| Sequence 1: | NP_000518.1 | Gene: | LDLR | HGNCID: | 6547 | Length: | 860 | Species: | Homo sapiens |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_996433.1 | Gene: | yl | FlyBaseID: | FBgn0004649 | Length: | 1984 | Species: | Drosophila melanogaster |
| Alignment Length: | 932 | Identity: | 274/933 (29%) |
|---|---|---|---|
| Similarity: | 432/933 (46%) | Gaps: | 206/933 (22%) |
|
Human 12 VALLL---AAAGTAVG------DRCERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCLSVT 67
Human 68 CKSGDFSCGGRVNRCIPQFWRCDGQVDCDNGSDEQGCPPKTCSQDEFRCHDGKCISRQFVCDSDR 132
Human 133 DCLDGSDEASCPVLTCGPASFQCNSSTCIPQLWACDNDPDCEDGSDEWPQRCRGLYVFQGDSS-- 195
Human 196 --PCSAFEFHCLSGE-CIHSSWRCDGGPDCKDKSDE-ENC--AVATCRPDEFQCSDGNCIHGSR- 253
Human 254 QCDREYDCKDMSDEVGCVNVTLCE-GPNKFKCHSGE-CITLDKVCNMARDCRDWSDE-------P 309
Human 310 IKECGTNECLDNNGGCSHVCNDLKIGYECLCPDGFQLVA-QRRCEDIDECQD-PDTCSQLCVNLE 372
Human 373 GGYKCQCEEGFQLDPHTKACKAV--GS---IAYLFFTNRHEVRKMTLD----RSEYTSLIPNLRN 428
Human 429 VVALDTEVASNRIYWSDLSQRMICSTQLDRAHG-VSSYDTVISRDIQAPDGLAVDWIHSNIYWTD 492
Human 493 SVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWGTPAKIKKGGLNGVDIYSLVT 557
Human 558 ENIQWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNRKTILEDEKRLAHPFSLAVFEDKVFWTD 622
Human 623 IINEAIFSANRLTGSDVNLLAENLLSPEDMVLFHNLTQPRGVNWCERTTLSNGGCQYLCLPA-PQ 686
Human 687 INPHSPKFTCACPDGMLLARDMRSCLTEAEAAVATQETSTVRLKVSSTAV-RTQHTTTRPVPDT- 749
Human 750 -----SRLPGA-----TPGLTTVEIVTMSHQA-------LGDVAGRG----------NEKKPSSV 787
Human 788 RALSI--------------VLPIVLLVFLCLG-VFLLWKNWRLKNINSINFDNPVYQKTTEDEVH 837
Human 838 ICHNQDGYSYPSRQMVSLEDDV 859 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| LDLR | NP_000518.1 | Ldl_recept_a | 25..58 | CDD:278486 | 16/33 (48%) |
| Ldl_recept_a | 66..104 | CDD:278486 | 5/38 (13%) | ||
| Ldl_recept_a | 107..143 | CDD:278486 | 9/36 (25%) | ||
| Ldl_recept_a | 147..179 | CDD:278486 | 0/32 (0%) | ||
| Ldl_recept_a | 195..231 | CDD:278486 | 18/42 (43%) | ||
| Ldl_recept_a | 235..270 | CDD:278486 | 14/36 (39%) | ||
| LDLa | 278..308 | CDD:294076 | 14/31 (45%) | ||
| FXa_inhibition | 318..>346 | CDD:291342 | 10/28 (36%) | ||
| EGF_CA | 354..388 | CDD:214542 | 18/35 (51%) | ||
| LDL-receptor class B 1 | 397..438 | 9/48 (19%) | |||
| LY | 419..457 | CDD:214531 | 6/38 (16%) | ||
| LDL-receptor class B 2 | 439..485 | 13/47 (28%) | |||
| Ldl_recept_b | 439..482 | CDD:278487 | 11/44 (25%) | ||
| LDL-receptor class B 3 | 486..528 | 11/42 (26%) | |||
| Ldl_recept_b | 487..525 | CDD:278487 | 10/38 (26%) | ||
| LDL-receptor class B 4 | 529..572 | 19/43 (44%) | |||
| Ldl_recept_b | 529..569 | CDD:278487 | 18/40 (45%) | ||
| LY | 553..595 | CDD:214531 | 19/42 (45%) | ||
| LDL-receptor class B 5 | 573..615 | 18/42 (43%) | |||
| LDL-receptor class B 6 | 616..658 | 8/42 (19%) | |||
| Ldl_recept_b | 616..655 | CDD:278487 | 7/39 (18%) | ||
| FXa_inhibition | 671..711 | CDD:291342 | 21/41 (51%) | ||
| Clustered O-linked oligosaccharides | 721..768 | 10/59 (17%) | |||
| Required for MYLIP-triggered down-regulation of LDLR. {ECO:0000269|PubMed:19520913} | 811..860 | 11/50 (22%) | |||
| NPXY motif. {ECO:0000269|PubMed:22509010} | 823..828 | 1/5 (20%) | |||
| yl | NP_996433.1 | LDLa | 90..124 | CDD:238060 | 16/48 (33%) |
| LDLa | 131..166 | CDD:238060 | 11/59 (19%) | ||
| LDLa | 184..216 | CDD:238060 | 17/32 (53%) | ||
| LDLa | 227..262 | CDD:238060 | 13/35 (37%) | ||
| LDLa | 271..302 | CDD:238060 | 15/31 (48%) | ||
| FXa_inhibition | 352..387 | CDD:291342 | 15/35 (43%) | ||
| Ldl_recept_b | 442..482 | CDD:278487 | 11/43 (26%) | ||
| LY | 466..508 | CDD:214531 | 13/42 (31%) | ||
| Ldl_recept_b | 529..569 | CDD:278487 | 18/40 (45%) | ||
| LY | 553..595 | CDD:214531 | 19/42 (45%) | ||
| LY | 596..637 | CDD:214531 | 14/43 (33%) | ||
| FXa_inhibition | 669..700 | CDD:291342 | 20/35 (57%) | ||
| LY | 774..815 | CDD:214531 | 5/41 (12%) | ||
| LDLa | 1032..1062 | CDD:238060 | |||
| LDLa | 1074..1109 | CDD:238060 | |||
| LDLa | 1118..1152 | CDD:238060 | |||
| LDLa | 1157..1189 | CDD:197566 | |||
| LDLa | 1198..1232 | CDD:238060 | |||
| LDLa | 1243..1279 | CDD:238060 | |||
| LDLa | 1283..1318 | CDD:238060 | |||
| LDLa | 1340..1371 | CDD:197566 | |||
| FXa_inhibition | 1388..1416 | CDD:291342 | |||
| EGF_CA | 1418..1452 | CDD:214542 | |||
| Blue background indicates that the domain is not in the aligned region. | |||||
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 0 | 0.000 | Not matched by this tool. | |||
| eggNOG | 1 | 0.900 | E1_KOG1215 | |||
| Hieranoid | 0 | 0.000 | Not matched by this tool. | |||
| Homologene | 0 | 0.000 | Not matched by this tool. | |||
| Inparanoid | 0 | 0.000 | Not matched by this tool. | |||
| Isobase | 0 | 0.000 | Not matched by this tool. | |||
| OMA | 0 | 0.000 | Not matched by this tool. | |||
| OrthoDB | 0 | 0.000 | Not matched by this tool. | |||
| OrthoFinder | 1 | 1.000 | FOG0000315 | |||
| OrthoInspector | 0 | 0.000 | Not matched by this tool. | |||
| orthoMCL | 0 | 0.000 | Not matched by this tool. | |||
| Panther | 0 | 0.000 | Not matched by this tool. | |||
| Phylome | 0 | 0.000 | Not matched by this tool. | |||
| RoundUp | 0 | 0.000 | Not matched by this tool. | |||
| TreeFam | 0 | 0.000 | Not matched by this tool. | |||
| User_Submission | 0 | 0.000 | Not matched by this tool. | |||
| 2 | 1.900 | |||||