Protein Alignment CG7275 and Dcaf13

DIOPT Version :10

• Sequence 1: NP_648767.1
• Gene: CG7275 / 39669
• FlyBaseID: FBgn0036500
• Length: 446
• Species: Drosophila melanogaster
• Sequence 2: NP_941008.2
• Gene: Dcaf13 / 223499
• MGIID: 2684929
• Length: 445
• Species: Mus musculus
• Alignment Length: 442
• Identity: 262/442 - (59%)
• Similarity: 335/442 - (75%)
• Gaps: 1/442 - (0%)

  Fly     1 MKVKMISRNPDNYVRETKLQQHKMPRNYDPSLHPLEGPREYVRALNATKLDRVFAKPFVCNLSGH 65
            |||||:|||||||||||||...::||||||:|||.|.|||||||||||||:|||||||:.:|.||
Mouse     1 MKVKMLSRNPDNYVRETKLDIQRVPRNYDPTLHPFEVPREYVRALNATKLERVFAKPFLASLDGH 65

  Fly    66 RDGVSCFGKHPKQLSTLATGAYDGEVRIWDLANRISSRNFVAHDGFVRGIAYTQNGGRIFTVGDD 130
            ||||:|..||||.|:::.:||.||||:||:|..|...|...||:|||||:.....|...||||||
Mouse    66 RDGVNCLAKHPKSLASVLSGACDGEVKIWNLTKRKCIRTIQAHEGFVRGMCTRFCGTSFFTVGDD 130

  Fly   131 KTIKVWKAEAPEVGEDEVPVNTILSKFGLHGISHNRRDNKFATCGEVCAIWDERHNDPLKTLKWG 195
            ||:|.||.:.|..||:|.|:.|:|.|....||.|:.:|..|||||:...||||:...|:.::.||
Mouse   131 KTVKQWKMDGPGYGEEEEPLYTVLGKTVYTGIDHHWKDPVFATCGQQVDIWDEQRTSPVCSMNWG 195

  Fly   196 VDTLHTISYNPVETSILACCASDRSIILYDQREAQPLRKVVLTMKSNKLAWNPMEAFNFTVANED 260
            .|::.::.:|||||.:|..|||||:|:|||.|:|.||:||:|.|::|.:.||||||||||.||||
Mouse   196 FDSISSVKFNPVETFLLGSCASDRNIVLYDMRQATPLKKVILEMRTNTICWNPMEAFNFTAANED 260

  Fly   261 CNLYTFDTRKLQTPLKVHFDHVSAVTDVDYSPTGKEFVSASYDKTIRIYNAHHSHSRDIYHTKRM 325
            .||||||.|.|.||:.||.||||||.|||||||||||||||:||:|||:....|.||::||||||
Mouse   261 YNLYTFDMRALDTPVMVHMDHVSAVLDVDYSPTGKEFVSASFDKSIRIFPVDKSRSREVYHTKRM 325

  Fly   326 QHVVCVAWSLDNRYVFSGSDEMNVRMWKANASEKLGVIRPRERVNFNYQEALKQKYAAHPQIKRI 390
            |||:||.|:.|::|:..||||||:|:|||||||||||:..||:...:|.:.||:|:..||.:|||
Mouse   326 QHVMCVKWTSDSKYIMCGSDEMNIRLWKANASEKLGVLTSREKAANDYNQKLKEKFQYHPHVKRI 390

  Fly   391 ARHRQVPRHVLNAQKKMRTVKEKEQVKEANVRKHTKKSKKVPYVSEKKKHVL 442
            ||||.:|:.:.:..::.|.:||..:.||.|.|||:|.. .||.|||:||||:
Mouse   391 ARHRHLPKSIYSQIQEQRVMKEARRRKEMNRRKHSKPG-SVPIVSERKKHVV 441

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG7275	NP_648767.1	WD40	62..353	CDD:475233	168/290 (58%)
		WD40 repeat	113..154	CDD:293791	20/40 (50%)
		WD40 repeat	159..193	CDD:293791	14/33 (42%)
		WD40 repeat	200..236	CDD:293791	20/35 (57%)
		WD40 repeat	242..277	CDD:293791	25/34 (74%)
		WD40 repeat	285..327	CDD:293791	30/41 (73%)
		WD40 repeat	328..352	CDD:293791	13/23 (57%)
		Sof1	354..441	CDD:427753	42/86 (49%)
Dcaf13	NP_941008.2	WD40	59..353	CDD:238121	168/293 (57%)
		WD 1	64..104		22/39 (56%)
		WD40 repeat	70..107	CDD:293791	17/36 (47%)
		WD 2	107..146		21/38 (55%)
		WD40 repeat	112..154	CDD:293791	21/41 (51%)
		WD 3	149..191		18/41 (44%)
		WD40 repeat	162..195	CDD:293791	13/32 (41%)
		WD 4	194..234		22/39 (56%)
		WD40 repeat	199..267	CDD:293791	42/67 (63%)
		WD 5	236..276		27/39 (69%)
		WD 6	280..319		29/38 (76%)
		WD40 repeat	285..327	CDD:293791	30/41 (73%)
		WD 7	323..362		27/38 (71%)
		WD40 repeat	328..352	CDD:293791	13/23 (57%)
		Required for nucleolar location. /evidence=ECO:0000269|PubMed:30111536	353..441		44/88 (50%)
		Sof1	354..440	CDD:427753	42/86 (49%)