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Protein Alignment CG10222 and GPN2

DIOPT Version :9

Sequence 1:	NP_648641.2	Gene:	CG10222 / 39504	FlyBaseID:	FBgn0036356	Length:	307	Species:	Drosophila melanogaster
Sequence 2:	NP_060536.3	Gene:	GPN2 / 54707	HGNCID:	25513	Length:	310	Species:	Homo sapiens

Alignment Length:	287	Identity:	147/287 - (51%)
Similarity:	201/287 - (70%)	Gaps:	10/287 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 PTQATVENPRYGQLIIGPPGSGKTTYCGEALKFYRELGRQVGVVNLDPANENMSYEPVLSVMELI 70
            ||.|      :||.:||||||||||||....:|.|.|||:|.|||||||||.:.||..:.|.||:
Human     6 PTTA------FGQAVIGPPGSGKTTYCLGMSEFLRALGRRVAVVNLDPANEGLPYECAVDVGELV 64

  Fly    71 TVEDCMEHLKLGPNGALMHCAEYLADHLEDWLLPALRKLSATYNYFLFDCPGQVELYTHHNAMAR 135
            .:.|.|:.|:|||||.|::|.|||..:| |||...|..|..  :||||||||||||.|||.|:..
Human    65 GLGDVMDALRLGPNGGLLYCMEYLEANL-DWLRAKLDPLRG--HYFLFDCPGQVELCTHHGALRS 126

  Fly   136 IFERLERERYSLVTVNLIDSHYCSEPAKFIATLLMALNTMLRMSLPHVNVLSKADLLKKHETKLH 200
            ||.::.:....|..|:|:|||||::|||||:.|..:|.|||.:.|||:|:|||.||: :|..||.
Human   127 IFSQMAQWDLRLTAVHLVDSHYCTDPAKFISVLCTSLATMLHVELPHINLLSKMDLI-EHYGKLA 190

  Fly   201 FNVDYYTDVLDLKYLLDKLDDDPAMRKYRKLNAAICSMVEDYALVSFQLLDVFSTDSMLRLRNHI 265
            ||:||||:||||.||||.|..||..|.||:||..:..::|||:||||..|::...:|:.|:...:
Human   191 FNLDYYTEVLDLSYLLDHLASDPFFRHYRQLNEKLVQLIEDYSLVSFIPLNIQDKESIQRVLQAV 255

  Fly   266 DKANGYVYKAGEEQTVNSLLACAVGAE 292
            ||||||.::|.|::::.::::.|:||:
Human   256 DKANGYCFRAQEQRSLEAMMSAAMGAD 282

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10222	NP_648641.2	GPN2	16..267	CDD:349780	133/250 (53%)
GPN2	NP_060536.3	GPN2	10..257	CDD:349780	133/250 (53%)
GPN2	NP_060536.3	Gly-Pro-Asn (GPN)-loop, involved in dimer interface. /evidence=ECO:0000250\|UniProtKB:Q9UYR9	76..78		1/1 (100%)

Information from Original Tools:

Software error:

Can't use an undefined value as an ARRAY reference at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 1034.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-
Domainoid	1	1.000	-	-
eggNOG	1	0.900	-	-
Hieranoid	1	1.000	-	-