Protein Alignment Tak1 and Ankk1

DIOPT Version :10

• Sequence 1: NP_524080.1
• Gene: Tak1 / 39659
• FlyBaseID: FBgn0026323
• Length: 678
• Species: Drosophila melanogaster
• Sequence 2: NP_001102469.2
• Gene: Ankk1 / 367080
• RGDID: 1305538
• Length: 784
• Species: Rattus norvegicus
• Alignment Length: 762
• Identity: 160/762 - (20%)
• Similarity: 291/762 - (38%)
• Gaps: 220/762 - (28%)

  Fly    16 FSEI-TLREKVGHGSYGVVCKAVWRDKLVAVKEFFASAEQKDIEKEVKQLSRVKHPNIIALHGIS 79
            ||:: ..|.|.....|.:.|..       .:::...|:|...:.:|..::.::|...|::::|:.
  Rat    45 FSQVFQARHKRWRTQYAIKCSP-------CLQKETTSSEVSCLFEEAVKMEKIKFQYIVSIYGVC 102

  Fly    80 SYQQATYLIMEFAEGGSLHNFLHGKVKPAYSLAHAMSW--ARQCAEGLAYLHAMTPKPLIHRDVK 142
              :|...::|||...|||.     |:.|.:||...:.:  ..:.:..:.:||::.| ||:|.|:|
  Rat   103 --KQPLGIVMEFMANGSLE-----KILPTHSLCWQLKFRIIHETSLAMNFLHSIKP-PLLHLDLK 159

  Fly   143 PLNLLLTNKGRNLKICDFGTV--ADKSTM-----MTNNRGSAAWMAPEVF------EGSKYTEKC 194
            |.|:||.| ..::||.|||..  .::||.     .:..||:.:::.||:|      .|.:|
  Rat   160 PGNILLDN-NMHVKISDFGLSKWMEQSTQKQYIERSALRGTLSYIPPEMFLENNKAPGPEY---- 219

  Fly   195 DIFSWAIVLWEVLSRKQPFKGIDNAYTIQWKIYKGERPPLLTTCPK------RIEDLMTACWKTV 253
            |::|:.||:||:|::|:|:.|: |..||..::..|.||.|.....:      ::.|||..||...
  Rat   220 DVYSFGIVVWEILTQKKPYAGL-NMMTIIIQVAAGMRPSLHDVSAEWPEEAHQMVDLMKLCWDQD 283

  Fly   254 PEDRPSMQYIVGVMHEIVKDYTGADKALEYTFVNQQIVTKESDGTVAAQPDSLSSQEGELSPSST 318
            |:.||....::.....::..:.......||..:.:::..|.|    .:||.
  Rat   284 PKKRPCFLNVIIETDMLLSLFQTPVADPEYEALTRKVSYKSS----LSQPH-------------- 330

  Fly   319 QLTPTTAANANVNAIAISKTTTSSMTENTS-----------STSSDITPTNSGQLDNNPLFYMVT 372
            :..||..     |.:.:||..:..:.::..           |.|..:.|::..:....||.::|
  Rat   331 RWIPTLH-----NTLQVSKEVSQEIADSADSDDSLKWILQLSDSKSLVPSDIYENKVTPLHFLV- 389

  Fly   373 NRWDAIPEEESNESRNDSFNLTSSAEATQRLETIRNGMILMACKPMEQLTLDVE-ANGFDLSPSE 436
                                      |...||.:|   :|::    .::.:|.: |:|:  :|.
  Rat   390 --------------------------ARGSLEQVR---LLLS----HEVDVDCQTASGY--TPL- 418

  Fly   437 SSSSSTNAKSDGRERLTVTDTKPVMMT--------TDLSNNNGGIHAH---SNG-------LLSH 483
                          .:...|.:|.:..        |:|::.:|....|   .:|       ||.|
  Rat   419 --------------LIATQDQQPDLCALLLAHGADTNLADEDGWAPLHFAAQSGDDHTARLLLDH 469

  Fly   484 ANGWQARDEE------LQEQEHEQEIVN---SLDVDVDPDEDENDGTEQSLAEILDPELQPEPPI 539
            .....||:.|      |..|.:.:.|..   |...|::|.|.|.                 :.|:
  Rat   470 GALVNAREHEGWTPLHLAAQNNFENIARLLVSRQADLNPCEAEG-----------------KTPL 517

  Fly   540 PNDAESQLIYRDHRHMAKEYLSVDTNLYYAQ-DFKDKLIVQMDRTEREQKQELLRK-----MKDK 598
            ...|     |..|..:.|........|...| :.:..|.:.:::.:....|.||::     :.|.
  Rat   518 HVAA-----YFGHIGLVKLLTGQGAELDAQQRNLRTPLHLAVEKGKVRAIQHLLKRGALPDVLDH 577

  Fly   599 EGLQSL-----------YNNLQQQYASRQLAAGHHPQP-HPHPHPNQLQHPH----SH------- 640
            .|...|           :..|.:..||.:|.......| |...:...|:..|    ||
  Rat   578 NGYSPLHIAAAKGKYLIFKMLLRHGASLELCTQQGWAPLHLATYKGHLEIIHLLAKSHADLDALG 642

  Fly   641 ----PPMH---FLQDEGCGLLPGSVCGGSESVEE--GWVVIPPHHNA 678
                .|:|   |..:||. :|....||.:.:..|  ||.   |.|.|
  Rat   643 SMQWTPLHLAAFCGEEGM-MLALLQCGANPNAAEQSGWT---PLHLA 685

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tak1	NP_524080.1	STKc_TAK1	25..275	CDD:270960	71/270 (26%)
Ankk1	NP_001102469.2	Protein Kinases, catalytic domain	37..305	CDD:473864	75/280 (27%)
		ANKYR	363..640	CDD:440430	60/349 (17%)
		ANK repeat	383..411	CDD:293786	9/61 (15%)
		ANK repeat	413..444	CDD:293786	6/47 (13%)
		ANK repeat	446..477	CDD:293786	7/30 (23%)
		ANK repeat	479..510	CDD:293786	7/30 (23%)
		ANK repeat	512..542	CDD:293786	7/51 (14%)
		ANKYR	526..783	CDD:440430	34/164 (21%)
		ANK repeat	547..576	CDD:293786	4/28 (14%)
		ANK repeat	578..609	CDD:293786	6/30 (20%)
		ANK repeat	612..642	CDD:293786	6/29 (21%)
		ANK repeat	644..675	CDD:293786	8/31 (26%)
		ANK repeat	677..708	CDD:293786	5/12 (42%)
		ANK repeat	710..741	CDD:293786