Protein Alignment Cul6 and RTT101

DIOPT Version :10

• Sequence 1: NP_648620.1
• Gene: Cul6 / 39474
• FlyBaseID: FBgn0036332
• Length: 670
• Species: Drosophila melanogaster
• Sequence 2: NP_012488.3
• Gene: RTT101 / 853400
• SGDID: S000003583
• Length: 842
• Species: Saccharomyces cerevisiae
• Alignment Length: 893
• Identity: 163/893 - (18%)
• Similarity: 289/893 - (32%)
• Gaps: 317/893 - (35%)

  Fly    20 NILQVVNQIFDD----YTSFDGQKLMHLYHLIYKQCAAERNW------NNPAQKNGRSLYIVLSD 74
            |.|.:.|:..|:    |.:...: |...:||...:...|.:.      ...|.|..:.:..:|::
Yeast    24 NALGLYNKFNDERNPRYRTMIAE-LHEFFHLTLAETITETDVKELECNKEKAAKFRKLMPKMLNN 87

  Fly    75 C--LMKRLKNIAWVMENQLDDNKPIRLIAKYLEHWV--PYQRSCEKLN------------LAC-Y 122
            |  |.:|...|.:..|...:|.|..:....: :|.:  .:|..|::|.            ..| |
Yeast    88 CRELTQRKSYIPYNSEFNGNDEKQKKFQLLH-QHQIVLSFQEFCDELAKLIIDAHVLSFLTRCDY 151

  Fly   123 HFN---RNWVERERLKGDKETYPIYRLAMISWKELVFEPSVTILAAIRLILSQMPREY---NKSL 181
            .:.   :||..            .|:|...            ::.|:..|:|.:|..|   .|.|
Yeast   152 SYEIIPKNWTS------------FYKLFQY------------VMGAVGPIISYVPVNYPMIRKEL 192

  Fly   182 EYQVYQVLQSIVELYANDKYQDVSLPSRIDKIFTEKVMDFYKSTTLHEFQKI------------- 233
            .::...:.|     |.:.|..: .:.|...:.|:..|     |.|:|.:..:
Yeast   193 GFETLTIFQ-----YYDSKLFE-CMKSHFGREFSTLV-----SATIHHYIHMFPITNTMLEKEVP 246

  Fly   234 ---VVSN--------DYKDF--KHFLRYAC---LAMPEIENGTQFKAILKR-------------- 268
               ::||        ..|||  |...:|.|   ...|.:|....||.:|.|
Yeast   247 MLRIMSNCNFSIEGLSPKDFYMKTLRQYYCEESNLRPRLETFKNFKVLLTRNALLASLFSPEWVS 311

  Fly   269 ----YLAARLQETRLSGKDYIQAFLGLCRGPLQRALRDHTKLAEVV--------------DAVCK 315
                ...:.|...:.|..:||:..........:|..:..|..:.::              ...|.
Yeast   312 DANDLFISHLLLNKKSISEYIEIGKDTYDEEKERYFKTETHFSLLMFRNAFEAKNMLSKFKEFCD 376

  Fly   316 EEINRKGQIIDPTRLLVTYANELMTKRQESEE---AIIDELKRIVKCVEF-----LSDEYKFIDM 372
            :.::.|        |...|.:...|:|...|.   |.:|.||.....:|:     |....|.|:.
Yeast   377 DAVSEK--------LKAAYGSNHDTERLFDEVVQLANVDHLKIYSDSIEYHLCNLLGSTSKAIEQ 433

  Fly   373 YLKALR------IRQINETSTSDGVESIMYSLLNKKM-------------ANFVTRCIYVQ---- 414
            |:|...      :|:| :|:..|....:....||:.:             .||..|.|:.:
Yeast   434 YVKYFESHLFIIVRKI-KTTKKDLPRDMKIKYLNENLPILRLKFVNLPTFPNFFERSIFRKTILQ 497

  Fly   415 -------LRDV-----DKLRTLKK-----------------EFQDHL------------------ 432
                   ::|:     |.|..|.|                 ::|.:|
Yeast   498 SDQNSSFIKDILPVYKDSLMELFKQRIITNVSQEDEMRYRDQYQPYLSQFFQPVEVMADLRIKYA 562

  Fly   433 ----------------------NSKG-IKLGFDFR--PKCFKNDGSFENFNLTLPDELQQAWKEF 472
                                  |||. ..|.||..  ||.|:.....:. |..||.|:...|.:|
Yeast   563 SFLSFYENIEAAVKFGKTYNENNSKSFFPLIFDRERIPKVFQQSNEVKK-NFVLPQEMDDTWNQF 626

  Fly   473 -RIFYEARKLQSKAIIQLNNELSSGEI-------TCHLNQSVYIL--------EVSTLQMAVLML 521
             |.::|..|::       :::.|..|:       .|.: :|.||:        |::..|..||.|
Yeast   627 LRNYHEQNKVE-------DSDASKKELYPMWNLHHCEV-ESPYIIQDGTNLIFELTLFQTCVLTL 683

  Fly   522 FNRHERFTEQELVTALGVELETLQEALK-QIKFLVYIEVNKVNYIEINMDFTNRKRRLFCNEPLP 585
            ||..:..|           |:.:.|..| ..|.|..:..:..||..:..|..|   ....||...
Yeast   684 FNESDHLT-----------LQVISEQTKLAYKDLALVLKSFCNYKILTRDIDN---TYSINESFK 734

  Fly   586 RKMRKIEEKSEIELKIRR---------------------------DKQVDAAIVRIMKGQKQ-LE 622
            ..|:|: :..::.:.:.|                           .:.:.|.|.|.:|.::. |:
Yeast   735 PDMKKV-KNGKLRVVLPRTASLQSSNTGGERTSSAHHEGSNSQWTQELLKACITRSVKSERNGLD 798

  Fly   623 YSELISLVYEELKDRVKP-QVSFIKKRLDYLVEREYLERDNYYNIYRY 669
            |..|    :|.:|.::|. .|...|..|..|:..:::.||.....|:|
Yeast   799 YDHL----FETVKQQIKGFSVGEFKDALAKLLRDKFITRDESTATYKY 842

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cul6	NP_648620.1	COG5647	25..670	CDD:227934	161/888 (18%)
RTT101	NP_012488.3	COG5647	<519..842	CDD:227934	67/350 (19%)