DRSC/TRiP Functional Genomics Resources

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Protein Alignment: LDLR and CG6553

Sequence 1:NP_000518.1 Gene:LDLR HGNCID:6547 Length:860 Species:Homo sapiens
Sequence 2:NP_610911.1 Gene:CG6553 FlyBaseID:FBgn0033880 Length:319 Species:Drosophila melanogaster

Alignment Length:268 Identity:74/269 (28%)
Similarity:100/269 (37%) Gaps:62/269 (23%)


Human   115 RCHDGKCISRQFVCDSDRDCLDGSDE--ASCPVLTCGPASFQCNSSTCIPQLWACDNDPDCEDGS 177
            ||..|.||....:||...:|||||||  |.|..:.|...:|:|:...||.....||...||.|||
  Fly    35 RCGGGDCIQLDQLCDGSANCLDGSDE
TVAMCEKVWCPGYAFRCSYGACIASTAVCDGVQDCVDGS 99

Human   178 DEWPQRCRGLYVFQGDSSPCSAFEFHCLSGECIHSSWRCDGGPDCKDKSDE-----ENCAVATCR 237
            ||....||.    |...:.|..:|.:|.||:|:..|..|||..||:|..||     |...:.|..
  Fly   100 DE
QGWLCRA----QMQQANCDNWEMYCSSGQCMTYSKLCDGIRDCRDGDDELESLCEGVTIPTTT 160

Human   238 -PDEFQCSDGNCIHG-------SRQCDREYDCKDMSDEVGCVNVTLCEGPNKFKCHSGECITLDK 294
             ......:..:.||.       :|:..|                     ||..: .:|||:....
  Fly   161 VSSTTSTTTESSIHRITPTVPVTRKASR---------------------PNPLQ-ENGECVVPQL 203

Human   295 VCNMARDCRDWSDEPIKECGTNECLDNNGGCSHVCNDLKIGYECLCPDGFQLVAQRRCED----- 354
            ...|.:...|    .|...|           |.|.|..:|.|:|......:...|..|:|     
  Fly   204 PNVMVKHFTD----AILTVG-----------SRVANGTRIYYDCPAEHRLKGENQNICQDALWAR 253

Human   355 -IDECQDP 361
             ...|:.|
  Fly   254 KFPYCETP 261

Known Domains:


GeneSequenceDomainRegion External IDIdentity
LDLRNP_000518.1 Ldl_recept_a 25..58 CDD:278486
Ldl_recept_a 66..104 CDD:278486
Ldl_recept_a 107..143 CDD:278486 15/30 (50%)
Ldl_recept_a 147..179 CDD:278486 13/32 (41%)
Ldl_recept_a 195..231 CDD:278486 16/41 (39%)
Ldl_recept_a 235..270 CDD:278486 5/43 (12%)
LDLa 278..308 CDD:294076 7/30 (23%)
FXa_inhibition 318..>346 CDD:291342 6/28 (21%)
EGF_CA 354..388 CDD:214542 3/15 (20%)
LDL-receptor class B 1 397..438
LY 419..457 CDD:214531
LDL-receptor class B 2 439..485
Ldl_recept_b 439..482 CDD:278487
LDL-receptor class B 3 486..528
Ldl_recept_b 487..525 CDD:278487
LDL-receptor class B 4 529..572
Ldl_recept_b 529..569 CDD:278487
LY 553..595 CDD:214531
LDL-receptor class B 5 573..615
LDL-receptor class B 6 616..658
Ldl_recept_b 616..655 CDD:278487
FXa_inhibition 671..711 CDD:291342
Clustered O-linked oligosaccharides 721..768
Required for MYLIP-triggered down-regulation of LDLR. {ECO:0000269|PubMed:19520913} 811..860
NPXY motif. {ECO:0000269|PubMed:22509010} 823..828
CG6553NP_610911.1 LDLa 34..60 CDD:197566 13/25 (52%)
LDLa 70..101 CDD:197566 13/31 (42%)
LDLa 115..146 CDD:197566 14/31 (45%)
Frag1 <260..>303 CDD:287278 1/3 (33%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
eggNOG 1 0.900 E1_KOG1215
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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