Protein Alignment CG12316 and Msl1

DIOPT Version :10

• Sequence 1: NP_648752.1
• Gene: CG12316 / 39650
• FlyBaseID: FBgn0036483
• Length: 1188
• Species: Drosophila melanogaster
• Sequence 2: NP_082998.2
• Gene: Msl1 / 74026
• MGIID: 1921276
• Length: 616
• Species: Mus musculus
• Alignment Length: 713
• Identity: 126/713 - (17%)
• Similarity: 213/713 - (29%)
• Gaps: 241/713 - (33%)

  Fly   487 QTLDDEEQDLV--EEDQYSGAHSHGFFPRSSN--------ASYASGQRTP-------------LY 528
            |.||.|....:  .||:...|.:| |.||...        ||...|..:|             |.
Mouse    21 QRLDYERAAALGGPEDESGAAEAH-FLPRHRKLKEPGPPLASSQGGSPSPSPAGCGGGKGRGLLL 84

  Fly   529 HCRQTSSQNSNCSESSL-------LKKQVTFSPRHLGAATPNAKTGTSKKPSIKQYKPSSSNATE 586
            .......|.......|:       ..||.     .:|.....|..|.|.:|..:...|..:.:..
Mouse    85 PAGAAPGQQEESWGGSVPLPCPPPATKQA-----GIGGEPVAAGAGCSPRPKYQAVLPIQTGSIV 144

  Fly   587 SQRWKEEHRKASAKMFAKLDAKIKARSEAENVSTSQLTPTTSNASSSTPTKISGTPTRIRSTQRG 651
            ....||....|..|..|...|                 .|.|:.:...|..:.|.|.
Mouse   145 VAAAKEPTPWAGDKGGAAPPA-----------------ATASDPAGPPPLPLPGPPP-------- 184

  Fly   652 QRVALPTPPASTHSSSSP--CQIRSASTDNHNYNVDSDYSRRCFSKAAGDEVSYYNHLLTLQREN 714
               ..||..|.|.::|..  ..||.:......            ...|..:.:....:|.||.:.
Mouse   185 ---LAPTATAGTLAASEGRWKSIRKSPLGGGG------------GSGASSQAACLKQILLLQLDL 234

  Fly   715 IRRRRLNNQKKKKNRKVSQKVQKKDDKLNMLKQATKRCRKLRALNAKRK---------------- 763
            |.:::  .|.:.|.:::.:...::|..|..:::..:|.:.::..|.|.:
Mouse   235 IEQQQ--QQLQAKEKEIEELKSERDTLLARIERMERRMQLVKRDNEKERHKLLQGYEPEEREEAE 297

  Fly   764 -NEVQKLEQDLDTIRKS-------------------------APHKLPIIRL----KRCNLKTQK 798
             :|..|||:..:....|                         ...|.|:.:|    .:...||.|
Mouse   298 LSEKIKLERQPELCETSQALPSKPFSCGRSGKGHKRKTPFGNTERKTPVKKLAPEFSKVKTKTPK 362

  Fly   799 RS-LKAEEAPSVQEDILSMNSDRELQEQKKAQKPKRKRYKKVQKEQENEKYLREQEIIISQSQMV 862
            .| :|.|...|:.|.:..    |||:.|:..:||:..                    :.:..::.
Mouse   363 HSPIKEEPCGSISETVCK----RELRSQETPEKPRSS--------------------VDTPPRLS 403

  Fly   863 EEDKVEEHHAHEAPSEQQRELDLEHQQFLE--EQLLQEEHQ-----LAMHEEEHHQMDDEQESHE 920
            ...|....|    |.|:....::|...:|.  |..|...||     |.:.|      ...::...
Mouse   404 TPQKGPSTH----PKEKAFSSEMEDLPYLSTTEMYLCRWHQPPPSPLPLRE------SSPKKEET 458

  Fly   921 VARLLEDQQPAEGTHLHVENEMLAEKEQPLIEDDDQEADDQNQNEHLSDDQQQEADQQLSIEQPQ 985
            |||.|.....|..|.:...........:||     ::.:..:..|:|.|....:...:|.:::
Mouse   459 VARCLMPSSVAGETSVLAVPSWRDHSVEPL-----RDPNPSDILENLDDSVFSKRHAKLELDE-- 516

  Fly   986 EHEENQSLSQDPLDEQCTPTPNGKRRK-------RRRRFKRRCWTHVKNKKKKQWLIDYPLEFEA 1043
                                   ||||       |.:|..:|....:..||..|         |:
Mouse   517 -----------------------KRRKRWDIQRIREQRILQRLQLRMYKKKGIQ---------ES 549

  Fly  1044 DPALDTPPIQPEPAPDEQQAELVTGPVSESVAEPVAEPVAEPVSEPFAEQIAEPIAQPTPEPA 1106
            :|  :.....||  ||:.::.|:|                     ||...:|  ..:|.|:.|
Mouse   550 EP--EVTSFFPE--PDDVESLLIT---------------------PFLPVVA--FGRPLPKLA 585

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12316	NP_648752.1	PHA02666	504..>685	CDD:222914	38/210 (18%)
		PTZ00121	<732..995	CDD:173412	51/316 (16%)
		PTZ00341	<804..>926	CDD:173534	24/128 (19%)
		PRK10819	1051..>1105	CDD:236768	11/53 (21%)
Msl1	NP_082998.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..116		20/100 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	152..218		16/105 (15%)
		Interaction with MSL2. /evidence=ECO:0000250	225..239		4/13 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	306..422		22/143 (15%)
		Nuclear localization signal. /evidence=ECO:0000269|PubMed:24913909	319..348		2/28 (7%)
		PEHE	475..602	CDD:464607	30/177 (17%)
		Interaction with KAT8 HAT domain. /evidence=ECO:0000255|PROSITE-ProRule:PRU01397	498..516		4/17 (24%)
		Bipartite nuclear localization signal. /evidence=ECO:0000269|PubMed:24913909	507..521		4/38 (11%)
		Interaction with MSL3 MRG domain	552..593		12/59 (20%)