DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Best4 and Best1

DIOPT Version :9

Sequence 1:	NP_001097609.1	Gene:	Best4 / 39660	FlyBaseID:	FBgn0036491	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_036043.2	Gene:	Best1 / 24115	MGIID:	1346332	Length:	551	Species:	Mus musculus

Alignment Length:	564	Identity:	198/564 - (35%)
Similarity:	293/564 - (51%)	Gaps:	105/564 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MTVTYTSRVSTSSVLSNFLGLLVRWRGSIYKLIWLDLIVFFGLYCLLAITYRLLVNEEGKRFFEA 65
            ||:|||::|:.:. |.:|..||:.||||||||::.:.:||..||..:...||::::.:.:..||.
Mouse     1 MTITYTNKVANAR-LGSFSSLLLCWRGSIYKLLYGEFLVFIFLYYSIRGLYRMVLSSDQQLLFEK 64

  Fly    66 IMSYCEKNGSLIPLSFVLGFFVRIVMNRWWDQYTTIPWPDGIAILISTSIHGSDDRARVMRRTIL 130
            :..||:....|||:||||||:|.:|::|||.||..:||||.:.|.:|:.:.|.|:..|::|||::
Mouse    65 LALYCDSYIQLIPISFVLGFYVTLVVSRWWSQYENLPWPDRLMIQVSSFVEGKDEEGRLLRRTLI 129

  Fly   131 RYVCLCQVIVFTMISPRVKRRFPTYTQIIEAGFLLENEKKIIEAMDQAFPSYPKHWMPIVWAASI 195
            ||..|.||::...||..|.:||||...::.|||:...|.|.::.:.....::   |:|.||.|::
Mouse   130 RYAILGQVLILRSISTSVYKRFPTLHHLVLAGFMTHGEHKQLQKLGLPHNTF---WVPWVWFANL 191

  Fly   196 VMRARRENKIRDDYAVKTIIDELNQLRGNCGFLLYYDWISVPLVYTQVVTVATYSFFLFSVLGQQ 260
            .|:|....:|||...::::::|:..||..||.|..|||||:|||||||||||.|||||..::|:|
Mouse   192 SMKAYLGGRIRDTVLLQSLMNEVCTLRTQCGQLYAYDWISIPLVYTQVVTVAVYSFFLACLIGRQ 256

  Fly   261 WNESHSDEDGTRIRRWFPILTVLQFFFYMGWLKVAETLINPFGEDDDDFELNWIIDRNLTVSYCI 325
            :...:.|..|..:....|:.|:|||.||||||||||.|||||||||||||.||||||||.||...
Mouse   257 FLNPNKDYPGHEMDLVVPVFTILQFLFYMGWLKVAEQLINPFGEDDDDFETNWIIDRNLQVSLLS 321

  Fly   326 VDEMHQEHPELVKDQYWEEVFPNEIPY--AQPKMRQNPPAAST-----------AYMESQSKLQK 377
            ||.|||..|.:.:|.||.|..| :.||  |..:.|::....||           .:.:.::...|
Mouse   322 VDGMHQNLPPMERDMYWNEAAP-QPPYTAASARSRRHSFMGSTFNISLKKEDLELWSKEEADTDK 385

  Fly   378 RHESAMSTLSTRSRNNFRQNFLG---------------------RPSATGSYSDSIQMEDGPSRV 421
            :.....||:..         |||                     .|...|...|:.|
Mouse   386 KESGYSSTIGC---------FLGLQPKNYHLPLKDLKTKLLCSKNPLLEGQCKDANQ-------- 433

  Fly   422 TFSENQFDL-------------------PH--DEANSSHKPSQS-----------TIDFNDLIEQ 454
               :||.|:                   .|  .:|.|||...||           :.|:.::...
Mouse   434 ---KNQKDVWKFKGLDFLKCVPRFKRRGSHCGPQAPSSHPTEQSAPSSSDTGDGPSTDYQEICHM 495

  Fly   455 RRR----------ERRERIRHRFLDMQSTH----LRHDTSGAPY 484
            :::          ...|.::.|.||..||:    ::......||
Mouse   496 KKKTVEFNLNIPESPTEHLQQRRLDQMSTNIQALMKEHAESYPY 539

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Best4	NP_001097609.1	Bestrophin	8..319	CDD:279411	143/310 (46%)
Best1	NP_036043.2	Bestrophin	8..315	CDD:279411	143/310 (46%)
Best1	NP_036043.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	459..489		7/29 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845748
Domainoid	1	1.000	355	1.000	Domainoid score	I981
eggNOG	1	0.900	-	-		E1_KOG3547
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	396	1.000	Inparanoid score	I1945
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D145964at33208
OrthoFinder	1	1.000	-	-		FOG0001515
OrthoInspector	1	1.000	-	-		mtm8695
orthoMCL	1	0.900	-	-		OOG6_101870
Panther	1	1.100	-	-	O	PTHR10736
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X320
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.760