Protein Alignment: LDLR and arr

• Sequence 1: NP_000518.1
• Gene: LDLR
• HGNCID: 6547
• Length: 860
• Species: Homo sapiens
• Sequence 2: NP_524737.2
• Gene: arr
• FlyBaseID: FBgn0000119
• Length: 1678
• Species: Drosophila melanogaster
• Alignment Length: 458
• Identity: 136/459 (30%)
• Similarity: 219/459 (48%)
• Gaps: 83/459 (18%)

Human   288 ECITLDKVCNMARDCRDWSDEPIKECGTNECLDNNGGCSHVC----NDLKIGYECLCPDGFQLVA 348
            |.|...|..|   ..|.| |..::....|.|..|||.|||:|    |..  |:.|.||.|.:|::
  Fly   335 ELIDTPKAPN---SVRAW-DPSLQPYEDNPCAHNNGNCSHLCLLATNSQ--GFSCACPTGVKLIS 393

Human   349 QRRCEDIDECQDPDTCSQLCVNLEGGYKCQCEEGFQLDPHTKACKAVGSIAYLFFTNRHEVRKMT 413
            ...|                                         |.||...:|...|.::.|::
  Fly   394 ANTC-----------------------------------------ANGSQEMMFIVQRTQISKIS 417

Human   414 LDRSEYTSLIP----NLRNVVALDTEVASNRIYWSDLSQRMICSTQLDRAH----GVSSYDTVIS 470
            ||..:|| :.|    .::..:|:|.:.....|||||:.     :..:.|||    ||:.:   ::
  Fly   418 LDSPDYT-IFPLPLGKVKYAIAIDYDPVEEHIYWSDVE-----TYTIKRAHADGTGVTDF---VT 473

Human   471 RDIQAPDGLAVDWIHSNIYWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTD 535
            .:::.|||||:||:..|:||||:|...:.|....|..||.|..|:..:||||.|.|..|:|:|:|
  Fly   474 SEVRHPDGLALDWLARNLYWTDTVTDRIEVCRLDGTARKVLIYEHLEEPRAIAVAPSLGWMFWSD 538

Human   536 WG-TPAKIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNRKTIL 599
            |. ...|:::..|:|.:...||:||:.|||||.||:.:..:||.|.|...|...:::|..|:.::
  Fly   539 WNERKPKVERASLDGSERVVLVSENLGWPNGIALDIEAKAIYWCDGKTDKIEVANMDGSGRRVVI 603

Human   600 EDEKRLAHPFSLAVFEDKVFWTDIINEAIFSANRLTGSDVNLLAENLLSPEDMVL-FHNLTQPRG 663
            .|  .|.|.|.|::.:|.::|||....:|..|:::||::..::.:..  |:.|.| ...|.:.||
  Fly   604 SD--NLKHLFGLSILDDYLYWTDWQRRSIDRAHKITGNNRIVVVDQY--PDLMGLKVTRLREVRG 664

Human   664 VNWCERTTLSNGGCQYLCLPAPQINPHSPKFTCACPDGMLLARDMRSCLTEAEAAVATQETSTVR 728
            .|.|   .:.||||.:|||..|:      .:.|.|.....||.|.|:|:..|...:.:::....|
  Fly   665 QNAC---AVRNGGCSHLCLNRPR------DYVCRCAIDYELANDKRTCVVPAAFLLFSRQEHIGR 720

Human   729 LKV 731
            :.:
  Fly   721 ISI 723

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LDLR	NP_000518.1	Ldl_recept_a	25..58	CDD:278486
		Ldl_recept_a	66..104	CDD:278486
		Ldl_recept_a	107..143	CDD:278486
		Ldl_recept_a	147..179	CDD:278486
		Ldl_recept_a	195..231	CDD:278486
		Ldl_recept_a	235..270	CDD:278486
		LDLa	278..308	CDD:294076	7/20 (35%)
		FXa_inhibition	318..>346	CDD:291342	14/32 (44%)
		EGF_CA	354..388	CDD:214542	0/34 (0%)
		LDL-receptor class B 1	397..438		11/45 (24%)
		LY	419..457	CDD:214531	10/42 (24%)
		LDL-receptor class B 2	439..485		17/50 (34%)
		Ldl_recept_b	439..482	CDD:278487	15/47 (32%)
		LDL-receptor class B 3	486..528		18/42 (43%)
		Ldl_recept_b	487..525	CDD:278487	17/38 (45%)
		LDL-receptor class B 4	529..572		19/44 (43%)
		Ldl_recept_b	529..569	CDD:278487	18/41 (44%)
		LY	553..595	CDD:214531	17/42 (40%)
		LDL-receptor class B 5	573..615		12/42 (29%)
		LDL-receptor class B 6	616..658		11/43 (26%)
		Ldl_recept_b	616..655	CDD:278487	11/40 (28%)
		FXa_inhibition	671..711	CDD:291342	14/40 (35%)
		Clustered O-linked oligosaccharides	721..768		1/12 (8%)
		Required for MYLIP-triggered down-regulation of LDLR. {ECO:0000269|PubMed:19520913}	811..860
		NPXY motif. {ECO:0000269|PubMed:22509010}	823..828
arr	NP_524737.2	LY	162..201	CDD:214531
		NHL	168..503	CDD:302697	60/224 (27%)
		NHL repeat	172..237	CDD:271320
		LY	252..293	CDD:214531
		NHL repeat	261..298	CDD:271320
		NHL repeat	303..339	CDD:271320	2/4 (50%)
		NHL repeat	341..419	CDD:271320	29/125 (23%)
		NHL repeat	428..476	CDD:271320	12/56 (21%)
		LY	472..511	CDD:214531	15/39 (38%)
		NHL repeat	477..503	CDD:271320	13/26 (50%)
		Ldl_recept_b	534..573	CDD:278487	17/39 (44%)
		LY	558..599	CDD:214531	17/41 (41%)
		LY	600..641	CDD:214531	13/43 (30%)
		FXa_inhibition	668..703	CDD:291342	15/44 (34%)
		LY	739..773	CDD:214531
		LY	776..818	CDD:214531
		LY	819..860	CDD:214531
		FXa_inhibition	973..1010	CDD:291342
		LY	1122..1164	CDD:214531
		FXa_inhibition	1273..1313	CDD:291342
		LDLa	1319..1362	CDD:238060
		LDLa	1365..1399	CDD:238060
		LDLa	1399..1433	CDD:197566

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
eggNOG	1	0.900				E1_KOG1215
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900