Protein Alignment dlp and GPC5

DIOPT Version :10

• Sequence 1: NP_524071.2
• Gene: dlp / 39596
• FlyBaseID: FBgn0041604
• Length: 765
• Species: Drosophila melanogaster
• Sequence 2: NP_004457.1
• Gene: GPC5 / 2262
• HGNCID: 4453
• Length: 572
• Species: Homo sapiens
• Alignment Length: 681
• Identity: 156/681 - (22%)
• Similarity: 277/681 - (40%)
• Gaps: 150/681 - (22%)

  Fly    80 CSAVTHIFQARGIDAIE-IPQKPSNERVLRYCESPSVGTCCTYNMETRMAMQSRQQLEGHTKDQI 143
            |..|..:||.|.:.|:. :|..|.....|:.|.|.. .||||..||.|..:.:||.::...:...
Human    30 CEEVRKLFQWRLLGAVRGLPDSPRAGPDLQVCISKK-PTCCTRKMEERYQIAARQDMQQFLQTSS 93

  Fly   144 SRMSGILGSKATKFKDIFTALLKESRTQFNSMFIRTYGVIYERNSYVFSDLFKELETYFANGRVD 208
            |.:..::...|..|::....|:|::....:.:|..||..:....:....:.|.::..|.....|:
Human    94 STLKFLISRNAAAFQETLETLIKQAENYTSILFCSTYRNMALEAAASVQEFFTDVGLYLFGADVN 158

  Fly   209 LLEVMDKFFNTLYQKMFTVLNTQYTFDEN--YMRCVSEHMKELKPFGDVPDKLSVQIKRSFVATR 271
            ..|.:::||::|:..::..|......|.:  |..|:....:::.|||::|.::..|:.||.:.:|
Human   159 PEEFVNRFFDSLFPLVYNHLINPGVTDSSLEYSECIRMARRDVSPFGNIPQRVMGQMGRSLLPSR 223

  Fly   272 TYGQALTTASEVAKKVLNVRLNADCTGALTKMQHCGACKGYT-EKPCTNYCVNVIKGCLHYQHEF 335
            |:.|||....||......:..:.:|:.||.|||:|..|:|.. .|||..||:||::|||.:..|.
Human   224 TFLQALNLGIEVINTTDYLHFSKECSRALLKMQYCPHCQGLALTKPCMGYCLNVMRGCLAHMAEL 288

  Fly   336 DSEWENFAMAMDKVAERLLGSFNIVMVVEPLNIKISEAIMNFQDSGQDITNRVFQGCGRPKLKKM 400
            :..|..:..:::::::.:.|:::|..|:...::.:::|::....:||.:..:|.:.||||
Human   289 NPHWHAYIRSLEELSDAMHGTYDIGHVLLNFHLLVNDAVLQAHLNGQKLLEQVNRICGRP----- 348

  Fly   401 KRSISPKLQGVQILNARSPVEADTLDIDETLDEAIVLRERRAAEPGSQETSAQQSQEQGVGKSGN 465
                           .|:|.::.....|:            :.|....:|:.:.|:|...
Human   349 ---------------VRTPTQSPRCSFDQ------------SKEKHGMKTTTRNSEETLA----- 381

  Fly   466 GGGGGGGNNRRQQQRRKQQQQRRKQQNNRDDNDDDDNESGGGREPILDRIVRDIRQRVKDYKKFW 530
                    |||::                                    .:..:|.    |:.|:
Human   382 --------NRRKE------------------------------------FINSLRL----YRSFY 398

  Fly   531 SNLPHSVCSNEDIASSSDVDGM-CWNGHTIDRYMHSITTEHGSNPEFTGNP-ASTKQTAQMASQL 593
            ..|...:|:||..|:    ||: ||||..|.:........:|...: :||| ...|....:.:|:
Human   399 GGLADQLCANELAAA----DGLPCWNGEDIVKSYTQRVVGNGIKAQ-SGNPEVKVKGIDPVINQI 458

  Fly   594 SHLKNAIVHLRNAYNGQDVEWSEQEELPYAGSGAG---SGSGSEDDEDDDEGSGLGPFEPSHKPD 655
            ......:|.|....:.:..:|    ||...|||.|   ..||..||||...|||.|        :
Human   459 IDKLKHVVQLLQGRSPKPDKW----ELLQLGSGGGMVEQVSGDCDDEDGCGGSGSG--------E 511

  Fly   656 VERPSVDADNDDDEDAGGRGHMPTHTSRPTSGVDDKNPLIHTTHFDQDHNDLDEDHRQLDEDEDT 720
            |:|                      |.:.|..:.|          |.:.:|:.:.| |.|.....
Human   512 VKR----------------------TLKITDWMPD----------DMNFSDVKQIH-QTDTGSTL 543

  Fly   721 DAGHDGANDNRSSDAPEKMTLRRALVVYLLP 751
            |....|.     :.|.|.||.....||.|||
Human   544 DTTGAGC-----AVATESMTFTLISVVMLLP 569

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dlp	NP_524071.2	Glypican	79..619	CDD:460084	119/544 (22%)
GPC5	NP_004457.1	Glypican	12..569	CDD:460084	154/679 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	355..375		3/31 (10%)