Protein Alignment Srrm1 and SRRM1

DIOPT Version :10

• Sequence 1: NP_648627.1
• Gene: Srrm1 / 39483
• FlyBaseID: FBgn0036340
• Length: 954
• Species: Drosophila melanogaster
• Sequence 2: NP_001353524.1
• Gene: SRRM1 / 10250
• HGNCID: 16638
• Length: 918
• Species: Homo sapiens
• Alignment Length: 1056
• Identity: 327/1056 - (30%)
• Similarity: 467/1056 - (44%)
• Gaps: 256/1056 - (24%)

  Fly     3 FTGTNQQQDTRFSDKEKKLMKQMKFGDCLNKRVDMSKVKLDVLRPWISKKITDILHIEDDVVVEF 67
            |.||:.:||.|||:|:|||:||:||.:||.|:||||||.|:|::|||:|::|:||..|||||:||
Human     6 FRGTSAEQDNRFSNKQKKLLKQLKFAECLEKKVDMSKVNLEVIKPWITKRVTEILGFEDDVVIEF 70

  Fly    68 VYNQLEEEKYPCPKKMQINMTGFLNGRNARQFMGELWALLLSAQESDSGIPAEFIQQKKDEILKR 132
            ::||| |.|.|..|.||||:||||||:|||:||||||.|||||||:.:|||:.|::.||:||.:|
Human    71 IFNQL-EVKNPDSKMMQINLTGFLNGKNAREFMGELWPLLLSAQENIAGIPSAFLELKKEEIKQR 134

  Fly   133 EEEQ------RQRDRSRSRSRSRSQRDSSRRDRQRDRSKSKSRSRSRSMKPANNNGSVPSAAREA 191
            :.||      :::|..:.: |.:.:::|||  .:|:||:|..|.:|||..|
Human   135 QIEQEKLASMKKQDEDKDK-RDKEEKESSR--EKRERSRSPRRRKSRSPSP-------------- 182

  Fly   192 AANAAAKIRKRGSSSAARPGSRERRSSRRPRSRSRSRSRTAG--KKTGSVE-PAPA-----KTVN 248
                     :|.||...|  .|:|..||.||.|::|||.:..  ||..:.| |.|:     .:|.
Human   183 ---------RRRSSPVRR--ERKRSHSRSPRHRTKSRSPSPAPEKKEKTPELPEPSVKVKEPSVQ 236

  Fly   249 GRHSTD------KSSPVP----PASKNKSRSRSHSRSRSPRSRSRSPSAKRSRSRSSSR-RSRRR 302
            ...||.      |..|:|    |:.:..|:.........|||||||.|..|:||||.|. |.|||
Human   237 EATSTSDILKVPKPEPIPEPKEPSPEKNSKKEKEKEKTRPRSRSRSKSRSRTRSRSPSHTRPRRR 301

  Fly   303 GRSSSISLSPERNQDQF------------------EHRRNKNSVQNKRQYRNNRGDSASSMERGN 349
            .||.|.|.||.|.....                  .|||:::.|:.:|  |::...|.||....:
Human   302 HRSRSRSYSPRRRPSPRRRPSPRRRTPPRRMPPPPRHRRSRSPVRRRR--RSSASLSGSSSSSSS 364

  Fly   350 DRGRQFGGGGGGR-----RGGRRFSPRGRSPMRQDNGGGNGGNRFQRSNSRRRSRSRRLSRSP-- 407
            .|.|........|     |..||.||....|                   |||.|....:..|
Human   365 SRSRSPPKKPPKRTSSPPRKTRRLSPSASPP-------------------RRRHRPSPPATPPPK 410

  Fly   408 MRYSRSPRRFNNRRRSPMMNFRGGGRGGGRGGGHRQMWQHRGGSPNFRGGGRIHWQARHSPGGGG 472
            .|:|.:|::.|..|:|.:      ....||..|  ::.:|:|            .:.|.||....
Human   411 TRHSPTPQQSNRTRKSRV------SVSPGRTSG--KVTKHKG------------TEKRESPSPAP 455

  Fly   473 R-----------GGGGGMGRFDRRQSPQQNRYNRDHRQ--------SPMQQNQPFRKQFSPHQ-G 517
            :           ..||.|...|..|  |:.:|.|.::|        |..:..:|.|......: |
Human   456 KPRKVELSESEEDKGGKMAAADSVQ--QRRQYRRQNQQSSSDSGSSSSSEDERPKRSHVKNGEVG 518

  Fly   518 PGRRFS-----SPQQRRNSRDRRPNSR--ERRSSPGGGGGHMNRWDNPPPARNRRSSSGSSAGGR 575
            ..||.|     ||..|:..::..|..:  :|..||....|...|..:|||.|.|||.|.:....|
Human   519 RRRRHSPSRSASPSPRKRQKETSPRMQMGKRWQSPVTKSGRRRRSPSPPPTRRRRSPSPAPPPRR 583

  Fly   576 QQ------RQRSASPPEKRRSSHSR--SRSLSRNRSRS-----RSSS----QHSRKRESPIGRSS 623
            ::      |:|:.|||.:|||...|  |..:.|..|.|     |::|    ...|...||..:..
Human   584 RRTPTPPPRRRTPSPPPRRRSPSPRRYSPPIQRRYSPSPPPKRRTASPPPPPKRRASPSPPPKRR 648

  Fly   624 VEYAGPAVNTIDLCREEQQRKNKPETIIVLDEGPAVRSSYASLSRTPSPFLKPHERLAAAKAAAA 688
            |.::.|                           |..|||..:..|:||
Human   649 VSHSPP---------------------------PKQRSSPVTKRRSPS----------------- 669

  Fly   689 ASAAVPKKSRDQSQSSSSDSSAESDDSEEQPRRKKQPTNMETSKGKKEKVRRSSESSTSSEQSDD 753
                :..|.|..|..|.|...|.|....::.....:|...:|| .....|||.:.||....|| .
Human   670 ----LSSKHRKGSSPSRSTREARSPQPNKRHSPSPRPRAPQTS-SSPPPVRRGASSSPQRRQS-P 728

  Fly   754 EDNSSGDERLKKKLQQRKSKEAAALKGKEKEHEKEKDKRRSDKKSKRGAISSGDEESTSSRKRGH 818
            ..::....|:.:..:.:|.|:||:       ...:..:|.|..:|     .||..|..:
Human   729 SPSTRPIRRVSRTPEPKKIKKAAS-------PSPQSVRRVSSSRS-----VSGSPEPAA------ 775

  Fly   819 KKTRRDEAGDNSDSEDEH----VPKKKRKK-AKKPADSSDSDSEASSKRKKHKKHKKH--SKKSK 876
            ||.....:...|.|...:    ||.||.|. ...|:...:||.|...|:||.||.|||  .||.|
Human   776 KKPPAPPSPVQSQSPSTNWSPAVPVKKAKSPTPSPSPPRNSDQEGGGKKKKKKKDKKHKKDKKHK 840

  Fly   877 KHKKHKRKCSAGKSRADSSSQGSSDEDEQLPHSVAAKRNGNAGKLALLLP-----GASGAGVINE 936
            ||||||::.:...:.|.:.:          |.::||.....|.:..:..|     ..|.|....:
Human   841 KHKKHKKEKAVAAAAAAAVT----------PAAIAAATTTLAQEEPVAAPEPKKETESEAEDNLD 895

  Fly   937 DLEKQLRERALKSMKK 952
            ||||.|||:||:||:|
Human   896 DLEKHLREKALRSMRK 911

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Srrm1	NP_648627.1	PWI	43..115	CDD:460224	48/71 (68%)
SRRM1	NP_001353524.1	Necessary for mRNA 3'-end cleavage and cytoplasmic accumulation	1..156		87/151 (58%)
		Necessary for DNA and RNA-binding	1..151		86/145 (59%)
		PWI	46..115	CDD:460224	47/69 (68%)
		PHA03307	<620..>754	CDD:223039	37/190 (19%)