Protein Alignment Tak1 and LCK

DIOPT Version :10

• Sequence 1: NP_524080.1
• Gene: Tak1 / 39659
• FlyBaseID: FBgn0026323
• Length: 678
• Species: Drosophila melanogaster
• Sequence 2: NP_001426075.1
• Gene: LCK / 3932
• HGNCID: 6524
• Length: 567
• Species: Homo sapiens
• Alignment Length: 262
• Identity: 75/262 - (28%)
• Similarity: 132/262 - (50%)
• Gaps: 21/262 - (8%)

  Fly    19 ITLREKVGHGSYGVVCKAVWRDKL-VAVKEFFASAEQKD-IEKEVKQLSRVKHPNIIALHGISSY 81
            :.|.|::|.|.:|.|....:.... ||||.....:...| ...|...:.:::|..::.|:.:.:
Human   303 LKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRLVRLYAVVT- 366

  Fly    82 QQATYLIMEFAEGGSLHNFLHGKVKPAYSLAHAMSWARQCAEGLAYLHAMTPKPLIHRDVKPLNL 146
            |:..|:|.|:.|.|||.:||........::...:..|.|.|||:|::.   .:..||||::..|:
Human   367 QEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIE---ERNYIHRDLRAANI 428

  Fly   147 LLTNKGRNLKICDFGTVADKSTMMTNNRGSA--------AWMAPEVFEGSKYTEKCDIFSWAIVL 203
            |:::. .:.||.|||.    :.::.:|..:|        .|.|||......:|.|.|::|:.|:|
Human   429 LVSDT-LSCKIADFGL----ARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILL 488

  Fly   204 WEVLSR-KQPFKGIDNAYTIQWKIYKGERPPLLTTCPKRIEDLMTACWKTVPEDRPSMQYIVGVM 267
            .|:::. :.|:.|:.|...|| .:.:|.|......||:.:..||..|||..|||||:..|:..|:
Human   489 TEIVTHGRIPYPGMTNPEVIQ-NLERGYRMVRPDNCPEELYQLMRLCWKERPEDRPTFDYLRSVL 552

  Fly   268 HE 269
            .:
Human   553 ED 554

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tak1	NP_524080.1	STKc_TAK1	25..275	CDD:270960	73/256 (29%)
LCK	NP_001426075.1	None