Protein Alignment LDLR and Culd

DIOPT Version :10

• Sequence 1: NP_000518.1
• Gene: LDLR / 3949
• HGNCID: 6547
• Length: 860
• Species: Homo sapiens
• Sequence 2: NP_729364.1
• Gene: Culd / 38946
• FlyBaseID: FBgn0035880
• Length: 965
• Species: Drosophila melanogaster
• Alignment Length: 34
• Identity: 16/34 - (47%)
• Similarity: 21/34 - (61%)
• Gaps: 1/34 - (2%)

Human    30 NEFQCQDGKCISYKWVCDGSAECQDGSDESQETC 63
            :||.|.:..|||.:..|||...|.||||| .::|
  Fly   442 SEFLCGNNHCISIRLHCDGFDHCGDGSDE-PDSC 474

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LDLR	NP_000518.1	Ldl_recept_a	25..58	CDD:395011	13/27 (48%)
		Ldl_recept_a	66..104	CDD:395011
		Ldl_recept_a	107..143	CDD:395011
		Binding to Getah virus E1-E2 spike glycoproteins. /evidence=ECO:0000269|PubMed:38245515	146..233
		Ldl_recept_a	147..179	CDD:395011
		Ldl_recept_a	195..231	CDD:395011
		Ldl_recept_a	235..270	CDD:395011
		Ldl_recept_a	278..308	CDD:395011
		FXa_inhibition	318..>346	CDD:464251
		EGF_CA	354..388	CDD:214542
		LDL-receptor class B 1	397..438
		LY	419..457	CDD:214531
		LDL-receptor class B 2	439..485
		Ldl_recept_b	439..483	CDD:459654
		LDL-receptor class B 3	486..528
		Ldl_recept_b	487..526	CDD:459654
		LDL-receptor class B 4	529..572
		Ldl_recept_b	529..569	CDD:459654
		LY	553..595	CDD:214531
		LDL-receptor class B 5	573..615
		LDL-receptor class B 6	616..658
		Ldl_recept_b	616..656	CDD:459654
		FXa_inhibition	671..711	CDD:464251
		Clustered O-linked oligosaccharides	721..768
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	734..755
		Required for MYLIP-triggered down-regulation of LDLR. /evidence=ECO:0000269|PubMed:19520913	811..860
		NPXY motif. /evidence=ECO:0000269|PubMed:22509010	823..828
Culd	NP_729364.1	CUB	200..298	CDD:238001
		LDLa	442..472	CDD:238060	15/30 (50%)