DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cul6 and CUL4B

DIOPT Version :9

Sequence 1:	NP_648620.1	Gene:	Cul6 / 39474	FlyBaseID:	FBgn0036332	Length:	670	Species:	Drosophila melanogaster
Sequence 2:	NP_003579.3	Gene:	CUL4B / 8450	HGNCID:	2555	Length:	913	Species:	Homo sapiens

Alignment Length:	755	Identity:	169/755 - (22%)
Similarity:	307/755 - (40%)	Gaps:	173/755 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 DDYTSFDGQKLMHLYHLIYKQCAAERNWNNPAQKNGRSLYIVLSDCLMKRLKNI------AWVME 88
            ::||....|||......|....:.:.|.....|.........:|..|.|:|:.|      |.:.:
Human   210 ENYTDETWQKLKEAVEAIQNSTSIKYNLEELYQAVENLCSYKISANLYKQLRQICEDHIKAQIHQ 274

  Fly    89 NQLDDNKPIRLIAKYLEHWVPYQRSCEKLNLACYHFNRNWVERERLKGDKETYP--------IYR 145
            .:.|....:..:.|....|..:.|....:.......:|.:|.:..:      .|        ::|
Human   275 FREDSLDSVLFLKKIDRCWQNHCRQMIMIRSIFLFLDRTYVLQNSM------LPSIWDMGLELFR 333

  Fly   146 LAMISWKELVFEPSVTILAAIRLILSQMPREYN-----KSLEYQVYQVLQSIVELYAN-DKYQDV 204
            ..:||.:::   .:.||...:.||    .||.|     :||       |:|::.:.:: ..|||
Human   334 AHIISDQKV---QNKTIDGILLLI----ERERNGEAIDRSL-------LRSLLSMLSDLQIYQD- 383

  Fly   205 SLPSRIDKIFTEKVMDFYKSTTLHEFQKIVVSNDYKDFKHFL-------------------RYAC 250
                ..::.|.|:....|.:    |.||::...:..::.|.:                   :.:.
Human   384 ----SFEQRFLEETNRLYAA----EGQKLMQEREVPEYLHHVNKRLEEEADRLITYLDQTTQKSL 440

  Fly   251 LAMPEIE-NGTQFKAILKRYLAARLQETRLSGKDYIQAFLGLCRGPLQRAL-------------- 300
            :|..|.: .|....|||::.|...|.|.|:.....:.......||.:|..|
Human   441 IATVEKQLLGEHLTAILQKGLNNLLDENRIQDLSLLYQLFSRVRGGVQVLLQQWIEYIKAFGSTI 505

  Fly   301 -----RDHTKLAEVVD---------AVC--KEE-------------INRKGQIIDPTRLLVTYAN 336
                 :|.|.:.|::|         .:|  |.|             ||::..  .|..|:..|.:
Human   506 VINPEKDKTMVQELLDFKDKVDHIIDICFLKNEKFINAMKEAFETFINKRPN--KPAELIAKYVD 568

  Fly   337 ELMTKRQESEEAIIDELKRIVKCV----EFLSDEYKFIDMYLKALRIRQINETSTSDGVESIMYS 397
            ..:  |..::||..:||::::..:    .|:..:..|...|.|.|..|.:...|.|...|..|.|
Human   569 SKL--RAGNKEATDEELEKMLDKIMIIFRFIYGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLS 631

  Fly   398 LLNKKMANFVTRCIYVQLRDVDKLRTLKKEFQDHLNSKGIK---------LGFDFRPKCFKNDGS 453
            .|..:.....|..:....:|::..:.:..:|:.::.::.:.         |...:.|       :
Human   632 KLKHECGAAFTSKLEGMFKDMELSKDIMIQFKQYMQNQNVPGNIELTVNILTMGYWP-------T 689

  Fly   454 FENFNLTLPDELQQAWKEFRIFY----EARKLQSKAII---QLNNELSSGEITCHLNQSVYILEV 511
            :....:.||.|:.:..:.|:.||    ..||||.::.:   .|..|...|:..         |:|
Human   690 YVPMEVHLPPEMVKLQEIFKTFYLGKHSGRKLQWQSTLGHCVLKAEFKEGKKE---------LQV 745

  Fly   512 STLQMAVLMLFNRHERFTEQELVTALGVELETLQEALKQI---KFLVYIEVNKVNYIE------I 567
            |..|..||::||..|.|:.:|:..|.|:|...|:..|:.:   |..|..:..|...||      .
Human   746 SLFQTLVLLMFNEGEEFSLEEIKQATGIEDGELRRTLQSLACGKARVLAKNPKGKDIEDGDKFIC 810

  Fly   568 NMDFTNRKRRLFCNEPLPRKMRK-IEEKSEIELKIRRDK--QVDAAIVRIMKGQKQLEYSELISL 629
            |.||.::..|:..|:   .:|:: :||::....::.:|:  |:|||||||||.:|.|.::.|:|.
Human   811 NDDFKHKLFRIKINQ---IQMKETVEEQASTTERVFQDRQYQIDAAIVRIMKMRKTLSHNLLVSE 872

  Fly   630 VYEELKDRVKPQVSFIKKRLDYLVEREYLERD----NYYN 665
            ||.:||..|||  :.:|||::.|::|:|:|||    |.||
Human   873 VYNQLKFPVKP--ADLKKRIESLIDRDYMERDKENPNQYN 910

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cul6	NP_648620.1	COG5647	25..670	CDD:227934	169/755 (22%)
		CULLIN	362..500	CDD:214545	30/153 (20%)
		Cullin_Nedd8	606..661	CDD:287520	28/54 (52%)
CUL4B	NP_003579.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..100
		Nuclear localization signal. /evidence=ECO:0000269\|PubMed:19801544	55..58
		Cullin	218..813	CDD:279260	126/643 (20%)
		CULLIN	596..736	CDD:214545	28/146 (19%)
		Cullin_Nedd8	842..907	CDD:214883	31/66 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1040292at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920