Protein Alignment Cep135 and Cep135

DIOPT Version :8

• Sequence 1: NP_001189108.1
• Gene: Cep135 / 39647
• FlyBaseID: FBgn0036480
• Length: 1065
• Species: Drosophila melanogaster
• Sequence 2: XP_001076228.3
• Gene: Cep135 / 305288
• RGDID: 1310726
• Length: 1140
• Species: Rattus norvegicus
• Alignment Length: 1172
• Identity: 266/1173 (23%)
• Similarity: 507/1173 (43%)
• Gaps: 202/1173 (17%)

  Fly    10 DLRCKLDIMGFTQTLPVLAIPLVQAVFGDLIKTTECLRDTKKKVAELLEEKTCWELGVEPYKCDN 74
            ::|.:||.:|:.|||.|.::|||:.:|.||:.|||.||..:....:..::...::..:||||.:|
  Rat    11 NIRKRLDQLGYRQTLSVDSLPLVEKLFSDLVHTTESLRQCRLSSVKAEKDSANFDFVLEPYKLEN 75

  Fly    75 SRLLAECNELHLQFLRDRE-------DYELRLCESERKIRNLE-LDKQH------LQSHNDGLQR 125
            :||..|.|||:|:.::.||       |.::.|.:|.|:..:|: |:.|:      |:..:.....
  Rat    76 TRLNKENNELYLELMKLREYSDKHIKDLKITLKKSSRETADLKFLNNQYVHKVRLLEKESKAKDE 140

  Fly   126 QLDALLTKQM---VSSVTNKKATAGIGRQTKKPFITTVRSGIAMPTTLGTSSSALKCTKCNAGVF 187
            ::..|..|.:   |.:...:|......||         |..|..|......||        ..|.
  Rat   141 KIQQLQEKNLRAVVQTPGGRKRNIAFRRQ---------RMQIDEPAPPSEVSS--------YPVP 188

  Fly   188 QKTTTTTKDGVTVTQT---SGQEELDKMQNDLTAAGEQLEFFKRKVEARNREIRRLNDMLAGGRP 249
            |.......|.:.|...   ..|||:.::|..|....:.::.:.|::|.|.|||.||:..:.|||.
  Rat   189 QPEDPYIADLLQVADNRIQELQEEVHQLQEKLAQMEKGVQDYSRQIELREREIERLSVAVDGGRS 253

  Fly   250 LAALAKDCCYKD----VGALSQDIDLLQREKSDLMMQVREFQDKMHDAMQRALSSEEDKIKLQTQ 310
            ...|:.:...|.    :..|:..:|.||:...:|..:::|..:.........::......||..:
  Rat   254 PDILSLETRNKTNEKLIAQLNIQVDFLQQANKELERRIQELMETKATVTTEVVNLSNRNEKLCQE 318

  Fly   311 LEELKEAALQVEQQANAEIDAKESELRQLQLELKKKGKDHRLTGGFASNQSDKHNLNERLNLLTR 375
            |.|:.:.|.|:|:.....::..:.||.:.:.|:|:             |.|:..||.|:::.|
  Rat   319 LTEIDQMAQQLERHKEQVLETADRELGEAKKEIKR-------------NLSEMRNLEEKMSKL-- 368

  Fly   376 REEELQATNEKHKKKI-------QKMQAKILELQKELKDQNK--------HSNVTLDEEKIRL-- 423
             :.||..:| |.|:::       ..::..:.:|::|.:..||        ...:||:.|::||
  Rat   369 -QWELDVSN-KEKERLNGELLLKSDLETVVHQLEQEKQRLNKKLQSFAVTERELTLEVERMRLEH 431

  Fly   424 -------------------SSERDFFQKEYLRLM------------------------SKTGSES 445
                               ..|||:::||..:|.                        .|....|
  Rat   432 GIKRRDKSPSRLDTFLKGIEDERDYYKKELEKLQHLIQRRSCSVIYCAREKPPIIKCSEKGDCNS 496

  Fly   446 EIAFLHAQIKSKDE-----------------ELKALRSE------LFHGGKQQFSPQKSVQYETL 487
            :|   |...:.:||                 .:|.|.:|      |:...|::.|..:.....:|
  Rat   497 DI---HLITRERDELQRMLERFEKYMEDIQSNVKLLTAERDRLSVLYKEAKEELSALRQESTGSL 558

  Fly   488 PPPTASSITSTVTSNTSDCVQAAIARVERERDCARTELERVRCERDTLREKQLSTVQLHADELQA 552
            .|           :|...|       :|:|::.|.::|.|:..|::.|||| |..:|    ||..
  Rat   559 AP-----------NNLVSC-------IEKEKERALSDLRRITAEKEALREK-LKNIQ----ELNV 600

  Fly   553 LRLRNEELNDRLRQMERDNRELNSARLPTETNLVLLKEDLLQMR-------QRVASMQTEIDQLK 610
              :...||...:..:...|.:|.:.:...::.::::||.:..:.       |:::.:..:....|
  Rat   601 --VGKSELEKTIEHLTYINHQLENEKYELQSKILIMKETIESLESKSKLQAQKLSHVTGDSSHQK 663

  Fly   611 TENDQITMLNDQNERIIADYQSKLLVAERQRQSADVRASTLDSSRESNRSEVTQLRMDLGALRQT 675
            ||.:.:.::::|.:|.:.|.|.:|.:...:.:||..:...|:...||....:|....:..|:::|
  Rat   664 TEMNSLRIVSEQLQRSLDDCQHRLSIKRGELESAQEQIKALEQKLESLSHRMTMQSEETHAMKKT 728

  Fly   676 YISLEHEKDTLLHQLDTKTERVYKLEYELKDCKEKRNALEQNVKDLEDQLRKLANRNRQRDSELT 740
            ...::.|||.|...:|.|||::..|:..|...::....|:..|.:.|..|.:|......||.|:.
  Rat   729 IGVMDKEKDFLQETVDEKTEKIASLQDSLISKEKAITQLKVTVSECESSLNQLQETLTNRDREIN 793

  Fly   741 ETSTESKTLRQQIVALKASRDEAIAENRRLMDKLSDAQVEARTLQKKLTDSELQVANMKQQLHKY 805
            ....:.....:::..:..||:.:..|||||.|.|:....|.:.:..:|..:..:...||.::|||
  Rat   794 SLRRQLDATHKELDDVGKSREISYKENRRLQDDLATMARENQEISLELEAAVQEKEEMKSRVHKY 858

  Fly   806 VQEVKKAEDLLIQKVSSKFKEKERDDMLDQYHCLTQGQATLEGNNQSLECEAVEFRRQICELECE 870
            :.||.:.|.|:..      ||||..|:||::..|.......|...|..|.|....|.::..::.|
  Rat   859 ITEVSRWESLMAA------KEKENKDLLDRFQMLHNRAEDWEIKAQQAEGENSSVRLELLSIDTE 917

  Fly   871 VHSLKEQLQLRQ-------CALHDMEVQLTAARASVRCLERELENARDDIRVQKVDLEARKELCD 928
            ...|:|:::|.:       .|.|..|.|:::...::..||.||.....:......|:.:.:|||.
  Rat   918 RRHLRERVELLEKEIQEHINAHHAYESQISSMAKAMSQLEEELRRHESEKATVLGDVSSLRELCI 982

  Fly   929 KLDVERSKLNAELNDVNEIRKKLEKQCEKLRDE---LQQSLAINQVTNETTDLMLGRLHNDQQHQ 990
            |||..:..:..:||......::...:.|.::.|   |::.|...:.|..:.:.:|. .:.|::.|
  Rat   983 KLDSGKDIMTHQLNSKGLELERAVAELENVKSESELLKKQLMTERQTINSLESLLA-TNRDKEFQ 1046

  Fly   991 EDDDIRSKHEMDRLQRQLQQTLDQLQEERVRCRHHEE--LAEKWEQQVRD---LRRNLADDRYNQ 1050
            ..   .:.||.|...:.|::.|: |.|.::..:..|.  |..|..|...|   |:|.:::::|.:
  Rat  1047 SH---LTSHEKDTEIQLLKEKLN-LSESKLTTQSRETSMLRTKVTQLQTDYDNLKRLMSNEKYER 1107

  Fly  1051 AR 1052
            .|
  Rat  1108 ER 1109

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cep135	NP_001189108.1	Smc	<203..963	CDD:224117	189/867 (22%)
		DUF342	<302..421	CDD:302792	29/134 (22%)
Cep135	XP_001076228.3	Smc	202..994	CDD:224117	194/899 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
eggNOG	1	0.900				E1_28KKT
Hieranoid	1	1.000
Homologene	1	1.000				H45709
Inparanoid	1	1.050	259	1.000	Inparanoid score	I2992
OMA	1	1.010
OrthoDB	1	1.010				D139407at2759
OrthoFinder	1	1.000				FOG0002578
OrthoInspector	1	1.000				T617522
orthoMCL	1	0.900				OOG5_132847
Panther	1	1.100			LDO	PTHR23159
Phylome	0	0.000	Not matched by this tool.
TreeFam	1	0.960
	11	10.930