DRSC/TRiP Functional Genomics Resources

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Protein Alignment Tak1 and Ripk1

DIOPT Version :10

Sequence 1:NP_524080.1 Gene:Tak1 / 39659 FlyBaseID:FBgn0026323 Length:678 Species:Drosophila melanogaster
Sequence 2:NP_033094.3 Gene:Ripk1 / 19766 MGIID:108212 Length:656 Species:Mus musculus


Alignment Length:527 Identity:134/527 - (25%)
Similarity:214/527 - (40%) Gaps:113/527 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 SLDALQAAYVDFSEITLREKVGHGSYGVVCKAVWRDK-LVAVKEFFAS---AEQKDI-EKEVKQL 64
            |||.::.|..|..|.|   .:..|.:|.|.....|.. .|.:|:.:..   ||..:: .:|.|.:
Mouse     6 SLDNIKMASSDLLEKT---DLDSGGFGKVSLCYHRSHGFVILKKVYTGPNRAEYNEVLLEEGKMM 67

  Fly    65 SRVKHPNIIALHGISSYQQATYLIMEFAEGGSLHNFLHGKVKPAYSLAHAMSWARQCAEGLAYLH 129
            .|::|..::.|.||...:....|:||:.|.|:|.:.|..::....||...:  ..:..||:.|||
Mouse    68 HRLRHSRVVKLLGIIIEEGNYSLVMEYMEKGNLMHVLKTQIDVPLSLKGRI--IVEAIEGMCYLH 130

  Fly   130 AMTPKPLIHRDVKPLNLLLTNKGRNLKICDFGTVADK-----------------STMMTNNRGSA 177
               .|.:||:|:||.|:|: ::..::||.|.|..:.|                 ||...||.|:.
Mouse   131 ---DKGVIHKDLKPENILV-DRDFHIKIADLGVASFKTWSKLTKEKDNKQKEVSSTTKKNNGGTL 191

  Fly   178 AWMAPEVFE--GSKYTEKCDIFSWAIVLWEVLSRKQPFKGIDNAYTIQWKIYKGERP---PLLTT 237
            .:||||...  .:|.|||.|::|:.||||.:.::|:|::.:.........|..|.||   .:|..
Mouse   192 YYMAPEHLNDINAKPTEKSDVYSFGIVLWAIFAKKEPYENVICTEQFVICIKSGNRPNVEEILEY 256

  Fly   238 CPKRIEDLMTACWKTVPEDRPSM----------------QYIVGVMHEIVKDYTGADKALEYTF- 285
            ||:.|..||..||:.:|||||:.                :|:...:..:.|:|......|:..| 
Mouse   257 CPREIISLMERCWQAIPEDRPTFLGIEEEFRPFYLSHFEEYVEEDVASLKKEYPDQSPVLQRMFS 321

  Fly   286 VNQQIVTKESDGTVAAQPDSLSSQEG-ELSP------SSTQLTPTTAANANVNAIAISKTTTSSM 343
            :....|......:.:.||.||.|.:| ::.|      ||:...|....:.:|.|         .:
Mouse   322 LQHDCVPLPPSRSNSEQPGSLHSSQGLQMGPVEESWFSSSPEYPQDENDRSVQA---------KL 377

  Fly   344 TENTSSTSSDITPTNSGQLDNNPLFYMVTNRWDAIPEEESNESRNDSFNLTSSAEATQRL-ETIR 407
            .|..|..:..|....  |....|......||    .||......:|.|       |.||. |.|:
Mouse   378 QEEASYHAFGIFAEK--QTKPQPRQNEAYNR----EEERKRRVSHDPF-------AQQRARENIK 429

  Fly   408 NGMILMACKPMEQLTLDVEANGFDLSPSESSSSSTNAKSDGRERLTVTDTKPVMMTTDLSNNNGG 472
            :                ..|.|       .|..||.::....::|:...|:.|.       |||.
Mouse   430 S----------------AGARG-------HSDPSTTSRGIAVQQLSWPATQTVW-------NNGL 464

  Fly   473 IHAHSNG 479
            .:.|..|
Mouse   465 YNQHGFG 471

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Tak1NP_524080.1 STKc_TAK1 25..275 CDD:270960 82/292 (28%)
Ripk1NP_033094.3 Protein Kinases, catalytic domain 23..291 CDD:473864 80/273 (29%)
Interaction with SQSTM1. /evidence=ECO:0000250|UniProtKB:Q13546 291..567 47/233 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 327..373 11/45 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 388..423 10/47 (21%)
RIP homotypic interaction motif (RHIM). /evidence=ECO:0000269|PubMed:18442983, ECO:0000269|PubMed:27819681, ECO:0000269|PubMed:27819682 520..536
Death_RIP1 568..653 CDD:260048
Blue background indicates that the domain is not in the aligned region.

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