| Sequence 1: | NP_000518.1 | Gene: | LDLR | HGNCID: | 6547 | Length: | 860 | Species: | Homo sapiens |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_001097934.2 | Gene: | LpR1 | FlyBaseID: | FBgn0066101 | Length: | 1076 | Species: | Drosophila melanogaster |
| Alignment Length: | 847 | Identity: | 331/848 (39%) |
|---|---|---|---|
| Similarity: | 481/848 (57%) | Gaps: | 56/848 (7%) |
|
Human 27 CERNEFQCQD-GKCISYKWVCDGSAECQDGSDESQETCLSVTCKSGDFSCGGRVNRCIPQFWRCD 90
Human 91 GQVDCDNGSDEQGCPPKTCSQDEFRCHDGKCISRQFVCDSDRDCLDGSDEASCPVLTC-GPASFQ 154
Human 155 CNSSTCIPQLWACDNDPDCEDGSDEWPQRCRGLYVFQGDSSPCSAFEFHCLSG-ECIHSSWRCDG 218
Human 219 GPDCKDKSDEE--NCAVATCRPDEFQCSDGNCIHGSRQCDREYDCKDMSDEVGC-------VNVT 274
Human 275 LCEGPNKFKCHSGECITLDKVCNMARDCRDWSDEPIKECGTNECLDNNGGCSHVCNDLKIGYECL 339
Human 340 CPDGFQLVAQRR-CEDIDECQDPDTCSQLCVNLEGGYKCQCEEGFQLDP--HTKACKAVGSIAYL 401
Human 402 FFTNRHEVRKMTLDRSEYTSLIPNLRNVVALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYD 466
Human 467 TVISRDIQAPDGLAVDWIHSNIYWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFM 531
Human 532 YWTDWGTPAKIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNRK 596
Human 597 TILEDEKRLAHPFSLAVFEDKVFWTDIINEAIFSANRLTGSDVN-LLAENLLS-PEDMVLFHNLT 659
Human 660 QPRGVNWCERTTLSNGGCQYLCLPAPQINPHSPKFTCACPDGMLLARDMRSC---------LTEA 715
Human 716 EAAVATQETSTVRLKVSSTAVRTQHTTTR-PVPDTSRLPGATPGLTTVEIV----TMSHQALGDV 775
Human 776 AGRGNEKKPSSVRALSIV-----LPIVLLVFLCLGVFLLWKNWRLKNINSINFDNPVYQKTTEDE 835
Human 836 VH 837 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| LDLR | NP_000518.1 | Ldl_recept_a | 25..58 | CDD:278486 | 17/32 (53%) |
| Ldl_recept_a | 66..104 | CDD:278486 | 14/38 (37%) | ||
| Ldl_recept_a | 107..143 | CDD:278486 | 19/36 (53%) | ||
| Ldl_recept_a | 147..179 | CDD:278486 | 16/33 (48%) | ||
| Ldl_recept_a | 195..231 | CDD:278486 | 17/39 (44%) | ||
| Ldl_recept_a | 235..270 | CDD:278486 | 18/35 (51%) | ||
| LDLa | 278..308 | CDD:294076 | 12/30 (40%) | ||
| FXa_inhibition | 318..>346 | CDD:291342 | 14/28 (50%) | ||
| EGF_CA | 354..388 | CDD:214542 | 20/36 (56%) | ||
| LDL-receptor class B 1 | 397..438 | 14/41 (34%) | |||
| LY | 419..457 | CDD:214531 | 10/38 (26%) | ||
| LDL-receptor class B 2 | 439..485 | 15/46 (33%) | |||
| Ldl_recept_b | 439..482 | CDD:278487 | 12/43 (28%) | ||
| LDL-receptor class B 3 | 486..528 | 12/42 (29%) | |||
| Ldl_recept_b | 487..525 | CDD:278487 | 10/38 (26%) | ||
| LDL-receptor class B 4 | 529..572 | 19/43 (44%) | |||
| Ldl_recept_b | 529..569 | CDD:278487 | 17/40 (43%) | ||
| LY | 553..595 | CDD:214531 | 20/42 (48%) | ||
| LDL-receptor class B 5 | 573..615 | 19/42 (45%) | |||
| LDL-receptor class B 6 | 616..658 | 17/44 (39%) | |||
| Ldl_recept_b | 616..655 | CDD:278487 | 16/41 (39%) | ||
| FXa_inhibition | 671..711 | CDD:291342 | 20/40 (50%) | ||
| Clustered O-linked oligosaccharides | 721..768 | 10/52 (19%) | |||
| Required for MYLIP-triggered down-regulation of LDLR. {ECO:0000269|PubMed:19520913} | 811..860 | 13/28 (46%) | |||
| NPXY motif. {ECO:0000269|PubMed:22509010} | 823..828 | 3/5 (60%) | |||
| LpR1 | NP_001097934.2 | LDLa | 135..167 | CDD:197566 | |
| LDLa | 178..210 | CDD:197566 | |||
| LDLa | 219..254 | CDD:238060 | 18/37 (49%) | ||
| LDLa | 259..295 | CDD:238060 | 13/36 (36%) | ||
| LDLa | 343..373 | CDD:238060 | 15/32 (47%) | ||
| LDLa | 383..415 | CDD:197566 | 14/32 (44%) | ||
| Ldl_recept_a | 423..459 | CDD:278486 | 18/36 (50%) | ||
| LDLa | 476..504 | CDD:197566 | 12/28 (43%) | ||
| FXa_inhibition | 514..549 | CDD:291342 | 16/35 (46%) | ||
| EGF_CA | 551..581 | CDD:214542 | 18/30 (60%) | ||
| LY | 662..702 | CDD:214531 | 14/40 (35%) | ||
| LY | 704..747 | CDD:214531 | 17/43 (40%) | ||
| LY | 749..790 | CDD:214531 | 20/41 (49%) | ||
| FXa_inhibition | 864..905 | CDD:291342 | 21/44 (48%) | ||
| Blue background indicates that the domain is not in the aligned region. | |||||
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 0 | 0.000 | Not matched by this tool. | |||
| eggNOG | 0 | 0.000 | Not matched by this tool. | |||
| Hieranoid | 1 | 1.000 | ||||
| Homologene | 0 | 0.000 | Not matched by this tool. | |||
| Inparanoid | 1 | 1.050 | 713 | 1.000 | Inparanoid score | I631 |
| Isobase | 0 | 0.000 | Not matched by this tool. | |||
| OMA | 1 | 1.010 | ||||
| OrthoDB | 1 | 1.010 | D179614at33208 | |||
| OrthoFinder | 1 | 1.000 | FOG0000315 | |||
| OrthoInspector | 1 | 1.000 | T130091 | |||
| orthoMCL | 0 | 0.000 | Not matched by this tool. | |||
| Panther | 1 | 1.100 | O | PTHR24270 | ||
| Phylome | 1 | 0.910 | 0.857 | Consistency score | ||
| RoundUp | 1 | 1.030 | avgDist | Average_Evolutionary_Distance | R7933 | |
| TreeFam | 0 | 0.000 | Not matched by this tool. | |||
| User_Submission | 0 | 0.000 | Not matched by this tool. | |||
| 9 | 9.110 | |||||