Protein Alignment Cul6 and CUL3

DIOPT Version :10

• Sequence 1: NP_648620.1
• Gene: Cul6 / 39474
• FlyBaseID: FBgn0036332
• Length: 670
• Species: Drosophila melanogaster
• Sequence 2: NP_011517.1
• Gene: CUL3 / 852886
• SGDID: S000003235
• Length: 744
• Species: Saccharomyces cerevisiae
• Alignment Length: 775
• Identity: 152/775 - (19%)
• Similarity: 297/775 - (38%)
• Gaps: 188/775 - (24%)

  Fly    19 DNILQVVNQIFDD---YTSFDGQKLMHLYHLIYKQCAAERNWNNPAQKNGRSLYIVLSDCLMKRL 80
            :.:...::.|:.|   ..||:     .:|..||         .....|.|..||..|.|.|:::|
Yeast    27 ETVKYAIDHIYSDDMADLSFE-----QVYKTIY---------TIVLNKKGPILYNRLKDYLIQKL 77

  Fly    81 KNIAWVMENQLDDN-KPIRLIAKYLEHWVPYQRSCEKL--NLACYHFNRNWVERERLKGDK--ET 140
               |.:.|..:.|| .....:......| ..|..|.|:  :|..|      :::...|.::  |.
Yeast    78 ---ALLRETIVKDNTHDYEFLGTMARLW-EVQCHCFKITGDLMMY------MDKVYCKPNRCMEV 132

  Fly   141 Y----PIYRL------------AMIS------------------WKELV---------------- 155
            |    .::|:            |:||                  ||.|:
Yeast   133 YDMCLDLFRIEILQKCSSSLISALISDIERIRNLGSVDSEHTSLWKVLIGMMETLHDNRDSFFLT 197

  Fly   156 -FEPSVTILAAIRLILSQMPREYNKSLEYQVYQVLQSI--------VELYANDKYQDVSLPSRID 211
             |||         :::|.....|||:::.::...::|:        .|...:..:.:|...:::.
Yeast   198 DFEP---------VLISATEEYYNKAIDIELLTPIESLEKIRKLRQFESMLDSSFLNVDSHNKLK 253

  Fly   212 KIFTE-----KVMDFYKSTTLHEFQKIVVSND-------------------YKDFKHFLRYACLA 252
            .:...     |:.|..:..| ||  .:|:||.                   .:..|.::....:.
Yeast   254 TVLENVLIWGKLSDIIEDLT-HE--AMVISNGKLLQEIYDLSSEEKYRVTVIESIKSYINKNAIN 315

  Fly   253 MPEIENG--------TQFKAILKRYLAARLQETRLSGKDYIQAFLGLCRGPLQRALRDHTKLAEV 309
            :|..|..        |....|::.|   |.|.:.|...|:....|....|.:..|:     |.:|
Yeast   316 IPFNEGNRKKGQNAITWSSEIVELY---RSQHSFLESIDFGSVRLNNLTGDVSNAI-----LGDV 372

  Fly   310 VDAVCKEEINRKGQIIDPTRLLVTYANELMTKRQESEEAII---DELKRIVKCVEFLSDEYKFID 371
            ....    .:::|.:  |:..|.||.:..|.:.:|.:..|:   .:|....|.:..|:::..|..
Yeast   373 FSMY----FSKEGAL--PSEYLSTYVDHCMKRTKEKDAEIVKIKQDLLDSTKLIGLLTEKDIFEK 431

  Fly   372 MYLKALRIRQINETSTSDGVESIMYSLLNKKMANFVTRCIYVQLRDVDKLRTLKKEFQDHLNSKG 436
            :|.|.|..|.:.:.|..: :|..|..::.|.:..|.|..:.:.|||:.....:.:.|| |.....
Yeast   432 IYKKQLSRRLLQQRSLVE-IEKWMVQMIKKVLGTFFTSKLEIMLRDISLSSEMYQAFQ-HSTINS 494

  Fly   437 IKLGFDFRPKCF-KNDGSFENFN-----LTLPDELQQAWKEFRIFYEARKLQSKAIIQLNNELSS 495
            |:. ..|.|:.. :....|::.|     ::||..:.|....|..:|..:  ..:.:::..:.||.
Yeast   495 IEY-LSFAPQVLTRTSWPFQSTNPIDEGISLPPRMSQILAGFEGYYSLK--YKERVLKWAHHLSV 556

  Fly   496 GEITCHLNQSVYILEVSTLQMAVLMLFNRHERFTEQELVTALGVELETLQEALKQIKFLVYIEVN 560
            .||.|..|...|.:..|.....:.:||..:|..|..|:.....:.::.::..:..:..:...::.
Yeast   557 IEIGCQFNSGYYEISFSVYAGVIFLLFEDYEELTLGEIYELTHIPIDDVKSLVMSMSTIPRCKIL 621

  Fly   561 KVNYIEINMDFT--------NRKRR---LFCNEPLP-RKMRKIEEKSEIELKIRRDKQV----DA 609
            |.:....||.|:        |||.:   :.|  ||| :|...:...|.::   ..|.::    .|
Yeast   622 KKSSSSGNMKFSVNYFFSSPNRKVKVPVIAC--PLPSQKSDNLATASSVD---TYDNEIVMELSA 681

  Fly   610 AIVRIMKGQKQLEYSELISLVYEELKDRVKPQVSFIKKRLDYLVEREYLERD----NYYN 665
            .||||||.:.:|.:.:|:....:..:.|:....|.:|:.:..|:|:||::|:    :||:
Yeast   682 IIVRIMKTEGKLSHQQLLERTTKRTQSRLSLTPSILKRSIQLLIEKEYIQRNADDPSYYH 741

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cul6	NP_648620.1	COG5647	25..670	CDD:227934	152/769 (20%)
CUL3	NP_011517.1	COG5647	1..744	CDD:227934	152/775 (20%)