Protein Alignment CG12316 and MSL1

DIOPT Version :10

• Sequence 1: NP_648752.1
• Gene: CG12316 / 39650
• FlyBaseID: FBgn0036483
• Length: 1188
• Species: Drosophila melanogaster
• Sequence 2: NP_001352848.1
• Gene: MSL1 / 339287
• HGNCID: 27905
• Length: 614
• Species: Homo sapiens
• Alignment Length: 726
• Identity: 123/726 - (16%)
• Similarity: 216/726 - (29%)
• Gaps: 269/726 - (37%)

  Fly   487 QTLDDEEQDLV--EEDQYSGAHSHGFFPRSSN--------ASYASGQRTP------------LYH 529
            |.||.|....:  .||:...|.:| |.||...        ||...|...|            |..
Human    21 QRLDYERAAALGGPEDEPGAAEAH-FLPRHRKLKEPGPPLASSQGGSPAPSPAGCGGKGRGLLLP 84

  Fly   530 CRQTSSQNSN---------CSESSLLKKQVTFSPRHLGAATPNAKTGTSKKPSIKQYKPSSSN-- 583
            ......|...         |...:..:..:...|...||       |.|.:|..:...|..:.
Human    85 AGAAPGQQEESWGGSVPLPCPPPATKQAGIGGEPAAAGA-------GCSPRPKYQAVLPIQTGSL 142

  Fly   584 ---ATESQRWKEEHRKASAKMFAKLDAKIKARSEAENVSTSQLTPTTSNASSSTPTKISGTPTRI 645
               |.|...|..:...|::.                       ..|.|:.:...|..:.|.|.
Human   143 VAAAKEPTPWAGDKGGAASP-----------------------AATASDPAGPPPLPLPGPPP-- 182

  Fly   646 RSTQRGQRVALPTPPASTHSSS---------SPCQIRSASTDNHNYNVDSDYSRRCFSKAAGDEV 701
                     ..||..|.|.::|         ||......|                   .|..:.
Human   183 ---------LAPTATAGTLAASEGRWKSMRKSPLGGGGGS-------------------GASSQA 219

  Fly   702 SYYNHLLTLQRENIRRRRLNNQKKKKNRKVSQKVQKKDDKLNMLKQATKRCRKLRALNAKRKNEV 766
            :....:|.||.:.|.:::  .|.:.|.:::.:...::|..|..:::..:|.:.::..|.|.::::
Human   220 ACLKQILLLQLDLIEQQQ--QQLQAKEKEIEELKSERDTLLARIERMERRMQLVKKDNEKERHKL 282

  Fly   767 -----------------------QKLEQDLDTI---------------RK----SAPHKLPIIRL 789
                                   .:|.:...|:               ||    |...|.|:.:|
Human   283 FQGYETEEREETELSEKIKLECQPELSETSQTLPPKPFSCGRSGKGHKRKSPFGSTERKTPVKKL 347

  Fly   790 ----KRCNLKTQKRS-LKAEEAPSVQEDILSMNSDRELQEQKKAQKPKRKRYKKVQKEQENEKYL 849
                .:...||.|.| :|.|...|:.|.:..    |||:.|:..:||:..
Human   348 APEFSKVKTKTPKHSPIKEEPCGSLSETVCK----RELRSQETPEKPRSS--------------- 393

  Fly   850 REQEIIISQSQMVEEDKVEEHHAHEAPSEQQRELDLEHQQFLE--EQLLQEEHQ-----LAMHEE 907
                 :.:..::....|....|    |.|:....::|...:|.  |..|...||     |.:.|
Human   394 -----VDTPPRLSTPQKGPSTH----PKEKAFSSEIEDLPYLSTTEMYLCRWHQPPPSPLPLRE- 448

  Fly   908 EHHQMDDEQESHEVARLLEDQQPAEGTHLHVENEMLAEKEQPLIEDDDQEADDQNQNEHLSDDQQ 972
                 ...::...|||.|.....|..|.:...........:||     ::.:..:..|:|.|...
Human   449 -----SSPKKEETVARCLMPSSVAGETSVLAVPSWRDHSVEPL-----RDPNPSDLLENLDDSVF 503

  Fly   973 QEADQQLSIEQPQEHEENQSLSQDPLDEQCTPTPNGKRRK-------RRRRFKRRCWTHVKNKKK 1030
            .:...:|.:::                         ||||       |.:|..:|....:..||.
Human   504 SKRHAKLELDE-------------------------KRRKRWDIQRIREQRILQRLQLRMYKKKG 543

  Fly  1031 KQWLIDYPLEFEADPALDTPPIQPEPAPDEQQAELVTGPVSESVAEPVAEPVAEPVSEPFAEQIA 1095
            .|         |::|  :.....||  ||:.::.::|                     ||...:|
Human   544 IQ---------ESEP--EVTSFFPE--PDDVESLMIT---------------------PFLPVVA 574

  Fly  1096 --EPIAQPTPE 1104
              .|:.:.||:
Human   575 FGRPLPKLTPQ 585

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12316	NP_648752.1	PHA02666	504..>685	CDD:222914	36/223 (16%)
		PTZ00121	<732..995	CDD:173412	51/316 (16%)
		PTZ00341	<804..>926	CDD:173534	24/128 (19%)
		PRK10819	1051..>1105	CDD:236768	11/56 (20%)
MSL1	NP_001352848.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..127		22/113 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	147..217		17/122 (14%)
		Interaction with MSL2	223..237		4/13 (31%)
		PTZ00108	<243..429	CDD:240271	34/213 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	272..420		28/175 (16%)
		Nuclear localization signal. /evidence=ECO:0000250|UniProtKB:Q6PDM1	317..346		5/28 (18%)
		PEHE	473..600	CDD:464607	29/177 (16%)
		Interaction with KAT8 HAT domain. /evidence=ECO:0000255|PROSITE-ProRule:PRU01397	496..514		4/17 (24%)
		Bipartite nuclear localization signal. /evidence=ECO:0000250|UniProtKB:Q6PDM1	505..519		4/38 (11%)
		Sufficient for interaction with MSL3 MRG domain	550..591		11/59 (19%)