Protein Alignment Cul6 and CUL4B

DIOPT Version :10

• Sequence 1: NP_648620.1
• Gene: Cul6 / 39474
• FlyBaseID: FBgn0036332
• Length: 670
• Species: Drosophila melanogaster
• Sequence 2: NP_003579.3
• Gene: CUL4B / 8450
• HGNCID: 2555
• Length: 913
• Species: Homo sapiens
• Alignment Length: 755
• Identity: 169/755 - (22%)
• Similarity: 307/755 - (40%)
• Gaps: 173/755 - (22%)

  Fly    30 DDYTSFDGQKLMHLYHLIYKQCAAERNWNNPAQKNGRSLYIVLSDCLMKRLKNI------AWVME 88
            ::||....|||......|....:.:.|.....|.........:|..|.|:|:.|      |.:.:
Human   210 ENYTDETWQKLKEAVEAIQNSTSIKYNLEELYQAVENLCSYKISANLYKQLRQICEDHIKAQIHQ 274

  Fly    89 NQLDDNKPIRLIAKYLEHWVPYQRSCEKLNLACYHFNRNWVERERLKGDKETYP--------IYR 145
            .:.|....:..:.|....|..:.|....:.......:|.:|.:..:      .|        ::|
Human   275 FREDSLDSVLFLKKIDRCWQNHCRQMIMIRSIFLFLDRTYVLQNSM------LPSIWDMGLELFR 333

  Fly   146 LAMISWKELVFEPSVTILAAIRLILSQMPREYN-----KSLEYQVYQVLQSIVELYAN-DKYQDV 204
            ..:||.:::   .:.||...:.||    .||.|     :||       |:|::.:.:: ..|||
Human   334 AHIISDQKV---QNKTIDGILLLI----ERERNGEAIDRSL-------LRSLLSMLSDLQIYQD- 383

  Fly   205 SLPSRIDKIFTEKVMDFYKSTTLHEFQKIVVSNDYKDFKHFL-------------------RYAC 250
                ..::.|.|:....|.:    |.||::...:..::.|.:                   :.:.
Human   384 ----SFEQRFLEETNRLYAA----EGQKLMQEREVPEYLHHVNKRLEEEADRLITYLDQTTQKSL 440

  Fly   251 LAMPEIE-NGTQFKAILKRYLAARLQETRLSGKDYIQAFLGLCRGPLQRAL-------------- 300
            :|..|.: .|....|||::.|...|.|.|:.....:.......||.:|..|
Human   441 IATVEKQLLGEHLTAILQKGLNNLLDENRIQDLSLLYQLFSRVRGGVQVLLQQWIEYIKAFGSTI 505

  Fly   301 -----RDHTKLAEVVD---------AVC--KEE-------------INRKGQIIDPTRLLVTYAN 336
                 :|.|.:.|::|         .:|  |.|             ||::..  .|..|:..|.:
Human   506 VINPEKDKTMVQELLDFKDKVDHIIDICFLKNEKFINAMKEAFETFINKRPN--KPAELIAKYVD 568

  Fly   337 ELMTKRQESEEAIIDELKRIVKCV----EFLSDEYKFIDMYLKALRIRQINETSTSDGVESIMYS 397
            ..:  |..::||..:||::::..:    .|:..:..|...|.|.|..|.:...|.|...|..|.|
Human   569 SKL--RAGNKEATDEELEKMLDKIMIIFRFIYGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLS 631

  Fly   398 LLNKKMANFVTRCIYVQLRDVDKLRTLKKEFQDHLNSKGIK---------LGFDFRPKCFKNDGS 453
            .|..:.....|..:....:|::..:.:..:|:.::.::.:.         |...:.|       :
Human   632 KLKHECGAAFTSKLEGMFKDMELSKDIMIQFKQYMQNQNVPGNIELTVNILTMGYWP-------T 689

  Fly   454 FENFNLTLPDELQQAWKEFRIFY----EARKLQSKAII---QLNNELSSGEITCHLNQSVYILEV 511
            :....:.||.|:.:..:.|:.||    ..||||.::.:   .|..|...|:..         |:|
Human   690 YVPMEVHLPPEMVKLQEIFKTFYLGKHSGRKLQWQSTLGHCVLKAEFKEGKKE---------LQV 745

  Fly   512 STLQMAVLMLFNRHERFTEQELVTALGVELETLQEALKQI---KFLVYIEVNKVNYIE------I 567
            |..|..||::||..|.|:.:|:..|.|:|...|:..|:.:   |..|..:..|...||      .
Human   746 SLFQTLVLLMFNEGEEFSLEEIKQATGIEDGELRRTLQSLACGKARVLAKNPKGKDIEDGDKFIC 810

  Fly   568 NMDFTNRKRRLFCNEPLPRKMRK-IEEKSEIELKIRRDK--QVDAAIVRIMKGQKQLEYSELISL 629
            |.||.::..|:..|:   .:|:: :||::....::.:|:  |:|||||||||.:|.|.::.|:|.
Human   811 NDDFKHKLFRIKINQ---IQMKETVEEQASTTERVFQDRQYQIDAAIVRIMKMRKTLSHNLLVSE 872

  Fly   630 VYEELKDRVKPQVSFIKKRLDYLVEREYLERD----NYYN 665
            ||.:||..|||  :.:|||::.|::|:|:|||    |.||
Human   873 VYNQLKFPVKP--ADLKKRIESLIDRDYMERDKENPNQYN 910

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cul6	NP_648620.1	COG5647	25..670	CDD:227934	169/755 (22%)
CUL4B	NP_003579.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..100
		Nuclear localization signal. /evidence=ECO:0000269|PubMed:19801544	55..58
		Cullin	217..814	CDD:459983	126/645 (20%)
		Cullin_Nedd8	842..907	CDD:214883	31/66 (47%)