DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Best4 and BEST4

DIOPT Version :9

Sequence 1:	NP_001097609.1	Gene:	Best4 / 39660	FlyBaseID:	FBgn0036491	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_695006.1	Gene:	BEST4 / 266675	HGNCID:	17106	Length:	473	Species:	Homo sapiens

Alignment Length:	552	Identity:	209/552 - (37%)
Similarity:	293/552 - (53%)	Gaps:	127/552 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MTVTYTSRVSTSSVLSNFLGLLVRWRGSIYKLIWLDLIVFFGLYCLLAITYRLLVNEEGKRFFEA 65
            |||:||.:|:.:. ...|.|||:|||||||||::.:.::|..||.:|:||||||:.:|.:..:..
Human     1 MTVSYTLKVAEAR-FGGFSGLLLRWRGSIYKLLYKEFLLFGALYAVLSITYRLLLTQEQRYVYAQ 64

  Fly    66 IMSYCEKNGSLIPLSFVLGFFVRIVMNRWWDQYTTIPWPDGIAILISTSIHGSDDRARVMRRTIL 130
            :..||.::..||||||||||:|.:|:||||.|||:||.||.:..:||.|:||.|.|.|::|||::
Human    65 VARYCNRSADLIPLSFVLGFYVTLVVNRWWSQYTSIPLPDQLMCVISASVHGVDQRGRLLRRTLI 129

  Fly   131 RYVCLCQVIVFTMISPRVKRRFPTYTQIIEAGFLLENEKKIIEAMDQAFPSYPKHWMPIVWAASI 195
            ||..|..|:|...:|.||.:||||...:::|||:.:.|:|..|::...|   .|:|:|.||..::
Human   130 RYANLASVLVLRSVSTRVLKRFPTMEHVVDAGFMSQEERKKFESLKSDF---NKYWVPCVWFTNL 191

  Fly   196 VMRARRENKIRDDYAVKTIIDELNQLRGNCGFLLYYDWISVPLVYTQVVTVATYSFFLFSVLGQQ 260
            ..:|||:.:||||.|:..:::|||:.|..|..|.:|||||:|||||||||:|.||||..|::|:|
Human   192 AAQARRDGRIRDDIALCLLLEELNKYRAKCSMLFHYDWISIPLVYTQVVTIAVYSFFALSLVGRQ 256

  Fly   261 WNESHS--------------------DEDGTRIRRWFPILTVLQFFFYMGWLKVAETLINPFGED 305
            :.|..:                    |.|     .:.|:.|:||||||.|||||||.:|||||||
Human   257 FVEPEAGAAKPQKLLKPGQEPAPALGDPD-----MYVPLTTLLQFFFYAGWLKVAEQIINPFGED 316

  Fly   306 DDDFELNWIIDRNLTVSYCIVDEMHQEHPELVKDQYWEEVFPNEIPYAQPKMRQNPPAASTAYME 370
            |||||.|.:|||||.||...||||:|..|...|||||:|        .||:    ||.......|
Human   317 DDDFETNQLIDRNLQVSLLSVDEMYQNLPPAEKDQYWDE--------DQPQ----PPYTVATAAE 369

  Fly   371 SQSKLQKRHESAMSTLSTRSRNNFRQNFLGRPSATGSYSDSIQMEDGPSRVTFSENQFDLPHDEA 435
            |.                            |||..|| :.:::|.|.|.:        .|..:.:
Human   370 SL----------------------------RPSFLGS-TFNLRMSDDPEQ--------SLQVEAS 397

  Fly   436 NSSHKPSQSTIDFNDLIEQRRRERRERIRHRFLDMQSTHLRHDTSGAPYTITVL----------R 490
            ..|.:|:.:.              :..:..|||.:          |||.....|          |
Human   398 PGSGRPAPAA--------------QTPLLGRFLGV----------GAPSPAISLRNFGRVRGTPR 438

  Fly   491 PP---------------SDETLSESQEAGDRA 507
            ||               :.....||.|:||.|
Human   439 PPHLLRFRAEEGGDPEAAARIEEESAESGDEA 470

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Best4	NP_001097609.1	Bestrophin	8..319	CDD:279411	155/330 (47%)
BEST4	NP_695006.1	Bestrophin	8..331	CDD:395843	156/331 (47%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	379..408		6/50 (12%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	428..473		9/43 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155282
Domainoid	1	1.000	355	1.000	Domainoid score	I996
eggNOG	1	0.900	-	-		E1_KOG3547
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H129743
Inparanoid	1	1.050	396	1.000	Inparanoid score	I1965
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D145964at33208
OrthoFinder	1	1.000	-	-		FOG0001515
OrthoInspector	1	1.000	-	-		mtm8455
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10736
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2974
SonicParanoid	1	1.000	-	-		X320
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.890