DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cul6 and CUL3

DIOPT Version :9

Sequence 1:	NP_648620.1	Gene:	Cul6 / 39474	FlyBaseID:	FBgn0036332	Length:	670	Species:	Drosophila melanogaster
Sequence 2:	NP_011517.1	Gene:	CUL3 / 852886	SGDID:	S000003235	Length:	744	Species:	Saccharomyces cerevisiae

Alignment Length:	775	Identity:	152/775 - (19%)
Similarity:	297/775 - (38%)	Gaps:	188/775 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 DNILQVVNQIFDD---YTSFDGQKLMHLYHLIYKQCAAERNWNNPAQKNGRSLYIVLSDCLMKRL 80
            :.:...::.|:.|   ..||:     .:|..||         .....|.|..||..|.|.|:::|
Yeast    27 ETVKYAIDHIYSDDMADLSFE-----QVYKTIY---------TIVLNKKGPILYNRLKDYLIQKL 77

  Fly    81 KNIAWVMENQLDDN-KPIRLIAKYLEHWVPYQRSCEKL--NLACYHFNRNWVERERLKGDK--ET 140
               |.:.|..:.|| .....:......| ..|..|.|:  :|..|      :::...|.::  |.
Yeast    78 ---ALLRETIVKDNTHDYEFLGTMARLW-EVQCHCFKITGDLMMY------MDKVYCKPNRCMEV 132

  Fly   141 Y----PIYRL------------AMIS------------------WKELV---------------- 155
            |    .::|:            |:||                  ||.|:
Yeast   133 YDMCLDLFRIEILQKCSSSLISALISDIERIRNLGSVDSEHTSLWKVLIGMMETLHDNRDSFFLT 197

  Fly   156 -FEPSVTILAAIRLILSQMPREYNKSLEYQVYQVLQSI--------VELYANDKYQDVSLPSRID 211
             |||         :::|.....|||:::.::...::|:        .|...:..:.:|...:::.
Yeast   198 DFEP---------VLISATEEYYNKAIDIELLTPIESLEKIRKLRQFESMLDSSFLNVDSHNKLK 253

  Fly   212 KIFTE-----KVMDFYKSTTLHEFQKIVVSND-------------------YKDFKHFLRYACLA 252
            .:...     |:.|..:..| ||  .:|:||.                   .:..|.::....:.
Yeast   254 TVLENVLIWGKLSDIIEDLT-HE--AMVISNGKLLQEIYDLSSEEKYRVTVIESIKSYINKNAIN 315

  Fly   253 MPEIENG--------TQFKAILKRYLAARLQETRLSGKDYIQAFLGLCRGPLQRALRDHTKLAEV 309
            :|..|..        |....|::.|   |.|.:.|...|:....|....|.:..|:     |.:|
Yeast   316 IPFNEGNRKKGQNAITWSSEIVELY---RSQHSFLESIDFGSVRLNNLTGDVSNAI-----LGDV 372

  Fly   310 VDAVCKEEINRKGQIIDPTRLLVTYANELMTKRQESEEAII---DELKRIVKCVEFLSDEYKFID 371
            ....    .:::|.:  |:..|.||.:..|.:.:|.:..|:   .:|....|.:..|:::..|..
Yeast   373 FSMY----FSKEGAL--PSEYLSTYVDHCMKRTKEKDAEIVKIKQDLLDSTKLIGLLTEKDIFEK 431

  Fly   372 MYLKALRIRQINETSTSDGVESIMYSLLNKKMANFVTRCIYVQLRDVDKLRTLKKEFQDHLNSKG 436
            :|.|.|..|.:.:.|..: :|..|..::.|.:..|.|..:.:.|||:.....:.:.|| |.....
Yeast   432 IYKKQLSRRLLQQRSLVE-IEKWMVQMIKKVLGTFFTSKLEIMLRDISLSSEMYQAFQ-HSTINS 494

  Fly   437 IKLGFDFRPKCF-KNDGSFENFN-----LTLPDELQQAWKEFRIFYEARKLQSKAIIQLNNELSS 495
            |:. ..|.|:.. :....|::.|     ::||..:.|....|..:|..:  ..:.:::..:.||.
Yeast   495 IEY-LSFAPQVLTRTSWPFQSTNPIDEGISLPPRMSQILAGFEGYYSLK--YKERVLKWAHHLSV 556

  Fly   496 GEITCHLNQSVYILEVSTLQMAVLMLFNRHERFTEQELVTALGVELETLQEALKQIKFLVYIEVN 560
            .||.|..|...|.:..|.....:.:||..:|..|..|:.....:.::.::..:..:..:...::.
Yeast   557 IEIGCQFNSGYYEISFSVYAGVIFLLFEDYEELTLGEIYELTHIPIDDVKSLVMSMSTIPRCKIL 621

  Fly   561 KVNYIEINMDFT--------NRKRR---LFCNEPLP-RKMRKIEEKSEIELKIRRDKQV----DA 609
            |.:....||.|:        |||.:   :.|  ||| :|...:...|.::   ..|.::    .|
Yeast   622 KKSSSSGNMKFSVNYFFSSPNRKVKVPVIAC--PLPSQKSDNLATASSVD---TYDNEIVMELSA 681

  Fly   610 AIVRIMKGQKQLEYSELISLVYEELKDRVKPQVSFIKKRLDYLVEREYLERD----NYYN 665
            .||||||.:.:|.:.:|:....:..:.|:....|.:|:.:..|:|:||::|:    :||:
Yeast   682 IIVRIMKTEGKLSHQQLLERTTKRTQSRLSLTPSILKRSIQLLIEKEYIQRNADDPSYYH 741

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cul6	NP_648620.1	COG5647	25..670	CDD:227934	152/769 (20%)
		CULLIN	362..500	CDD:214545	32/143 (22%)
		Cullin_Nedd8	606..661	CDD:287520	16/58 (28%)
CUL3	NP_011517.1	COG5647	1..744	CDD:227934	152/775 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	52	1.000	Domainoid score	I2831
eggNOG	1	0.900	-	-		E1_COG5647
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810