DRSC/TRiP Functional Genomics Resources

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Protein Alignment Tak1 and Abl2

DIOPT Version :10

Sequence 1:NP_524080.1 Gene:Tak1 / 39659 FlyBaseID:FBgn0026323 Length:678 Species:Drosophila melanogaster
Sequence 2:NP_033725.2 Gene:Abl2 / 11352 MGIID:87860 Length:1182 Species:Mus musculus


Alignment Length:838 Identity:174/838 - (20%)
Similarity:282/838 - (33%) Gaps:260/838 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly    17 SEITLREKVGHGSYGVVCKAVWR--DKLVAVKEFFA-SAEQKDIEKEVKQLSRVKHPNIIALHGI 78
            ::||::.|:|.|.||.|...||:  ...||||.... :.|.::..||...:..:||||::.|.|:
Mouse   286 TDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGV 350

  Fly    79 SSYQQATYLIMEFAEGGSLHNFLHGKVKPAYSLAHAMSWARQCAEGLAYLHAMTPKPLIHRDVKP 143
            .:.:...|::.|:...|:|.::|....:...:....:..|.|.:..:.||.   .|..||||:..
Mouse   351 CTLEPPFYIVTEYMPYGNLLDYLRECSREEVTAVVLLYMATQISSAMEYLE---KKNFIHRDLAA 412

  Fly   144 LNLLLTNKGRN--LKICDFGTVADKSTMMTNNRGSA--------AWMAPEVFEGSKYTEKCDIFS 198
            .|.|:   |.|  :|:.|||.    |.:||.:..:|        .|.|||....:.::.|.|:::
Mouse   413 RNCLV---GENHVVKVADFGL----SRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWA 470

  Fly   199 WAIVLWEVLS-RKQPFKGID--NAYTIQWKIYKGERPPLLTTCPKRIEDLMTACWKTVPEDRPSM 260
            :.::|||:.: ...|:.|||  ..|.:..|.|:.|:|   ..||.::.:||.||||..|.|||| 
Mouse   471 FGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQP---EGCPPKVYELMRACWKWSPADRPS- 531

  Fly   261 QYIVGVMHEIVKDYTGADKALEYTFVNQQI---VTKESDGTVAAQPDSLSSQEGELSPSSTQLTP 322
                         :....:|.|..|.:..|   |.:|...|.::...........|.||.|:...
Mouse   532 -------------FAETHQAFETMFHDSSISEEVAEELGRTASSSSVVPYLPRLPLLPSKTRTLR 583

  Fly   323 TTAANAN--------VNAIAISKTTTSSMTENTSSTSSDITPTNSGQLDNNPL------------ 367
            ....|..        ..::|.|......:....:|:.|...|..  |.|.:|.            
Mouse   584 KQGENKENLDGGLDAAESLASSSAPAGFIRSTQASSGSPALPRK--QRDKSPSSLLEDAKETCFT 646

  Fly   368 ------FY--MVTNRWDAIPEEESNESR------NDSFNLTSSAEATQRLETIRNGMILMACKPM 418
                  |:  .:..|....|.:.|:..|      :..:.||.:......|:              
Mouse   647 RDRKGGFFSSFMKKRNAPTPPKRSSSFREMENQPHKKYELTGNFSPVASLQ-------------- 697

  Fly   419 EQLTLDVEANGFDLSPSESSSSSTNAKSDG----RERLTVTDTK----------------PVMMT 463
                   .|:||.::||:...:...||..|    :..|...|..                ....|
Mouse   698 -------HADGFSVAPSQQEPNLVPAKCYGGSFAQRNLCADDDSGGGGGSGTAGGGWSGITGFFT 755

  Fly   464 TDLSNNNGGIHA--------------HSNGLLSHANGWQARDEELQE-----QEHEQEIVNSLDV 509
            ..|.....|:.|              .||...|.::|...:|.....     |..:.::..::..
Mouse   756 PRLIKKTLGLRAGKPTASDDTSKPFPRSNSTSSMSSGLPEQDRMAMTLPRNCQRSKLQLERTVST 820

  Fly   510 DVDPDED---END------------GTEQSLAEILD------PELQPEPPI-------------- 539
            ...|:|:   .||            ..|:..|::|.      |...|:|.|              
Mouse   821 SSQPEENVDRANDMLPKKSEEGAAPARERPKAKLLPRGATALPLRAPDPAITESDSPGVGVAGVA 885

  Fly   540 -------------------PNDAES----------QLIYRDHRHMAKEYLS-------VDTNLY- 567
                               |.|.|.          .::...|.|.....:|       .|..|. 
Mouse   886 AAPKGKERNGGTRLGVAGVPEDGEQLGWSSPAKAVAVLPTTHNHKVPVLISPTLKHTPADVQLIG 950

  Fly   568 -YAQDFKDKLIVQMDRTEREQKQELLRKMKDKEGLQSLYNNLQQQYASRQLAAGHHPQPHPHPHP 631
             .:|..|.||:.:...|....| :..|::|.|                        ..|.|.|..
Mouse   951 TDSQGNKFKLLSEHQVTSSGDK-DRPRRVKPK------------------------CAPPPPPVM 990

  Fly   632 NQLQHPHS---------------HPPMHFLQDEGCGLLPGSVCGGSESVEEGWVVIPP 674
            ..||||.:               |.|.  .|:.|....||.:   ..|.:.|..|:||
Mouse   991 RLLQHPSTCSDPEEEPTAPPAGQHTPE--TQEGGKKAAPGPM---PSSGKPGRPVMPP 1043

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Tak1NP_524080.1 STKc_TAK1 25..275 CDD:270960 77/265 (29%)
Abl2NP_033725.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..42
CAP 2..106
SH3_Abl 111..164 CDD:212784
SH2_ABL 169..262 CDD:198189
PTKc_Abl 281..543 CDD:270645 82/283 (29%)
Kinase activation loop. /evidence=ECO:0000250 427..451 7/27 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 612..642 6/31 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 655..674 3/18 (17%)
Nuclear localization signal. /evidence=ECO:0000255 659..661 0/1 (0%)
F-actin-binding 695..930 36/255 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 765..796 5/30 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 809..858 7/48 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 964..1059 23/110 (21%)
F-actin-binding 1020..1182 8/27 (30%)
FABD 1063..1182 CDD:197885
Blue background indicates that the domain is not in the aligned region.

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