Protein Alignment Cul6 and CUL2

DIOPT Version :10

• Sequence 1: NP_648620.1
• Gene: Cul6 / 39474
• FlyBaseID: FBgn0036332
• Length: 670
• Species: Drosophila melanogaster
• Sequence 2: XP_011518045.1
• Gene: CUL2 / 8453
• HGNCID: 2552
• Length: 808
• Species: Homo sapiens
• Alignment Length: 793
• Identity: 159/793 - (20%)
• Similarity: 307/793 - (38%)
• Gaps: 182/793 - (22%)

  Fly     1 MNRVKRISNYFDSMLPLIDNILQVV----------NQIFDDYTSFDGQKLMHLYHLIYKQCAAER 55
            |:...|:.::.::...|:..|..||          |..|.|               ||..|.|
Human    64 MSLKPRVVDFDETWNKLLTTIKAVVMLEYVERATWNDRFSD---------------IYALCVA-- 111

  Fly    56 NWNNPAQKNGRSLYIVLSDCLMKRLKNI-AWVMENQLDDNKPIRLIAKYLEHWVPYQRSCEKLNL 119
             :..|.   |..||......|...:::: ..|:|::      .:::..|..:|..|.:..:.::.
Human   112 -YPEPL---GERLYTETKIFLENHVRHLHKRVLESE------EQVLVMYHRYWEEYSKGADYMDC 166

  Fly   120 ACYHFNRNWVERERLKGDKETY------------PIYRLAMISWKELVFEPSVTILAAIRLILSQ 172
            ...:.|..::::.:|......|            .|..||:..|::|:.||...||  ||::|.:
Human   167 LYRYLNTQFIKKNKLTEADLQYGYGGVDMNEPLMEIGELALDMWRKLMVEPLQAIL--IRMLLRE 229

  Fly   173 MP-----------------------REYNKSLEYQVYQVLQSIVELYANDKY--QDVS--LPSRI 210
            :.                       .:|.|....:.||.:.....|....:|  |:.|  |....
Human   230 IKNDRGGEDPNQKVIHGVINSFVHVEQYKKKFPLKFYQEIFESPFLTETGEYYKQEASNLLQESN 294

  Fly   211 DKIFTEKVMDFYK---------------STTLHEFQKIVVSNDYKDFKHFLRYAC--LAMPEIEN 258
            ...:.|||:...|               :..:||.|:.:|:    |...||...|  :...|.:|
Human   295 CSQYMEKVLGRLKDEEIRCRKYLHPSSYTKVIHECQQRMVA----DHLQFLHAECHNIIRQEKKN 355

  Fly   259 GTQFKAILKRYLAARL----QE-------------TRLSGKDYIQAFLGLCRGPLQRALRDHTKL 306
            ......:|.|.::..|    ||             :.|:.::....|       ::..|..|.|.
Human   356 DMANMYVLLRAVSTGLPHMIQELQNHIHDEGLRATSNLTQENMPTLF-------VESVLEVHGKF 413

  Fly   307 AEVVDAVCKEE--------------INRK--GQIIDPTRLLVTYANELMTKRQE--SEEAIIDEL 353
            .::::.|...:              :|.:  ..:.....||..|.:.|:.|..:  :|..:.|.|
Human   414 VQLINTVLNGDQHFMSALDKALTSVVNYREPKSVCKAPELLAKYCDNLLKKSAKGMTENEVEDRL 478

  Fly   354 KRIVKCVEFLSDEYKFIDMYLKALRIRQINETSTSDGVESIMYSLLNKKMANFVTRCIYVQLRDV 418
            ...:...:::.|:..|...|.:.|..|.|:..|.|...|..|.:.|.:......|..::....|:
Human   479 TSFITVFKYIDDKDVFQKFYARMLAKRLIHGLSMSMDSEEAMINKLKQACGYEFTSKLHRMYTDM 543

  Fly   419 DKLRTLKKEFQDHLNSKG--IKLGFDFR---------PKCFKNDGSFENFNLTLPDELQQAWKEF 472
            .....|..:|.:.:.::.  |.||..|:         |.......:|     .:|.||:::.:.|
Human   544 SVSADLNNKFNNFIKNQDTVIDLGISFQIYVLQAGAWPLTQAPSSTF-----AIPQELEKSVQMF 603

  Fly   473 RIFYEARKLQSKAIIQLNNELSSGEITCHLNQSVYILEVSTLQMAVLMLFNRHERFTEQELVTAL 537
            .:|| ::....:.:..| :.|.:||:..:.....|:..|:|.|||||:.||..|..:.:||..:.
Human   604 ELFY-SQHFSGRKLTWL-HYLCTGEVKMNYLGKPYVAMVTTYQMAVLLAFNNSETVSYKELQDST 666

  Fly   538 GVELETLQEALKQIKFLVYIEVNKVNY------------IEINMDFTNRKRRLFCNEPLPRKMRK 590
            .:..:.|.:.:|.:     ::|..:|:            ..:||:|::::.:......:.:...:
Human   667 QMNEKELTKTIKSL-----LDVKMINHDSEKEDIDAESSFSLNMNFSSKRTKFKITTSMQKDTPQ 726

  Fly   591 IEEKSEIELKIRRDKQVDAAIVRIMKGQKQLEYSELISLVYEELKDRVKPQVSFIKKRLDYLVER 655
            ..|::...:...|...:.||||||||.:|.|.::.||..|..:.:.|..|.:|.|||.::.|:::
Human   727 EMEQTRSAVDEDRKMYLQAAIVRIMKARKVLRHNALIQEVISQSRARFNPSISMIKKCIEVLIDK 791

  Fly   656 EYLER-----DNY 663
            :|:||     |.|
Human   792 QYIERSQASADEY 804

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cul6	NP_648620.1	COG5647	25..670	CDD:227934	154/769 (20%)
CUL2	XP_011518045.1	Cullin	77..707	CDD:459983	129/681 (19%)
		Cullin_Nedd8	738..798	CDD:463146	24/59 (41%)