DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12316 and MSL1

DIOPT Version :9

Sequence 1:	NP_648752.1	Gene:	CG12316 / 39650	FlyBaseID:	FBgn0036483	Length:	1188	Species:	Drosophila melanogaster
Sequence 2:	NP_001352848.1	Gene:	MSL1 / 339287	HGNCID:	27905	Length:	614	Species:	Homo sapiens

Alignment Length:	726	Identity:	123/726 - (16%)
Similarity:	216/726 - (29%)	Gaps:	269/726 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   487 QTLDDEEQDLV--EEDQYSGAHSHGFFPRSSN--------ASYASGQRTP------------LYH 529
            |.||.|....:  .||:...|.:| |.||...        ||...|...|            |..
Human    21 QRLDYERAAALGGPEDEPGAAEAH-FLPRHRKLKEPGPPLASSQGGSPAPSPAGCGGKGRGLLLP 84

  Fly   530 CRQTSSQNSN---------CSESSLLKKQVTFSPRHLGAATPNAKTGTSKKPSIKQYKPSSSN-- 583
            ......|...         |...:..:..:...|...||       |.|.:|..:...|..:.
Human    85 AGAAPGQQEESWGGSVPLPCPPPATKQAGIGGEPAAAGA-------GCSPRPKYQAVLPIQTGSL 142

  Fly   584 ---ATESQRWKEEHRKASAKMFAKLDAKIKARSEAENVSTSQLTPTTSNASSSTPTKISGTPTRI 645
               |.|...|..:...|::.                       ..|.|:.:...|..:.|.|.
Human   143 VAAAKEPTPWAGDKGGAASP-----------------------AATASDPAGPPPLPLPGPPP-- 182

  Fly   646 RSTQRGQRVALPTPPASTHSSS---------SPCQIRSASTDNHNYNVDSDYSRRCFSKAAGDEV 701
                     ..||..|.|.::|         ||......|                   .|..:.
Human   183 ---------LAPTATAGTLAASEGRWKSMRKSPLGGGGGS-------------------GASSQA 219

  Fly   702 SYYNHLLTLQRENIRRRRLNNQKKKKNRKVSQKVQKKDDKLNMLKQATKRCRKLRALNAKRKNEV 766
            :....:|.||.:.|.:::  .|.:.|.:::.:...::|..|..:::..:|.:.::..|.|.::::
Human   220 ACLKQILLLQLDLIEQQQ--QQLQAKEKEIEELKSERDTLLARIERMERRMQLVKKDNEKERHKL 282

  Fly   767 -----------------------QKLEQDLDTI---------------RK----SAPHKLPIIRL 789
                                   .:|.:...|:               ||    |...|.|:.:|
Human   283 FQGYETEEREETELSEKIKLECQPELSETSQTLPPKPFSCGRSGKGHKRKSPFGSTERKTPVKKL 347

  Fly   790 ----KRCNLKTQKRS-LKAEEAPSVQEDILSMNSDRELQEQKKAQKPKRKRYKKVQKEQENEKYL 849
                .:...||.|.| :|.|...|:.|.:..    |||:.|:..:||:..
Human   348 APEFSKVKTKTPKHSPIKEEPCGSLSETVCK----RELRSQETPEKPRSS--------------- 393

  Fly   850 REQEIIISQSQMVEEDKVEEHHAHEAPSEQQRELDLEHQQFLE--EQLLQEEHQ-----LAMHEE 907
                 :.:..::....|....|    |.|:....::|...:|.  |..|...||     |.:.|
Human   394 -----VDTPPRLSTPQKGPSTH----PKEKAFSSEIEDLPYLSTTEMYLCRWHQPPPSPLPLRE- 448

  Fly   908 EHHQMDDEQESHEVARLLEDQQPAEGTHLHVENEMLAEKEQPLIEDDDQEADDQNQNEHLSDDQQ 972
                 ...::...|||.|.....|..|.:...........:||     ::.:..:..|:|.|...
Human   449 -----SSPKKEETVARCLMPSSVAGETSVLAVPSWRDHSVEPL-----RDPNPSDLLENLDDSVF 503

  Fly   973 QEADQQLSIEQPQEHEENQSLSQDPLDEQCTPTPNGKRRK-------RRRRFKRRCWTHVKNKKK 1030
            .:...:|.:::                         ||||       |.:|..:|....:..||.
Human   504 SKRHAKLELDE-------------------------KRRKRWDIQRIREQRILQRLQLRMYKKKG 543

  Fly  1031 KQWLIDYPLEFEADPALDTPPIQPEPAPDEQQAELVTGPVSESVAEPVAEPVAEPVSEPFAEQIA 1095
            .|         |::|  :.....||  ||:.::.::|                     ||...:|
Human   544 IQ---------ESEP--EVTSFFPE--PDDVESLMIT---------------------PFLPVVA 574

  Fly  1096 --EPIAQPTPE 1104
              .|:.:.||:
Human   575 FGRPLPKLTPQ 585

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12316	NP_648752.1	PHA02666	504..>685	CDD:222914	36/223 (16%)
		GBP_C	<819..947	CDD:303769	24/134 (18%)
		coiled coil	931..943	CDD:293879	2/11 (18%)
		Trypan_PARP	<1026..1130	CDD:114603	16/81 (20%)
MSL1	NP_001352848.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..127		22/113 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	147..217		17/122 (14%)
		Interaction with MSL2	223..237		4/13 (31%)
		PTZ00108	<243..429	CDD:240271	34/213 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	272..420		28/175 (16%)
		Nuclear localization signal. /evidence=ECO:0000250\|UniProtKB:Q6PDM1	317..346		5/28 (18%)
		PEHE	473..591	CDD:405867	29/177 (16%)
		Interaction with KAT8	498..518		5/44 (11%)
		Bipartite nuclear localization signal. /evidence=ECO:0000250\|UniProtKB:Q6PDM1	505..519		4/38 (11%)
		Sufficient for interaction with MSL3 MRG domain	550..591		11/59 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144854
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR21656
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.030