DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12316 and Msl1

DIOPT Version :9

Sequence 1:	NP_648752.1	Gene:	CG12316 / 39650	FlyBaseID:	FBgn0036483	Length:	1188	Species:	Drosophila melanogaster
Sequence 2:	NP_082998.2	Gene:	Msl1 / 74026	MGIID:	1921276	Length:	616	Species:	Mus musculus

Alignment Length:	713	Identity:	126/713 - (17%)
Similarity:	213/713 - (29%)	Gaps:	241/713 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   487 QTLDDEEQDLV--EEDQYSGAHSHGFFPRSSN--------ASYASGQRTP-------------LY 528
            |.||.|....:  .||:...|.:| |.||...        ||...|..:|             |.
Mouse    21 QRLDYERAAALGGPEDESGAAEAH-FLPRHRKLKEPGPPLASSQGGSPSPSPAGCGGGKGRGLLL 84

  Fly   529 HCRQTSSQNSNCSESSL-------LKKQVTFSPRHLGAATPNAKTGTSKKPSIKQYKPSSSNATE 586
            .......|.......|:       ..||.     .:|.....|..|.|.:|..:...|..:.:..
Mouse    85 PAGAAPGQQEESWGGSVPLPCPPPATKQA-----GIGGEPVAAGAGCSPRPKYQAVLPIQTGSIV 144

  Fly   587 SQRWKEEHRKASAKMFAKLDAKIKARSEAENVSTSQLTPTTSNASSSTPTKISGTPTRIRSTQRG 651
            ....||....|..|..|...|                 .|.|:.:...|..:.|.|.
Mouse   145 VAAAKEPTPWAGDKGGAAPPA-----------------ATASDPAGPPPLPLPGPPP-------- 184

  Fly   652 QRVALPTPPASTHSSSSP--CQIRSASTDNHNYNVDSDYSRRCFSKAAGDEVSYYNHLLTLQREN 714
               ..||..|.|.::|..  ..||.:......            ...|..:.:....:|.||.:.
Mouse   185 ---LAPTATAGTLAASEGRWKSIRKSPLGGGG------------GSGASSQAACLKQILLLQLDL 234

  Fly   715 IRRRRLNNQKKKKNRKVSQKVQKKDDKLNMLKQATKRCRKLRALNAKRK---------------- 763
            |.:::  .|.:.|.:::.:...::|..|..:::..:|.:.::..|.|.:
Mouse   235 IEQQQ--QQLQAKEKEIEELKSERDTLLARIERMERRMQLVKRDNEKERHKLLQGYEPEEREEAE 297

  Fly   764 -NEVQKLEQDLDTIRKS-------------------------APHKLPIIRL----KRCNLKTQK 798
             :|..|||:..:....|                         ...|.|:.:|    .:...||.|
Mouse   298 LSEKIKLERQPELCETSQALPSKPFSCGRSGKGHKRKTPFGNTERKTPVKKLAPEFSKVKTKTPK 362

  Fly   799 RS-LKAEEAPSVQEDILSMNSDRELQEQKKAQKPKRKRYKKVQKEQENEKYLREQEIIISQSQMV 862
            .| :|.|...|:.|.:..    |||:.|:..:||:..                    :.:..::.
Mouse   363 HSPIKEEPCGSISETVCK----RELRSQETPEKPRSS--------------------VDTPPRLS 403

  Fly   863 EEDKVEEHHAHEAPSEQQRELDLEHQQFLE--EQLLQEEHQ-----LAMHEEEHHQMDDEQESHE 920
            ...|....|    |.|:....::|...:|.  |..|...||     |.:.|      ...::...
Mouse   404 TPQKGPSTH----PKEKAFSSEMEDLPYLSTTEMYLCRWHQPPPSPLPLRE------SSPKKEET 458

  Fly   921 VARLLEDQQPAEGTHLHVENEMLAEKEQPLIEDDDQEADDQNQNEHLSDDQQQEADQQLSIEQPQ 985
            |||.|.....|..|.:...........:||     ::.:..:..|:|.|....:...:|.:::
Mouse   459 VARCLMPSSVAGETSVLAVPSWRDHSVEPL-----RDPNPSDILENLDDSVFSKRHAKLELDE-- 516

  Fly   986 EHEENQSLSQDPLDEQCTPTPNGKRRK-------RRRRFKRRCWTHVKNKKKKQWLIDYPLEFEA 1043
                                   ||||       |.:|..:|....:..||..|         |:
Mouse   517 -----------------------KRRKRWDIQRIREQRILQRLQLRMYKKKGIQ---------ES 549

  Fly  1044 DPALDTPPIQPEPAPDEQQAELVTGPVSESVAEPVAEPVAEPVSEPFAEQIAEPIAQPTPEPA 1106
            :|  :.....||  ||:.::.|:|                     ||...:|  ..:|.|:.|
Mouse   550 EP--EVTSFFPE--PDDVESLLIT---------------------PFLPVVA--FGRPLPKLA 585

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12316	NP_648752.1	PHA02666	504..>685	CDD:222914	38/210 (18%)
		GBP_C	<819..947	CDD:303769	24/134 (18%)
		coiled coil	931..943	CDD:293879	2/11 (18%)
		Trypan_PARP	<1026..1130	CDD:114603	17/81 (21%)
Msl1	NP_082998.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..116		20/100 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	152..218		16/105 (15%)
		Interaction with MSL2. /evidence=ECO:0000250	225..239		4/13 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	306..422		22/143 (15%)
		Nuclear localization signal. /evidence=ECO:0000269\|PubMed:24913909	319..348		2/28 (7%)
		PEHE	477..593	CDD:291924	30/175 (17%)
		Interaction with KAT8. /evidence=ECO:0000269\|PubMed:21217699	500..520		5/44 (11%)
		Bipartite nuclear localization signal. /evidence=ECO:0000269\|PubMed:24913909	507..521		4/38 (11%)
		Interaction with MSL3 MRG domain	552..593		12/59 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167834960
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR21656
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.030