Protein Alignment trn and Lingo4

DIOPT Version :10

• Sequence 1: NP_001261796.1
• Gene: trn / 39491
• FlyBaseID: FBgn0010452
• Length: 751
• Species: Drosophila melanogaster
• Sequence 2: NP_001102659.1
• Gene: Lingo4 / 499668
• RGDID: 1562025
• Length: 618
• Species: Rattus norvegicus
• Alignment Length: 459
• Identity: 134/459 - (29%)
• Similarity: 201/459 - (43%)
• Gaps: 84/459 - (18%)

  Fly    12 IWCILASIGVEPAAGLANCPPGCQCDDNTLVVQCGEGQLDVLPIALNPSIQRLVIKSNKIKTID- 75
            :|..|..:.:.|...:::||..|.|...|..|.|...:||.:|..|....:.|.:..|::..:.
  Rat    38 LWSPLLFLLLLPGGSISSCPTLCDCTSQTRAVLCAHRRLDTVPGGLPLDTEVLDLSGNRLWGLQR 102

  Fly    76 SSIQFYAELTFLDLSSNHLMTIPQRTFAYQKKLQEVHLNHNKIGQISNKTFIGLSAVTVLNLRGN 140
            ..:....:|..||||.|.|.|:....|...:.|..:.|..|::..:....|.||||:|:|:||.|
  Rat   103 GMLSRLGQLQELDLSYNQLSTLEPGAFHGLQSLLTLRLQGNRLRIVGPGIFSGLSALTLLDLRLN 167

  Fly   141 QISELHQGTFTPLLKIEELNLGENRIGYLDPKAFDGLSQLRILYLDDNALTTVPDPVIFQAMPSL 205
            ||.....|.|..|..:::|.:|:|.:.::.|.||.||::|..:.|:...|:|||...:.| :|:|
  Rat   168 QIVLFLDGAFGELGSLQQLEVGDNHLVFVAPGAFSGLAKLSTITLERCNLSTVPGLALAQ-LPAL 231

  Fly   206 AELFL--------------GMNTLQSIQADAFQDLKGLTRLELKGASLR-------NISHDSFLG 249
            ..|.|              |:..|:.::...:..|:.|....|.|.:|.       |:|...|..
  Rat   232 VALRLRELDIERLPSGALRGLGQLKELEIHHWPSLEALDPGSLVGLNLSSLAITHCNLSSVPFQA 296

  Fly   250 LQE---LRILDLSDNRLDRIPSVGLSKLVRLEQLSLGQNDFEVISEGAFMGLKQLKRLEVNGALR 311
            |..   |::||||.|.:..||:..||.||||::|.|.......|:..||.||.
  Rat   297 LHHLSFLQVLDLSQNPISAIPARRLSPLVRLQELRLSGACLTSIAAHAFHGLT------------ 349

  Fly   312 LKRVMTGAFSDNGNLEYLNLSSNKMLLEVQEGALSGLSQLKHVVLKANALTSLAEGLFPWKD-LQ 375
                   ||.               ||:|.:                |||.:|.|..||..| |.
  Rat   350 -------AFH---------------LLDVAD----------------NALQTLEETAFPSPDKLV 376

  Fly   376 TLDLSENPLSCDCRVMWLHNLLVAKNASQDDVSELLCEFPERLRGESLRH----LNPAMMGCTHA 436
            ||.||.|||:||||::||..|   :.......|...|..|:.::|::||.    |.|....|..|
  Rat   377 TLRLSGNPLTCDCRLLWLLRL---RRRLDFGTSPPACAGPQHVQGKNLREFSDILPPGHFTCKPA 438

  Fly   437 DPRK 440
            ..||
  Rat   439 LIRK 442

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
trn	NP_001261796.1	leucine-rich repeat	62..80	CDD:275380	2/18 (11%)
		LRR	82..406	CDD:443914	106/348 (30%)
		leucine-rich repeat	84..107	CDD:275380	9/22 (41%)
		leucine-rich repeat	108..131	CDD:275380	6/22 (27%)
		leucine-rich repeat	132..155	CDD:275380	10/22 (45%)
		leucine-rich repeat	156..179	CDD:275380	8/22 (36%)
		leucine-rich repeat	180..204	CDD:275380	7/23 (30%)
		leucine-rich repeat	205..228	CDD:275380	6/36 (17%)
		leucine-rich repeat	229..252	CDD:275380	8/29 (28%)
		leucine-rich repeat	253..276	CDD:275380	11/22 (50%)
		leucine-rich repeat	277..300	CDD:275380	8/22 (36%)
		leucine-rich repeat	301..322	CDD:275380	2/20 (10%)
		leucine-rich repeat	326..350	CDD:275380	3/23 (13%)
		leucine-rich repeat	351..373	CDD:275380	7/21 (33%)
		LRRCT	382..434	CDD:214507	18/55 (33%)
Lingo4	NP_001102659.1	leucine-rich repeat	87..110	CDD:275380	2/22 (9%)
		LRR	<88..441	CDD:443914	118/406 (29%)
		leucine-rich repeat	111..134	CDD:275380	9/22 (41%)
		leucine-rich repeat	135..158	CDD:275380	6/22 (27%)
		leucine-rich repeat	159..182	CDD:275380	10/22 (45%)
		leucine-rich repeat	183..206	CDD:275380	8/22 (36%)
		leucine-rich repeat	207..230	CDD:275380	7/23 (30%)
		leucine-rich repeat	231..254	CDD:275380	4/22 (18%)
		leucine-rich repeat	255..302	CDD:275380	10/46 (22%)
		leucine-rich repeat	303..326	CDD:275380	11/22 (50%)
		leucine-rich repeat	327..348	CDD:275380	6/20 (30%)
		leucine-rich repeat	351..374	CDD:275380	11/53 (21%)
		IG_like	445..526	CDD:214653
		Ig strand B	456..460	CDD:409353
		Ig strand C	469..473	CDD:409353
		Ig strand E	492..496	CDD:409353
		Ig strand F	506..511	CDD:409353
		Ig strand G	519..522	CDD:409353