Protein Alignment dlp and GPC4

DIOPT Version :10

• Sequence 1: NP_524071.2
• Gene: dlp / 39596
• FlyBaseID: FBgn0041604
• Length: 765
• Species: Drosophila melanogaster
• Sequence 2: NP_001439.2
• Gene: GPC4 / 2239
• HGNCID: 4452
• Length: 556
• Species: Homo sapiens
• Alignment Length: 599
• Identity: 201/599 - (33%)
• Similarity: 307/599 - (51%)
• Gaps: 99/599 - (16%)

  Fly    77 SPNCSAVTHIFQARGIDAIEIPQKPSNERVLRYCESPSVGTCCTYNMETRMAMQSRQQLEGHTKD 141
            |.:||.|..::.::|.:..:.|....|...|:.|  |...|||:..||.:.::||:...:....:
Human    27 SKSCSEVRRLYVSKGFNKNDAPLHEINGDHLKIC--PQGSTCCSQEMEEKYSLQSKDDFKSVVSE 89

  Fly   142 QISRMSGILGSKATKFKDIFTALLKESRTQFNSMFIRTYGVIYERNSYVFSDLFKELETYFANGR 206
            |.:.:..:..|:..||.:.|..||:.:....|.||::|||.:|.:||.:|.|||.||:.|:..|.
Human    90 QCNHLQAVFASRYKKFDEFFKELLENAEKSLNDMFVKTYGHLYMQNSELFKDLFVELKRYYVVGN 154

  Fly   207 VDLLEVMDKFFNTLYQKMFTVLNTQYTFDENYMRCVSEHMKELKPFGDVPDKLSVQIKRSFVATR 271
            |:|.|:::.|:..|.::||.::|:||.|.:.|:.|||::.::||||||||.||.:|:.|:|||.|
Human   155 VNLEEMLNDFWARLLERMFRLVNSQYHFTDEYLECVSKYTEQLKPFGDVPRKLKLQVTRAFVAAR 219

  Fly   272 TYGQALTTASEVAKKVLNVRLNADCTGALTKMQHCGACKG-YTEKPCTNYCVNVIKGCLHYQHEF 335
            |:.|.|..|.:|..||..|...|.||.||.||.:|..|:| .|.|||.|||.|:::|||..|.:.
Human   220 TFAQGLAVAGDVVSKVSVVNPTAQCTHALLKMIYCSHCRGLVTVKPCYNYCSNIMRGCLANQGDL 284

  Fly   336 DSEWENFAMAMDKVAERLLGSFNIVMVVEPLNIKISEAIMNFQDSGQDITNRVFQGCGRPKLKKM 400
            |.||.||..||..|||||.|.|||..|::|:::|||:||||.||:...::.:||||||.||
Human   285 DFEWNNFIDAMLMVAERLEGPFNIESVMDPIDVKISDAIMNMQDNSVQVSQKVFQGCGPPK---- 345

  Fly   401 KRSISPKLQGVQILNARSPVEADTLDIDETLDEAIVLRERRAAEPGSQETSAQQSQEQGVGKSGN 465
                              |:.|..  |..::.|:......|...|..:.|:|       .|.|
Human   346 ------------------PLPAGR--ISRSISESAFSARFRPHHPEERPTTA-------AGTS-- 381

  Fly   466 GGGGGGGNNRRQQQRRKQQQQRRKQQNNRDDNDDDDNESGGGREPILDRIVRDIRQRVKDYKKFW 530
                                                          |||:|.|:::::|..||||
Human   382 ----------------------------------------------LDRLVTDVKEKLKQAKKFW 400

  Fly   531 SNLPHSVCSNEDIASSSDVDGMCWNGHTIDRYMHSIT----TEHGSNPEFTGNPASTKQTAQMAS 591
            |:||.:||::|.:|:.:..:..||||....||:.::|    ...|:|||...:  ::|....:..
Human   401 SSLPSNVCNDERMAAGNGNEDDCWNGKGKSRYLFAVTGNGLANQGNNPEVQVD--TSKPDILILR 463

  Fly   592 QLSHLKNAIVHLRNAYNGQDVEWSEQEELPYAGSGAGSGSG-------SEDDEDDDEGSGLGPFE 649
            |:..|:.....::|||||.||::.:..:   ..||.|||||       ||.|.:..:.:|....|
Human   464 QIMALRVMTSKMKNAYNGNDVDFFDISD---ESSGEGSGSGCEYQQCPSEFDYNATDHAGKSANE 525

  Fly   650 PSHKPDVERPSVDA 663
            .:....| ||...|
Human   526 KADSAGV-RPGAQA 538

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dlp	NP_524071.2	Glypican	79..619	CDD:460084	184/544 (34%)
GPC4	NP_001439.2	Glypican	26..551	CDD:460084	201/599 (34%)