DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment LDLR and LpR1

DIOPT Version :10

Sequence 1:NP_000518.1 Gene:LDLR / 3949 HGNCID:6547 Length:860 Species:Homo sapiens
Sequence 2:NP_001097934.2 Gene:LpR1 / 2768687 FlyBaseID:FBgn0066101 Length:1076 Species:Drosophila melanogaster


Alignment Length:847 Identity:331/847 - (39%)
Similarity:481/847 - (56%) Gaps:56/847 - (6%)


- Green bases have known domain annotations that are detailed below.


Human    27 CERNEFQCQD-GKCISYKWVCDGSAECQDGSDESQETCLSVTCKSGDFSCGGRVNRCIPQFWRCD 90
            |..|||:||. .:||...|:||||.:|:|.|||:.  |.:.||...:::|.....:|:|..|.||
  Fly   219 CPNNEFKCQTVDQCIPRSWLCDGSNDCRDKSDEAH--CRARTCSPDEYACKSGEGQCVPLAWMCD 281

Human    91 GQVDCDNGSDEQGCPPKTCSQDEFRCHDGKCISRQFVCDSDRDCLDGSDEASCPVLTC-GPASFQ 154
            ...||.:||||..| .:||..|||.|.:|:||.:::.||.|.||.|||||..|||:.| ..|...
  Fly   282 QSKDCSDGSDEHNC-NQTCRADEFTCGNGRCIQKRWKCDHDDDCGDGSDEKECPVVPCDSVAEHT 345

Human   155 CNSSTCIPQLWACDNDPDCEDGSDEWPQRCRGLYVFQGDSSPCSAFEFHCLSG-ECIHSSWRCDG 218
            |.:..||.:.|.||.||||.|||||  :.|..:   ...::||.:.|:.|... .|:|.||.|||
  Fly   346 CTNGACIAKRWVCDGDPDCSDGSDE--RSCANV---TKTTTPCLSHEYQCKDRITCLHHSWLCDG 405

Human   219 GPDCKDKSDEE--NCAVATCRPDEFQCSDGNCIHGSRQCDREYDCKDMSDEVGC-------VNVT 274
            ..||.|..||.  ||...|||.|:|||.|.:||.|...|:.:.||.|.|||..|       :|..
  Fly   406 DRDCPDGDDEHTANCKNVTCRADQFQCGDRSCIPGHLTCNGDKDCADGSDERDCGLSLSLGINQG 470

Human   275 LCEGPNKFKCHSGECITLDKVCNMARDCRDWSDEPIKECGTNECLDNNGGCSHVCNDLKIGYECL 339
            .|...::|.|..|:|:.|.|||:..:||.|..|||..:||.|||...||||.|.|.|||:|:.|.
  Fly   471 GCNATSEFDCGGGQCVPLSKVCDKRKDCPDGEDEPAGKCGINECASKNGGCMHQCIDLKVGHHCE 535

Human   340 CPDGFQLVAQRR-CEDIDECQDPDTCSQLCVNLEGGYKCQCEEGFQLDP--HTKACKAVGSIAYL 401
            |.:|::|...:| |:||:||:.|..|||:|||..||:||:||.|:..||  ||: |||....|.|
  Fly   536 CHEGYKLSPDKRNCQDINECEVPGKCSQICVNEIGGFKCECEAGYMRDPKNHTR-CKASEGHASL 599

Human   402 FFTNRHEVRKMTLDRSEYTSLIPNLRNVVALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYD 466
            ....||::||:.||..|.||::.:.:...|||....:..|:|||::.:.|....:|..   :...
  Fly   600 LLARRHDIRKIALDHMEMTSIVNSTKAATALDFVFRTGMIFWSDVTTQSIYKAPIDEG---NEKT 661

Human   467 TVISRDIQAPDGLAVDWIHSNIYWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFM 531
            .|:::.....||||||||::::|:||:...|:.:.:.:|...|.|.:::...||:|.:||:.|:|
  Fly   662 VVLTKSSVTSDGLAVDWIYNHVYFTDTHKCTIELTNFEGSMGKVLVKDSLDIPRSIALDPIEGWM 726

Human   532 YWTDWGTPAKIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNRK 596
            ||:|||...:|::.|::|....::::.:::|||||||||:..|:||||.||:.|||.:.:|..|.
  Fly   727 YWSDWGASPRIERAGMDGSHRTTIISYDVKWPNGITLDLVKKRIYWVDGKLNVISSANYDGSQRS 791

Human   597 TILEDEKRLAHPFSLAVFEDKVFWTDIINEAIFSANRLTGSDVN-LLAENLLS-PEDMVLFHNLT 659
            .:|...:.|.||||:..|||.|:|||...:|:|.||:.||.||. :.|.::|. |..:.::|...
  Fly   792 QVLYSGEYLRHPFSITTFEDNVYWTDWDKQAVFKANKFTGEDVEPVTAMHMLQHPMVVHVYHPYR 856

Human   660 QPRGVNWCERTTLSNGGCQYLCLPAPQINPHSPKFTCACPDGMLLARDMRSC---------LTEA 715
            ||.|||.|:..   ||.|.:||||||:||..||:.:||||.|:.|..|...|         :|..
  Fly   857 QPDGVNHCQSV---NGHCSHLCLPAPRINERSPRISCACPTGLKLMVDGLMCVEDPLYLPPVTRP 918

Human   716 EAAVATQETSTVRLKVSSTAVRTQHTTTR-PVPDTSRLPGATPGLTTVEIV----TMSHQALGDV 775
            ..|..|:.......:...|.|:..|...| .:.|..:|....|.|.|..:.    ..:|..: :.
  Fly   919 PRARKTKPRPKSPRRRLPTGVQVGHADIRIEINDDLQLSTRLPLLPTTFVADQRPVKNHTQI-EK 982

Human   776 AGRGNEKKPSSVRALSIV-----LPIVLLVFLCLGVFLLWKNWRLKNINSINFDNPVYQKTTEDE 835
            ....:|:..|...||.::     ..::|.|.|.:|    ::....:.|||:||:||:|:|||..|
  Fly   983 TTTPSEQPDSGFIALVVIASLSGFAVLLSVLLLIG----YRYCSKRRINSMNFENPIYRKTTTTE 1043

Human   836 VH 837
            .|
  Fly  1044 DH 1045

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LDLRNP_000518.1 Ldl_recept_a 25..58 CDD:395011 16/31 (52%)
Ldl_recept_a 66..104 CDD:395011 14/37 (38%)
Ldl_recept_a 107..143 CDD:395011 19/35 (54%)
Binding to Getah virus E1-E2 spike glycoproteins. /evidence=ECO:0000269|PubMed:38245515 146..233 36/90 (40%)
Ldl_recept_a 147..179 CDD:395011 15/32 (47%)
Ldl_recept_a 195..231 CDD:395011 16/38 (42%)
Ldl_recept_a 235..270 CDD:395011 18/34 (53%)
Ldl_recept_a 278..308 CDD:395011 11/29 (38%)
FXa_inhibition 318..>346 CDD:464251 14/27 (52%)
EGF_CA 354..388 CDD:214542 20/35 (57%)
LDL-receptor class B 1 397..438 14/40 (35%)
LY 419..457 CDD:214531 10/37 (27%)
LDL-receptor class B 2 439..485 14/45 (31%)
Ldl_recept_b 439..483 CDD:459654 12/43 (28%)
LDL-receptor class B 3 486..528 12/41 (29%)
Ldl_recept_b 487..526 CDD:459654 10/38 (26%)
LDL-receptor class B 4 529..572 19/42 (45%)
Ldl_recept_b 529..569 CDD:459654 16/39 (41%)
LY 553..595 CDD:214531 20/41 (49%)
LDL-receptor class B 5 573..615 18/41 (44%)
LDL-receptor class B 6 616..658 17/43 (40%)
Ldl_recept_b 616..656 CDD:459654 16/41 (39%)
FXa_inhibition 671..711 CDD:464251 20/39 (51%)
Clustered O-linked oligosaccharides 721..768 10/51 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 734..755 6/21 (29%)
Required for MYLIP-triggered down-regulation of LDLR. /evidence=ECO:0000269|PubMed:19520913 811..860 13/27 (48%)
NPXY motif. /evidence=ECO:0000269|PubMed:22509010 823..828 3/4 (75%)
LpR1NP_001097934.2 LDLa 135..167 CDD:197566
LDLa 178..210 CDD:197566
LDLa 219..254 CDD:238060 18/36 (50%)
LDLa 259..295 CDD:238060 13/35 (37%)
LDLa 343..373 CDD:238060 15/31 (48%)
LDLa 383..415 CDD:197566 13/31 (42%)
Ldl_recept_a 423..459 CDD:395011 18/35 (51%)
LDLa 476..504 CDD:197566 11/27 (41%)
FXa_inhibition 514..549 CDD:464251 16/34 (47%)
EGF_CA 551..581 CDD:214542 18/29 (62%)
LY 662..702 CDD:214531 14/39 (36%)
LY 704..747 CDD:214531 17/42 (40%)
LY 749..790 CDD:214531 20/40 (50%)
Ldl_recept_b 769..815 CDD:459654 22/45 (49%)
FXa_inhibition 864..905 CDD:464251 21/43 (49%)
Blue background indicates that the domain is not in the aligned region.

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