPRCNRSVSYPAP 1171
            .....:::..|..|.|||||.|::.:|..|  |.....|  |:|||.:||:........|..|.|
 Worm   772 SNVYTEWYHASAVARQGTAKATKFTLIFTTKAGPQAEPLWHLEQLTNDLCYDHQIVFHPVGLPVP 836

  Fly  1172 AYLAHLVAARGRVYL 1186
            .|:|...:.||.:.|
 Worm   837 LYIADRYSQRGAMVL 851

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AGO2	NP_730054.1	ArgoN	471..543	CDD:465134	16/77 (21%)
		ArgoL1	554..601	CDD:462567	12/63 (19%)
		PAZ	605..719	CDD:239207	31/140 (22%)
		Piwi_ago-like	764..1186	CDD:240015	117/452 (26%)
ppw-1	NP_491323.2	PAZ_argonaute_like	272..389	CDD:239212	29/134 (22%)
		Piwi-like	444..849	CDD:239208	116/438 (26%)