| Sequence 1: | NP_000518.1 | Gene: | LDLR | HGNCID: | 6547 | Length: | 860 | Species: | Homo sapiens |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_001097928.1 | Gene: | LpR2 | FlyBaseID: | FBgn0051092 | Length: | 1064 | Species: | Drosophila melanogaster |
| Alignment Length: | 849 | Identity: | 336/850 (40%) |
|---|---|---|---|
| Similarity: | 468/850 (55%) | Gaps: | 68/850 (8%) |
|
Human 27 CERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCLSVTCKSGDFSCGGRVNRCIPQFWRCDG 91
Human 92 QVDCDNGSDEQGCPPKTCSQDEFRCHDGKCISRQFVCDSDRDCLDGSDEASC-PVLTCGPASFQC 155
Human 156 NSSTCIPQLWACDNDPDCEDGSDEWPQRCR-GLYVFQGDSSPCSAFEFHCLSG-ECIHSSWRCDG 218
Human 219 GPDCKDKSDE--ENCAVATCRPDEFQCSDGNCIHGSRQCDREYDCKDMSDEVGC-VNVT--LCEG 278
Human 279 PNKFKCHSGECITLDKVCNMARDCRDWSDEPIKECGTNECLDNNGGCSHVCNDLKIGYECLCPDG 343
Human 344 FQLVA-QRRCEDIDECQDPDTCSQLCVNLEGGYKCQCEEGFQ--LDPHTKACKAVGSIAYLFFTN 405
Human 406 RHEVRKMTLDRSEYTSLIPNLRNVVALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVIS 470
Human 471 RDIQAPDGLAVDWIHSNIYWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTD 535
Human 536 WGTPAKIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNRKTILE 600
Human 601 DEKRLAHPFSLAVFEDKVFWTDIINEAIFSANRLTGSDVNLLAENLLSPEDMV--LFHNLTQPRG 663
Human 664 VNWCERTTLSNGGCQYLCLPAPQINPHSPKFTCACPDGMLLARDMRSCLTE-----------AEA 717
Human 718 AVATQETSTVRLK---VSSTAVRTQHTTTRPVPDTSRLPGATPGLTTVEIVTMSHQALGDVAGRG 779
Human 780 NEKKPSSVRALSIVLPIVLLVF-LCLGVFLLWKNWRLKNINSINFDNPVYQKTTEDEVHICHNQD 843
Human 844 GYSY 847 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| LDLR | NP_000518.1 | Ldl_recept_a | 25..58 | CDD:278486 | 16/31 (52%) |
| Ldl_recept_a | 66..104 | CDD:278486 | 16/38 (42%) | ||
| Ldl_recept_a | 107..143 | CDD:278486 | 20/36 (56%) | ||
| Ldl_recept_a | 147..179 | CDD:278486 | 16/32 (50%) | ||
| Ldl_recept_a | 195..231 | CDD:278486 | 18/39 (46%) | ||
| Ldl_recept_a | 235..270 | CDD:278486 | 18/35 (51%) | ||
| LDLa | 278..308 | CDD:294076 | 12/30 (40%) | ||
| FXa_inhibition | 318..>346 | CDD:291342 | 14/28 (50%) | ||
| EGF_CA | 354..388 | CDD:214542 | 19/36 (53%) | ||
| LDL-receptor class B 1 | 397..438 | 15/41 (37%) | |||
| LY | 419..457 | CDD:214531 | 10/38 (26%) | ||
| LDL-receptor class B 2 | 439..485 | 15/46 (33%) | |||
| Ldl_recept_b | 439..482 | CDD:278487 | 12/43 (28%) | ||
| LDL-receptor class B 3 | 486..528 | 12/42 (29%) | |||
| Ldl_recept_b | 487..525 | CDD:278487 | 10/38 (26%) | ||
| LDL-receptor class B 4 | 529..572 | 20/43 (47%) | |||
| Ldl_recept_b | 529..569 | CDD:278487 | 18/40 (45%) | ||
| LY | 553..595 | CDD:214531 | 22/42 (52%) | ||
| LDL-receptor class B 5 | 573..615 | 20/42 (48%) | |||
| LDL-receptor class B 6 | 616..658 | 15/44 (34%) | |||
| Ldl_recept_b | 616..655 | CDD:278487 | 14/41 (34%) | ||
| FXa_inhibition | 671..711 | CDD:291342 | 20/40 (50%) | ||
| Clustered O-linked oligosaccharides | 721..768 | 12/50 (24%) | |||
| Required for MYLIP-triggered down-regulation of LDLR. {ECO:0000269|PubMed:19520913} | 811..860 | 15/38 (39%) | |||
| NPXY motif. {ECO:0000269|PubMed:22509010} | 823..828 | 4/5 (80%) | |||
| LpR2 | NP_001097928.1 | LDLa | 193..224 | CDD:197566 | |
| LDLa | 235..267 | CDD:197566 | 16/31 (52%) | ||
| LDLa | 277..313 | CDD:238060 | 15/36 (42%) | ||
| LDLa | 356..388 | CDD:197566 | 16/32 (50%) | ||
| LDLa | 400..432 | CDD:197566 | 16/32 (50%) | ||
| LDLa | 442..476 | CDD:238060 | 18/34 (53%) | ||
| LDLa | 484..517 | CDD:197566 | 13/33 (39%) | ||
| FXa_inhibition | 527..562 | CDD:291342 | 17/35 (49%) | ||
| EGF_CA | 564..594 | CDD:214542 | 18/30 (60%) | ||
| LY | 675..715 | CDD:214531 | 14/40 (35%) | ||
| LY | 717..760 | CDD:214531 | 17/43 (40%) | ||
| LY | 763..803 | CDD:214531 | 22/40 (55%) | ||
| FXa_inhibition | 877..918 | CDD:291342 | 21/44 (48%) | ||
| Blue background indicates that the domain is not in the aligned region. | |||||
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 0 | 0.000 | Not matched by this tool. | |||
| eggNOG | 1 | 0.900 | E1_KOG1215 | |||
| Hieranoid | 1 | 1.000 | ||||
| Homologene | 0 | 0.000 | Not matched by this tool. | |||
| Inparanoid | 1 | 1.050 | 713 | 1.000 | Inparanoid score | I631 |
| Isobase | 0 | 0.000 | Not matched by this tool. | |||
| OMA | 1 | 1.010 | ||||
| OrthoDB | 1 | 1.010 | D179614at33208 | |||
| OrthoFinder | 1 | 1.000 | FOG0000315 | |||
| OrthoInspector | 1 | 1.000 | T130091 | |||
| orthoMCL | 1 | 0.900 | OOG5_130540 | |||
| Panther | 1 | 1.100 | O | PTHR24270 | ||
| Phylome | 1 | 0.910 | 0.857 | Consistency score | ||
| RoundUp | 1 | 1.030 | avgDist | Average_Evolutionary_Distance | R7933 | |
| TreeFam | 0 | 0.000 | Not matched by this tool. | |||
| User_Submission | 0 | 0.000 | Not matched by this tool. | |||
| 11 | 10.910 | |||||